Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Kathryn M Thrailkill"'
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
In recent years, new therapies for the treatment of rare pediatric bone disorders have emerged, guided by an increasing understanding of the genetic and molecular etiology of these diseases. Herein, we review three such disorders, impacted by debilit
Externí odkaz:
https://doaj.org/article/43fad873255748e6bba285b6e9ad0605
Publikováno v:
Current opinion in endocrinology, diabetes, and obesity. 29(4)
In this review, we describe the three primary mouse models of insulin-deficiency diabetes that have been used to study the effects of type 1 diabetes (T1D) on skeletal outcomes. These models include streptozotocin (chemically)-induced diabetes, autoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b1380386c742246b9249a7c258e436
https://pubmed.ncbi.nlm.nih.gov/35749285
https://pubmed.ncbi.nlm.nih.gov/35749285
Autor:
Jeffry S. Nyman, Evangelia Kalaitzoglou, R. Clay Bunn, Sasidhar Uppuganti, Kathryn M. Thrailkill, John L. Fowlkes
Publikováno v:
Bone Reports, Vol 7, Iss C, Pp 1-8 (2017)
Those with type 1 diabetes (T1D) are more likely to suffer a fracture than age- and sex-matched individuals without diabetes, despite daily insulin therapy. In rodent studies examining the effect of bone- or glucose-targeting therapies on preventing
Externí odkaz:
https://doaj.org/article/919dfc139d4e4b9facd07bc85576a0cf
Autor:
John L. Fowlkes, Jeffry S. Nyman, R. Clay Bunn, Gael E. Cockrell, Elizabeth C. Wahl, Mallikarjuna R. Rettiganti, Charles K. Lumpkin Jr., Kathryn M. Thrailkill
Publikováno v:
Bone Reports, Vol 1, Iss C, Pp 16-19 (2015)
In type 1 diabetes, diabetic bone disease (DBD) is characterized by decreased bone mineral density, a state of low bone turnover and an increased risk of fracture. Animal models of DBD demonstrate that acquired alterations in trabecular and cortical
Externí odkaz:
https://doaj.org/article/89a6b74e20f0427e9bcf2ebdc2dff0b3
Autor:
Corey B. Hughes, George M. Mussman, Kathryn M. Thrailkill, Phil Ray, Virgilius Cornea, Robert C. Bunn, Iuliana Popescu, John L. Fowlkes
Publikováno v:
Cell and Tissue Research. 384:527-543
Inhibitors of sodium/glucose co-transporter 2 (SGLT2) are currently in clinical use for type 2 diabetes (T2D) treatment due to their anti-hyperglycemic effect exerted by the inhibition of glucose reabsorption in the kidney. Inhibition of SGLT2 is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c072ffe2c3a25971e234c3a1a212485d
https://doi.org/10.1007/s00441-020-03358-8
https://doi.org/10.1007/s00441-020-03358-8
Autor:
Evangelia Kalaitzoglou, Phil Ray, R. Clay Bunn, Kathryn M. Thrailkill, Iuliana Popescu, John L. Fowlkes
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports
Scientific Reports
The relationship between osteoblast-specific insulin signaling, osteocalcin activation and gluco-metabolic homeostasis has proven to be complex and potentially inconsistent across animal-model systems and in humans. Moreover, the impact of postnatall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f798d38f20bbb033671ee76b7e5568a0
http://link.springer.com/article/10.1038/s41598-020-65717-3
http://link.springer.com/article/10.1038/s41598-020-65717-3
Autor:
Sarah McDonald, Phil Ray, Robert C. Bunn, John L. Fowlkes, Kathryn M. Thrailkill, Iuliana Popescu
Publikováno v:
Acta histochemica. 124(7)
A primary underlying defect makes β-cells "susceptible" to no longer compensate for the peripheral insulin resistance and to trigger the onset of type 2 diabetes (T2D). New evidence suggests that in T2D, β-cells are not destroyed but experience a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ed562d71d6166d55246a313da60aa1
https://pubmed.ncbi.nlm.nih.gov/35969910
https://pubmed.ncbi.nlm.nih.gov/35969910
Publikováno v:
Bone
The RASopathies comprise an ever-growing number of clinical syndromes resulting from germline mutations in components of the RAS/MAPK signaling pathway. While multiple organs and tissues may be affected by these mutations, this review will focus on h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fa92cfe17d4254b78c987ad7f00024
https://doi.org/10.1016/j.bone.2021.116060
https://doi.org/10.1016/j.bone.2021.116060
Autor:
R. Clay Bunn, Kathryn M. Thrailkill, John L. Fowlkes, Sasidhar Uppuganti, Evangelia Kalaitzoglou, Jeffry S. Nyman
Publikováno v:
Bone Reports
Bone Reports, Vol 7, Iss C, Pp 1-8 (2017)
Bone Reports, Vol 7, Iss C, Pp 1-8 (2017)
Those with type 1 diabetes (T1D) are more likely to suffer a fracture than age- and sex-matched individuals without diabetes, despite daily insulin therapy. In rodent studies examining the effect of bone- or glucose-targeting therapies on preventing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c4cda6c2325cb5ecf74b85661e8219
http://europepmc.org/articles/PMC5508511
http://europepmc.org/articles/PMC5508511
Autor:
Kathryn M. Thrailkill, Sasidhar Uppuganti, John L. Fowlkes, Jacquelyn S. Pennings, Kate Garrett, Jeffry S. Nyman, Iuliana Popescu, Philip D. Ray, R. Clay Bunn
Publikováno v:
Bone
Selective sodium-dependent glucose co-transporter 2 inhibitors (SGLT2Is) are oral hypoglycemic medications utilized increasingly in the medical management of hyperglycemia among persons with type 2 diabetes (T2D). Despite favorable effects on cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6448f26cb215c87ea6840ab38640c54
https://europepmc.org/articles/PMC7059549/
https://europepmc.org/articles/PMC7059549/
