Výsledky vyhledávání - "Kathryn M Crotty"

Akademický článek

The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism

Autor: Felipe Paredes, Holly C. Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M. Crotty, Samantha M. Yeligar, Alvaro A. Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin

Publikováno v: Redox Biology, Vol 73, Iss , Pp 103203- (2024)

Vascular smooth muscle cells (VSMCs), known for their remarkable lifelong phenotypic plasticity, play a pivotal role in vascular pathologies through their ability to transition between different phenotypes. Our group discovered that the deficiency of

Externí odkaz: https://doaj.org/article/57f4954af63347f2a85440ad693065b8

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Akademický článek

Hyaladherins May be Implicated in Alcohol-Induced Susceptibility to Bacterial Pneumonia

Autor: Kathryn M. Crotty, Samantha M. Yeligar

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Although the epidemiology of bacterial pneumonia and excessive alcohol use is well established, the mechanisms by which alcohol induces risk of pneumonia are less clear. Patterns of alcohol misuse, termed alcohol use disorders (AUD), affect about 15

Externí odkaz: https://doaj.org/article/ed22c5acc1f14fbbae2da505ff5451f8

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Akademický článek

Alcohol-Induced Glycolytic Shift in Alveolar Macrophages Is Mediated by Hypoxia-Inducible Factor-1 Alpha

Autor: Niya L. Morris, David N. Michael, Kathryn M. Crotty, Sarah S. Chang, Samantha M. Yeligar

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Excessive alcohol use increases the risk of developing respiratory infections partially due to impaired alveolar macrophage (AM) phagocytic capacity. Previously, we showed that chronic ethanol (EtOH) exposure led to mitochondrial derangements and dim

Externí odkaz: https://doaj.org/article/40c9ad4f26f1450fb714c2535c03bcc0

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Alcohol and Immunology: Mechanisms of multi-organ damage. Summary of the 2022 alcohol and Immunology research interest group (AIRIG) meeting

Autor: Rachel H. McMahan, Paige Anton, Leon G. Coleman, Gail A.M. Cresci, Fulton T. Crews, Kathryn M. Crotty, Marisa E. Luck, Patricia E. Molina, Vidula Vachharajani, Joanne Weinberg, Samantha M. Yeligar, Mashkoor A. Choudhry, Rebecca L. McCullough, Elizabeth J. Kovacs

Publikováno v: Alcohol. 110:57-63

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::285b979eb5faf542c61fb0af19358ffd
https://doi.org/10.1016/j.alcohol.2023.04.002

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RGS14 is neuroprotective against seizure-induced mitochondrial oxidative stress and pathology in hippocampus

Autor: Nicholas H Harbin, Daniel J Lustberg, Cheyenne Hurst, Jean-Francois Pare, Kathryn M Crotty, Alaina L Waters, Samantha M Yeligar, Yoland Smith, Nicholas T Seyfried, David Weinshenker, John R Hepler

Publikováno v: bioRxiv

RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. There, RGS14 suppresses glutamate-induced calcium influx and related G protein and ERK signaling in dendritic spines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70874606f9291be226bad072cc47716
https://europepmc.org/articles/PMC9915580/