Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kathryn M. Keefer"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The early stages of protein misfolding remain incompletely understood, as most mammalian proteinopathies are only detected after irreversible protein aggregates have formed. Cross-seeding, where one aggregated protein templates the misfoldin
Externí odkaz:
https://doaj.org/article/259adbae8b134b91a3ddc1e372d5a9a2
Autor:
Laura L. Arthur, Joyce J. Chung, Preetam Janakirama, Kathryn M. Keefer, Igor Kolotilin, Slavica Pavlovic-Djuranovic, Douglas L. Chalker, Vojislava Grbic, Rachel Green, Rima Menassa, Heather L. True, James B. Skeath, Sergej Djuranovic
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Hypomorphic mutations are a valuable tool for analysing gene function, but current methods have difficult to predict effects on gene expression and are organism specific. Here the authors present a pan-species approach using variable polyA tracks to
Externí odkaz:
https://doaj.org/article/d5276f10700a4a45bc605bc24297890b
Autor:
Laura L. Arthur, Joyce J. Chung, Preetam Janakirama, Kathryn M. Keefer, Igor Kolotilin, Slavica Pavlovic-Djuranovic, Douglas L. Chalker, Vojislava Grbic, Rachel Green, Rima Menassa, Heather L. True, James B. Skeath, Sergej Djuranovic
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 14112 (2017); Published: 20 January 2017; Updated: 16 February 2017 The original version of this Article contained a typographical error in the spelling of the Author Preetam Janakirama, which was incorrectly
Externí odkaz:
https://doaj.org/article/076955fbe85145baa924506b1f72c50e
Autor:
Kathryn M Keefer, Heather L True
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006431 (2016)
The nascent polypeptide-associated complex (NAC) is a highly conserved but poorly characterized triad of proteins that bind near the ribosome exit tunnel. The NAC is the first cotranslational factor to bind to polypeptides and assist with their prope
Externí odkaz:
https://doaj.org/article/8288656dcb9348cea452f83463d40cdd
Autor:
Heather L. True, Kathryn M. Keefer
Publikováno v:
Molecular Microbiology. 105:860-868
Summary Molecular chaperones are responsible for managing protein folding from translation through degradation. These crucial machines ensure that protein homeostasis is optimally maintained for cell health. However, ‘too much of a good thing’ ca
Autor:
Rima Menassa, Slavica Pavlovic-Djuranovic, Igor Kolotilin, James B. Skeath, Rachel Green, Preetam Jankirama, Kathryn M. Keefer, Vojislava Grbic, Heather L. True, Laura L. Arthur, Douglas L. Chalker, Sergej Djuranovic, Joyce J Chung
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Hypomorphic mutations are a valuable tool for both genetic analysis of gene function and for synthetic biology applications. However, current methods to generate hypomorphic mutations are limited to a specific organism, change gene expression unpredi
Autor:
Vojislava Grbic, Joyce J Chung, Rima Menassa, Heather L. True, Sergej Djuranovic, Slavica Pavlovic-Djuranovic, Kathryn M. Keefer, James B. Skeath, Rachel Green, Douglas L. Chalker, Igor Kolotilin, Preetam Janakirama, Laura L. Arthur
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 14112 (2017); Published: 20 January 2017; Updated: 16 February 2017 The original version of this Article contained a typographical error in the spelling of the Author Preetam Janakirama, which was incorrectly
Autor:
Heather L. True, Kathryn M. Keefer
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006431 (2016)
PLoS Genetics
PLoS Genetics
The nascent polypeptide-associated complex (NAC) is a highly conserved but poorly characterized triad of proteins that bind near the ribosome exit tunnel. The NAC is the first cotranslational factor to bind to polypeptides and assist with their prope