Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Kathryn M. Gauthier"'
Publikováno v:
PeerJ, Vol 2, p e414 (2014)
Background and Purpose. In rat middle cerebral arteries, endothelium-dependent hyperpolarization (EDH) is mediated by activation of calcium-activated potassium (KCa) channels specifically KCa2.3 and KCa3.1. Lipoxygenase (LOX) products function as end
Externí odkaz:
https://doaj.org/article/de53651cdc68441eb596524cb76c65f3
Publikováno v:
Endocrinology. 159:217-226
Angiotensin II (Ang II) and adrenocorticotropic hormone (ACTH) regulate adrenal vascular tone in vitro through endothelial and zona glomerulosa cell–derived mediators. The role of these mediators in regulating adrenal blood flow (ABF) and mean arte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8e446f4ca241e7af95a910228e526b
https://doi.org/10.1210/en.2016-1594
https://doi.org/10.1210/en.2016-1594
Autor:
Kathryn M. Gauthier, Daniel Goldman, Lawan Siangjong, John R. Falck, Ganesh Kumar, Narender Puli, William B. Campbell, Tamas Kriska, Emer M. Smyth
Publikováno v:
Acta Physiologica. 219:188-201
Aim 12/15-lipoxygenase (12/15-LO) metabolizes arachidonic acid (AA) into several vasoactive eicosanoids. In mouse arteries, we previously characterized the enzyme's 15-LO metabolites 12(S)-hydroxyeicosatetraenoic acid (HETE), 15-HETE, hydroxyepoxyeic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b715be442dfbab7df7daf71a6746a72
https://doi.org/10.1111/apha.12642
https://doi.org/10.1111/apha.12642
Autor:
Sang-Kyu Park, Benjamin A Falck, Kathryn M. Gauthier, Anja Herrnreiter, John R. Falck, William B. Campbell, Sandra L. Pfister
Publikováno v:
The Journal of biological chemistry. 293(27)
Endothelium-derived epoxyeicosatrienoic acids (EETs) have numerous vascular activities mediated by G protein–coupled receptors. Long-chain free fatty acids and EETs activate GPR40, prompting us to investigate the role of GPR40 in some vascular EET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27dd22e5b000d18286392f1cbf9d5d2
https://pubmed.ncbi.nlm.nih.gov/29777058
https://pubmed.ncbi.nlm.nih.gov/29777058
Autor:
Tengis S. Pavlov, William B. Campbell, Alexander Staruschenko, Sarah V Christain, Abdul H. Khan, Kathryn M. Gauthier, J. Capdevila, Jan Neckář, John D. Imig, John R. Falck
Publikováno v:
Clinical Science. 127:463-474
Epoxyeicosatrienoic acids (EETs) contribute to haemodynamics, electrolyte homoeostasis and blood pressure regulation, leading to the concept that EETs can be therapeutically targeted for hypertension. In the present study, multiple structural EET ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4640b3d7a6e70655b4ed77f130096c40
https://doi.org/10.1042/cs20130479
https://doi.org/10.1042/cs20130479
Autor:
Cody Cepura, Tamas Kriska, Tina C. Wan, A. Shaish, John A. Auchampach, Lawan Siangjong, John R. Falck, Kathryn M. Gauthier, William B. Campbell, Ganesh Kumar, Dror Haratz
Publikováno v:
Prostaglandins & Other Lipid Mediators. 106:8-15
Lipoxygenases regulate vascular function by metabolizing arachidonic acid (AA) to dilator eicosanoids. Previously, we showed that endothelium-targeted adenoviral vector-mediated gene transfer of the human 15-lipoxygenase-1 (h15-LO-1) enhances arteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f7417ae7d142b8dc22e005f1f9d20b
https://doi.org/10.1016/j.prostaglandins.2013.07.002
https://doi.org/10.1016/j.prostaglandins.2013.07.002
Publikováno v:
bchm. 394:1205-1212
Bradykinin causes vascular relaxations through release of endothelial relaxing factors including prostacyclin, nitric oxide (NO) and epoxyeicosatrienoic acids (EETs). Bradykinin is metabolized by angiotensin converting enzyme (ACE) and ACE inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4c5f7fd5f2d6e287f450cbbf4f5c06
https://doi.org/10.1515/hsz-2012-0348
https://doi.org/10.1515/hsz-2012-0348
Publikováno v:
Journal of Cardiovascular Pharmacology. 61:176-187
Endothelium-derived hyperpolarizing factors (EDHFs) regulate vascular tone by contributing to the vasorelaxations to shear stress and endothelial agonists such as bradykinin and acetylcholine. 15(S)-Hydroxy-11,12-epoxyeicosatrienoic acid (15-H-11,12-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae4a1d08cffc7864b0a1e47d4cd1297
https://doi.org/10.1097/fjc.0b013e31828165db
https://doi.org/10.1097/fjc.0b013e31828165db
Publikováno v:
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 17(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ff0c99c3ae7484db6c5bff1b382895
https://pubmed.ncbi.nlm.nih.gov/27202619
https://pubmed.ncbi.nlm.nih.gov/27202619
Publikováno v:
Hypertension. 57:323-329
Elevated concentrations of aldosterone are associated with several cardiovascular diseases. Angiotensin II increases aldosterone secretion and adrenal blood flow. This concurrent increase in steroidogenesis and adrenal blood flow is not understood. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63dcb6c67d4a2b57bcf61c831066b9c8
https://doi.org/10.1161/hypertensionaha.110.158311
https://doi.org/10.1161/hypertensionaha.110.158311