Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kathryn M. Pflug"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The prognosis of high-grade gliomas, such as glioblastoma multiforme (GBM), is extremely poor due to the highly invasive nature of these aggressive cancers. Previous work has demonstrated that TNF-weak like factor (TWEAK) induction of the no
Externí odkaz:
https://doaj.org/article/328459193936475a9bd7821b9e0a224e
Autor:
Michael L. Kamradt, Ji-Ung Jung, Kathryn M. Pflug, Dong W. Lee, Victor Fanniel, Raquel Sitcheran
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-18 (2021)
Abstract Cancers, including glioblastoma multiforme (GBM), undergo coordinated reprogramming of metabolic pathways that control glycolysis and oxidative phosphorylation (OXPHOS) to promote tumor growth in diverse tumor microenvironments. Adaptation t
Externí odkaz:
https://doaj.org/article/2f0bf402e3484a34827201f03d1b909a
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1869:166682
BackgroundNF-κB-inducing kinase (NIK) is a critical regulator of immunity and inflammation and NIK loss-of-function mutations have recently been described in patients with primary immunodeficiency disease. Based on our previous work showing that NIK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0809fa2728d877b62579742a869d7ac0
https://doi.org/10.1016/j.bbadis.2023.166682
https://doi.org/10.1016/j.bbadis.2023.166682
Publikováno v:
ChemMedChem. 14:1575-1579
We hypothesized that conjugation of the near-infrared dye MHI-148 with the anti-leukemia drug dasatinib might produce a potential theranostic for glioblastoma. In fact, the conjugate was found to bind the kinases Src and Lyn, and to inhibit the viabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab00a92638694d876782e720c48af33
https://doi.org/10.1002/cmdc.201900356
https://doi.org/10.1002/cmdc.201900356
Autor:
Victor Fanniel, Kathryn M. Pflug, Michael L. Kamradt, Dong W. Lee, Raquel Sitcheran, Ji-Ung Jung
Publikováno v:
Cell Death and Disease, Vol 12, Iss 3, Pp 1-18 (2021)
Cell Death & Disease
Cell Death & Disease
Cancers, including glioblastoma multiforme (GBM), undergo coordinated reprogramming of metabolic pathways that control glycolysis and oxidative phosphorylation (OXPHOS) to promote tumor growth in diverse tumor microenvironments. Adaptation to limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28f08d74858793e228f97c40108a717
https://doi.org/10.1038/s41419-020-03383-z
https://doi.org/10.1038/s41419-020-03383-z
Autor:
Raquel Sitcheran, Kathryn M. Pflug
Publikováno v:
International Journal of Molecular Sciences
NF-κB-inducing kinase (NIK), the essential upstream kinase, which regulates activation of the noncanonical NF-κB pathway, has important roles in regulating immunity and inflammation. In addition, NIK is vital for maintaining cellular health through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bdf45c1baa11c4bb95cdc4c883fa46
http://europepmc.org/articles/PMC7696043
http://europepmc.org/articles/PMC7696043
Autor:
Zhengyang Jiang, Syed Muhammad Usama, Raquel Sitcheran, Dacheng Kuai, Kevin Burgess, Kathryn M. Pflug, Xin Yan
A small subset of heptamethine dyes (cyanine-7 or Cy7) share an intriguing characteristic: preferential tumor accumulation and retention. These dyes absorb in the near-infrared (NIR) region (above 750 nm) and perform active targeting to deliver thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31eb1d0e6a27f3cfbb2a2633194be7ff
https://europepmc.org/articles/PMC7050787/
https://europepmc.org/articles/PMC7050787/
