Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Kathryn M Monroe"'
Autor:
Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti‐Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun‐Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haass
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 4, Pp 1-22 (2020)
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) is essential for the transition of homeostatic microglia to a disease‐associated microglial state. To enhance TREM2 activity, we sought to selectively increase the full‐length prot
Externí odkaz:
https://doaj.org/article/a1d63c8ac22b4f22bf081e18a44b1145
Autor:
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I. Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E. Pizzo, Rachel Prorok, Elliot Thomsen, Laura M. Bartos, Philipp Beumers, Anja Capell, Sonnet S. Davis, Lis de Weerd, Jason C. Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T. Kunte, Lea H. Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O. Torres, Hoang N. Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H. Suh, Robert G. Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y. Joy Yu Zuchero, Dolo Diaz, Mark S. Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J. Watts, Christian Haass, Joseph W. Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E. Sanchez, Kathryn M. Monroe
Publikováno v:
Nature neuroscience 26, 416-429 (2023). doi:10.1038/s41593-022-01240-0
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor may be a useful therapeutic strategy. Here we describe a high-affinity human TREM2-activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a1a80e71ec71d0d797c20ae600bdaa
https://doi.org/10.1038/s41593-022-01240-0
https://doi.org/10.1038/s41593-022-01240-0
Autor:
Nicole L.K. Galloway, Gilad Doitsh, Kathryn M. Monroe, Zhiyuan Yang, Isa Muñoz-Arias, David N. Levy, Warner C. Greene
Publikováno v:
Cell Reports, Vol 12, Iss 10, Pp 1555-1563 (2015)
The progressive depletion of CD4 T cells underlies clinical progression to AIDS in untreated HIV-infected subjects. Most dying CD4 T cells correspond to resting nonpermissive cells residing in lymphoid tissues. Death is due to an innate immune respon
Externí odkaz:
https://doaj.org/article/83ab6fe338854f03acbeae99c079790c
Autor:
Marco Prinz, Gilbert Di Paolo, Kathryn M. Monroe, Alkmini Damkou, Christian Haass, Lenka Vaculčiaková, Ioannis Alexopoulos, Martina Schifferer, Joseph W. Lewcock, Dieter Lütjohann, Christian Klose, Takahiro Masuda, Ludovico Cantuti-Castelvetri, Mar Bosch-Queralt, Kai Schlepckow, Mikael Simons
Publikováno v:
Nature Metabolism
Nature metabolism 3(2), 211-227 (2021). doi:10.1038/s42255-021-00341-7
Nat Metab
Nature metabolism 3(2), 211-227 (2021). doi:10.1038/s42255-021-00341-7
Nat Metab
Proregenerative responses are required for the restoration of nervous-system functionality in demyelinating diseases such as multiple sclerosis (MS). Yet, the limiting factors responsible for poor CNS repair are only partially understood. Here, we te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a481828eb5d9cbb4b8b786c5a8efda4
https://doi.org/10.1038/s42255-021-00341-7
https://doi.org/10.1038/s42255-021-00341-7
Autor:
Elie J. Diner, Dara L. Burdette, Stephen C. Wilson, Kathryn M. Monroe, Colleen A. Kellenberger, Mamoru Hyodo, Yoshihiro Hayakawa, Ming C. Hammond, Russell E. Vance
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1355-1361 (2013)
The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic DNA was proposed to induce the synthesis of cyclic GMP-AMP (cGAMP) upon binding to an enzyme called cGAMP synthase (cGAS
Externí odkaz:
https://doaj.org/article/2a539847a7d542709f20c5ca08f20165
Autor:
Benjamin J. Andreone, Ju Shi, Bettina Van Lengerich, Thomas Sandmann, Sonnet S. Davis, Anil Rana, Yuan Mei, Giuseppe Astarita, Joseph W. Lewcock, Karin Lin, Ceyda Llapashtica, Kathryn M. Monroe, Gilbert Di Paolo, Laralynne Przybyla
Publikováno v:
Nature Neuroscience. 23:927-938
Human genetic data indicate that microglial dysfunction contributes to the pathology of Alzheimer's disease (AD), exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2 (TREM2) and, more recently, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb145906d4543ac62c339523d997557
https://doi.org/10.1038/s41593-020-0650-6
https://doi.org/10.1038/s41593-020-0650-6
Autor:
Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl‐Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haass
Publikováno v:
The EMBO journal 41(4), e109108 (2022). doi:10.15252/embj.2021109108
Haploinsufficiency of the progranulin (PGRN)-encoding gene (GRN) causes frontotemporal lobar degeneration (GRN-FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, and TDP-43 deposition. To understand the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561d67316e9f278a34f08b959e8dd608
https://pub.dzne.de/record/163471
https://pub.dzne.de/record/163471
Autor:
Mar Bosch-Queralt, Ludovico Cantuti-Castelvetri, Alkmini Damkou, Martina Schifferer, Kai Schlepckow, Ioannis Alexopoulos, Dieter Lütjohann, Christian Klose, Lenka Vaculčiaková, Takahiro Masuda, Marco Prinz, Kathryn M. Monroe, Gilbert Di Paolo, Joseph W. Lewcock, Christian Haass, Mikael Simons
Publikováno v:
Nature metabolism 5(3), 531 (2023). doi:10.1038/s42255-023-00750-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec15c84c89d764a8a3c0c559c449d50
https://doi.org/10.1038/s42255-023-00750-w
https://doi.org/10.1038/s42255-023-00750-w
Autor:
Ryan J. Watts, Kathryn M. Monroe, Junhua Wang, Melina Lenser, Jennifer Hsiao-Nakamoto, Hoang Nguyen, Todd P. Logan, Do Jin Kim, Fen Huang, Ritesh Ravi, Gilbert Di Paolo, Anil Rana, Kannan Gunasekaran, Yaneth Robles-Colmenares, Gerald M. Cherf, Buyankhishig Tsogtbaatar, Ceyda Llapashtica, Kirk R. Henne, Hilda Solanoy, Pascal E. Sanchez, Yashas Rajendra, Mihalis Kariolis, Ray Lieh Yoon Low, Roni Chau, Laralynne Przybyla, Michelle E. Pizzo, Chi-Lu Chiu, Meng Fang, Anastasia G. Henry, Giuseppe Astarita, Mark S. Dennis, Adam L. Boxer, Sarah L. DeVos, Sonnet S. Davis, Hilary W. Heuer, René Meisner, Joseph W. Lewcock, Devendra B. Srivastava, Bradley F. Boeve, Meredith E. K. Calvert, Katrina W. Lexa, Rachel Prorok, Lukas L. Skuja, Dolores Diaz, Akhil Bhalla, Matthew Simon, Jung H. Suh, Ankita Srivastava, Timothy K. Earr, Howard J. Rosen, Joseph Duque, Bettina Van Lengerich, Elizabeth W. Sun
Publikováno v:
Cell
Cell, vol 184, iss 18
Cell, vol 184, iss 18
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we found that Grn(−/−) mice exhibit a global deficiency in bis(monoacylglycero)phosphate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e8760616b55660b5a69ea73b7ad6da
https://europepmc.org/articles/PMC8489356/
https://europepmc.org/articles/PMC8489356/
Autor:
Kathryn M, Monroe, Gilbert, Di Paolo
Publikováno v:
Nature neuroscience. 24(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d84f66e4650da762945954dcd0a4bd7f
https://pubmed.ncbi.nlm.nih.gov/33603230
https://pubmed.ncbi.nlm.nih.gov/33603230