Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kathryn M Jensen"'
Autor:
Eugene V. Millar, Kathryn M Jensen, Robert Weatherholtz, Katherine L. O'Brien, Hasan S. Jafri, Mathuram Santosham, Ruth A. Karron, Terramika Bellamy, Brian Harris, Genevieve A. Losonsky, Aruna Chandran, Lawrence H. Moulton, Raymond Reid, M. Pamela Griffin
Publikováno v:
The Lancet Infectious Diseases. 15:1398-1408
Summary Background Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections in children. We aimed to assess the safety and efficacy of an anti-RSV monoclonal antibody (motavizumab) in healthy term (≥36 weeks'
Autor:
Xiang-Qing Yu, Gabriel Robbie, Howard I. Schwartz, Terramika Bellamy, Kathryn M Jensen, Martha Hernandez-Illas, Yuling Wu, Hasan S. Jafri, Mark T. Esser
Publikováno v:
Antimicrobial Agents and Chemotherapy
MEDI4893 is an investigational immunoglobulin G1(κ) monoclonal antibody that specifically binds to and neutralizes alpha-toxin, a key Staphylococcus aureus virulence factor. A triple-amino-acid substitution, M252Y/S254T/T256E, was engineered into th
Autor:
M. Pamela Griffin, Kathryn M Jensen, Genevieve A. Losonsky, Nita K. Patel, Ryan Criste, William Dall'acqua, Gabriel Robbie
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:6147-6153
The study objective was to evaluate the pharmacokinetics (PK), antidrug antibody (ADA), and safety of motavizumab-YTE (motavizumab with amino acid substitutions M252Y/S254T/T256E [YTE]), an Fc-modified anti-respiratory syncytial virus (RSV) monoclona
Autor:
Genevieve A. Losonsky, Eric A. F. Simões, Jay M. Lieberman, Jim Buttery, Ram Yogev, Evan J. Anderson, Penelope H. Dennehy, Joseph B. Domachowske, Kathryn M Jensen
Publikováno v:
Journal of the Pediatric Infectious Diseases Society. 1:212-222
Human metapneumovirus (HMPV) is a significant cause of respiratory tract infections. Little is known about HMPV in children who are at high risk for lower respiratory tract infection (LRTI).To determine the prevalence of HMPV in high-risk children an
Autor:
Joseph B. Domachowske, Kathryn M Jensen, Filip Dubovsky, Therese Takas, Anis Khan, M. Pamela Griffin, Tonya Villafana
Publikováno v:
Pediatrics. 141:256-256
Purpose: RSV is the most common cause of lower respiratory tract infection (LRTI) among infants. A significant unmet need exists for RSV prevention in healthy infants. Our goal is to develop a monoclonal antibody with an extended half-life (t½) to p
Autor:
Kathryn M Jensen, Hoyin Mok, Xiang-Qing Yu, Mark T. Esser, Lorin Roskos, Alexey Ruzin, David E. Tabor, Hasan S. Jafri, Li Yu, Christine Tkaczyk, Yuling Wu, Terramika Bellamy
Publikováno v:
Clinical & Translational Immunology
Objectives MEDI4893 is a novel, long‐acting human monoclonal antibody targeting Staphylococcus aureus (SA) alpha toxin (AT). This report presents the results of the exploratory analyses from a randomised phase 1 dose‐escalation study in healthy h
Publikováno v:
Electoral Studies. 26:727-734
In one of the most frequently cited articles published in Electoral Studies, Carey and Shugart [Cary, J.M., Shugart, M.S. 1995. Incentives to cultivate a personal vote: a rank ordering of electoral formulas. Electoral Studies 14(4), 417–439] hypoth
Autor:
Therese Takas, Gabriel Robbie, M. Pamela Griffin, Filip Dubovsky, Anis Khan, Kathryn M Jensen
Publikováno v:
Open Forum Infectious Diseases. 2
Autor:
Mark T. Esser, Therese Takas, Kathryn M Jensen, Joseph B. Domachowske, Filip Dubovsky, Anis Khan, Tonya Villafana, M. Pamela Griffin
Publikováno v:
Open Forum Infectious Diseases
Background RSV is the most common cause of lower respiratory tract infection (LRTI) among infants making prevention of RSV disease a public health priority. A significant unmet need exists for RSV prevention in healthy infants. Our goal is to develop
Autor:
Omar Ali, Therese Takas, Raburn M. Mallory, Filip Dubovsky, Kathryn M Jensen, Andrew C. Nyborg
Publikováno v:
Open Forum Infectious Diseases. 4:S519-S519