Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Kathryn M. Hart"'
Autor:
Maxwell I. Zimmerman, Kathryn M. Hart, Carrie A. Sibbald, Thomas E. Frederick, John R. Jimah, Catherine R. Knoverek, Niraj H. Tolia, Gregory R. Bowman
Publikováno v:
ACS Central Science, Vol 3, Iss 12, Pp 1311-1321 (2017)
Externí odkaz:
https://doaj.org/article/74ea6caeaaeb48979b0f3c73141052a4
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM su
Externí odkaz:
https://doaj.org/article/234708999b6a401a85bad9993edf6cfe
Autor:
Sonya Lee, Cynthia N. Okoye, Devin Biesbrock, Emily C. Harris, Katelyn F. Miyasaki, Ryan G. Rilinger, Megalan Tso, Kathryn M. Hart
Publikováno v:
Biochemistry. 61(5)
Thermodynamic stability represents one important constraint on protein evolution, but the molecular basis for how mutations that change stability impact fitness remains unclear. Here, we demonstrate that a prevalent global suppressor mutation in TEM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da18d63da605afadd23c6d57fc05c18f
https://pubmed.ncbi.nlm.nih.gov/35142509
https://pubmed.ncbi.nlm.nih.gov/35142509
Autor:
Kathryn M Hart, Katelyn E Moeder, Chris M W Ho, Maxwell I Zimmerman, Thomas E Frederick, Gregory R Bowman
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178678 (2017)
Allosteric drugs, which bind to proteins in regions other than their main ligand-binding or active sites, make it possible to target proteins considered "undruggable" and to develop new therapies that circumvent existing resistance. Despite growing i
Externí odkaz:
https://doaj.org/article/2e2ae9d93da7443fa8dfefba3b8eff92
Publikováno v:
American family physician. 104(3)
Home blood pressure monitoring provides important diagnostic information beyond in-office blood pressure readings and offers similar results to ambulatory blood pressure monitoring. Home blood pressure monitoring involves patients independently measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::630b3b6a3573be781502ba96d974f112
https://pubmed.ncbi.nlm.nih.gov/35166495
https://pubmed.ncbi.nlm.nih.gov/35166495
Autor:
Michael J. Greenberg, Kathryn M. Hart, Justin R. Porter, Carrie A. Sibbald, Katelyn E. Moeder, Maxwell I. Zimmerman, Gregory R. Bowman
Publikováno v:
Biophysical Journal. 116:818-830
Proteins are dynamic molecules that undergo conformational changes to a broad spectrum of different excited states. Unfortunately, the small populations of these states make it difficult to determine their structures or functional implications. Compu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af54a9195ca4506e7e429bf9709ec72
https://doi.org/10.1016/j.bpj.2018.11.3144
https://doi.org/10.1016/j.bpj.2018.11.3144
Autor:
Kathryn M. Hart
Publikováno v:
Journal of the American Board of Family Medicine : JABFM. 33(5)
The JABFM policy brief by Wilkensen et al[1][1] highlights gender differences in work hours between male and female family physicians, with men reporting significantly more hours of total and direct patient care across age groups. This comes as no su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b047555e0d50953a7e88eb76719d4f7
https://pubmed.ncbi.nlm.nih.gov/32989059
https://pubmed.ncbi.nlm.nih.gov/32989059
Autor:
Catherine R. Knoverek, John R. Jimah, Carrie A. Sibbald, Niraj H. Tolia, Thomas E. Frederick, Maxwell I. Zimmerman, Gregory R. Bowman, Kathryn M. Hart
Publikováno v:
ACS Central Science
ACS Central Science, Vol 3, Iss 12, Pp 1311-1321 (2017)
ACS Central Science, Vol 3, Iss 12, Pp 1311-1321 (2017)
Protein stabilization is fundamental to enzyme function and evolution, yet understanding the determinants of a protein’s stability remains a challenge. This is largely due to a shortage of atomically detailed models for the ensemble of relevant pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01a762bdf4ce5dc97b6cc1090603f1c
https://doi.org/10.1021/acscentsci.7b00465
https://doi.org/10.1021/acscentsci.7b00465
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 46
Proper folding of proteins is critical to producing the biological machinery essential for cellular function. The rates and energetics of a protein's folding process, which is described by its energy landscape, are encoded in the amino acid sequence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facf164a013b0ff4763875605682b1f6
https://doi.org/10.1073/pnas.1611781113
https://doi.org/10.1073/pnas.1611781113
Publikováno v:
MedChemComm. 7:118-127
Tabtoxinine-β-lactam (TβL) is a phytotoxin produced by plant pathogenic strains of Pseudomonas syringae. Unlike the majority of β-lactam antibiotics, TβL does not inhibit transpeptidase enzymes but instead is a potent, time-dependent inactivator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20c829e0b6b9aa93b1467745d41ef060
https://doi.org/10.1039/c5md00325c
https://doi.org/10.1039/c5md00325c