Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kathryn M. Rubey"'
Autor:
Kathryn M. Rubey, Alexander R. Mukhitov, Jia Nong, Jichuan Wu, Vera P. Krymskaya, Jacob W. Myerson, G. Scott Worthen, Jacob S. Brenner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Despite the power of antibiotics, bacterial infections remain a major killer, due to antibiotic resistance and hosts with dysregulated immune systems. We and others have been developing drug-loaded nanoparticles that home to the sites of infection an
Externí odkaz:
https://doaj.org/article/e813c9186b2f4af98701330fc592cef8
Autor:
G. Scott Worthen, Ning Dai, Andrew J. Paris, Lynn A. Spruce, Steven H. Seeholzer, Joseph H. Oved, Ping Wang, Mortimer Poncz, Kandace Gollomp, Kathryn M Rubey
Publikováno v:
Blood. 137:392-397
Neutrophils are critical mediators of host defense in pathogen-induced and sterile inflammation. Excessive neutrophil activation has been associated with increased host pathology through collateral organ damage. The beneficial aspects of neutrophil a
Autor:
Char Witmer, Ashley D Osborne, Christopher S. Thom, Kathryn M. Rubey, Stacey Kleinman, Leah H. Carr, Danielle Callaway, Emily Echevarria, Michele P. Lambert, Elizabeth Salazar, Thomas Pawlowski, John Flibotte, Matthew Devine
Publikováno v:
J Thromb Haemost
BACKGROUND: Extreme thrombocytosis (EXT, platelet count >1000 × 10(3)/μl) is an uncommon but potentially clinically significant finding. Primary EXT in the setting of myeloproliferative disorders is linked to thrombotic and/or bleeding complication
Autor:
Zhicheng Wang, Elizabeth D. Hood, Jia Nong, Jing Ding, Oscar A. Marcos‐Contreras, Patrick M. Glassman, Kathryn M. Rubey, Michael Zaleski, Carolann L. Espy, Damodara Gullipali, Takashi Miwa, Vladimir R. Muzykantov, Wen‐Chao Song, Jacob W. Myerson, Jacob S. Brenner
Publikováno v:
Adv Mater
Complement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by the complement protein C3, leading to clearance by phagocytes, fouling of targeting moieties, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b52162b5f2fbd1c3dfc147f63d1dae7
https://europepmc.org/articles/PMC9062787/
https://europepmc.org/articles/PMC9062787/
Autor:
Vincent M. Rotello, Laura T. Ferguson, Tea Shuvaeva, Nahal Habibi, Colin F. Greineder, David C. Luther, George S Worthen, Priyal Patel, Landis R. Walsh, Jacob W. Myerson, Oscar A. Marcos-Contreras, Jia Nong, Jichuan Wu, Hong-Ying Zhang, Liudmila L. Mazaleuskaya, Marco E Zamora, Joerg Lahann, Ian Johnston, Michael H Zaleski, Jason V. Gregory, Vladimir R. Muzykantov, Raisa Yu Kiseleva, Elizabeth D. Hood, Kathryn M Rubey, Samir Mitragotri, Jacob S. Brenner, Tilo Grosser, Yi-Wei Lee, Patrick M. Glassman
This study shows that the supramolecular arrangement of proteins in nanoparticle structures predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We observed homing to inflamed lungs for a variety of nanoparticles with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de3c7e5e03827014748aaac9cf92e29
https://pub.uni-bielefeld.de/record/2965299
https://pub.uni-bielefeld.de/record/2965299
Autor:
Zhicheng Wang, Elizabeth D. Hood, Jia Nong, Jing Ding, Oscar A. Marcos‐Contreras, Patrick M. Glassman, Kathryn M. Rubey, Michael Zaleski, Carolann L. Espy, Damodara Gullipali, Takashi Miwa, Vladimir R. Muzykantov, Wen‐Chao Song, Jacob W. Myerson, Jacob S. Brenner
Publikováno v:
Advanced Materials. 34:2270059
Autor:
Christopher S. Thom, John Flibotte, Stacey Kleinman, Matthew Devine, Danielle Callaway, Michele P. Lambert, Thomas Pawlowski, Ashley D Osborne, Leah H. Carr, Emily Echevarria, Kathryn M. Rubey, Elizabeth Salazar
Extreme thrombocytosis (ET, platelet count >1000 × 103/ul) is an uncommon clinical finding 1. Primary ET is associated with myeloproliferative disorders, such as essential thrombocythemia 2. Secondary ET is more common and occurs in reaction to infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76dad94721fc94cf87ae39a8b0d2e77
https://doi.org/10.1101/2020.06.01.20119438
https://doi.org/10.1101/2020.06.01.20119438
Autor:
Michael H Zaleski, Landis R. Walsh, Ian Johnston, Yi-Wei Lee, Raisa Yu Kiseleva, Laura T. Ferguson, Nahal Habibi, David C. Luther, Kathryn M Rubey, Priyal Patel, Colin F. Greineder, Patrick M. Glassman, George S Worthen, Samir Mitragotri, Tea Shuvaeva, Jason V. Gregory, Jacob W. Myerson, Oscar A. Marcos-Contreras, Jia Nong, Vincent M. Rotello, Vladimir R. Muzykantov, Joerg Lahann, Marco E Zamora, Jacob S. Brenner, Elizabeth D. Hood
Acute lung inflammation has severe morbidity, as seen in COVID-19 patients. Lung inflammation is accompanied or led by massive accumulation of neutrophils in pulmonary capillaries (“margination”). We sought to identify nanostructural properties t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc962ac186718faf7a79ed5b27ef4f7
https://doi.org/10.1101/2020.04.15.037564
https://doi.org/10.1101/2020.04.15.037564
Autor:
Jacob S. Brenner, Kathryn M. Rubey
Publikováno v:
Adv Drug Deliv Rev
The ubiquity and potency of antibiotics may give the false impression that infection is a solved problem. Unfortunately, even bacterial infections, the target of antibiotics, remain a major cause of illness and death. Several major unmet needs persis