Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Kathryn Li"'
Autor:
Bandana Singh, Kathryn Li, Kui Cui, Qianman Peng, Douglas B. Cowan, Da-Zhi Wang, Kaifu Chen, Hong Chen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
The efficient phagocytic clearance of dying cells and apoptotic cells is one of the processes that is essential for the maintenance of physiologic tissue function and homeostasis, which is termed “efferocytosis.” Under normal conditions, “find
Externí odkaz:
https://doaj.org/article/d05b1a4ec9124b49a4a33eafe8200014
Autor:
Haipeng Guo, Yao Wei Lu, Zhiqiang Lin, Zhan-Peng Huang, Jianming Liu, Yi Wang, Hee Young Seok, Xiaoyun Hu, Qing Ma, Kathryn Li, Jan Kyselovic, Qingchuan Wang, Jenny L.-C. Lin, Jim J.-C. Lin, Douglas B. Cowan, Francisco Naya, Yuguo Chen, William T. Pu, Da-Zhi Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pat
Externí odkaz:
https://doaj.org/article/8da0d02d7d2444b1832b1613e9583e1a
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
There has been a rise in the prevalence of non-alcohol fatty liver disease (NAFLD) due to the popularity of western diets and sedentary lifestyles. One quarter of NAFLD patients is diagnosed with non-alcoholic steatohepatitis (NASH), with histologica
Externí odkaz:
https://doaj.org/article/c1ee281f0d274695b4540fb4acab641d
Autor:
Qianman Peng, Dan Shan, Kui Cui, Kathryn Li, Bo Zhu, Hao Wu, Beibei Wang, Scott Wong, Vikram Norton, Yunzhou Dong, Yao Wei Lu, Changcheng Zhou, Hong Chen
Publikováno v:
Cells, Vol 11, Iss 11, p 1834 (2022)
Endothelial-to-mesenchymal transition (EndoMT) is the process of endothelial cells progressively losing endothelial-specific markers and gaining mesenchymal phenotypes. In the normal physiological condition, EndoMT plays a fundamental role in forming
Externí odkaz:
https://doaj.org/article/da41ee7b858d4d91bf9d340968400091
Autor:
Yao Wei Lu, Zhuomin Liang, Haipeng Guo, Tiago Fernandes, Ramon A Espinoza-Lewis, Tingting Wang, Kathryn Li, Xue Li, Gurinder Bir Singh, Yi Wang, Douglas Cowan, John D Mably, Caroline C. Philpott, Hong Chen, Da-Zhi Wang
Publikováno v:
bioRxiv
SUMMARYAlanyl-transfer RNA synthetase 2 (AARS2) is a nuclear encoded mitochondrial tRNA synthetase that is responsible for charging of tRNA-Ala with alanine during mitochondrial translation. Homozygous or compound heterozygous mutations in the Aars2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35fe158576e973b3194a920d4daf491
https://doi.org/10.1101/2023.05.18.540420
https://doi.org/10.1101/2023.05.18.540420
Autor:
Yunzhou Dong, Beibei Wang, Mulong Du, Bo Zhu, Kui Cui, Kathryn Li, Ke Yuan, Douglas B. Cowan, Sudarshan Bhattacharjee, Scott Wong, Jinjun Shi, Da-Zhi Wang, Kaifu Chen, Joyce Bischoff, MacRae F. Linton, Hong Chen
Publikováno v:
Circulation.
Background: Epsin endocytic adaptor proteins are implicated in the progression of atherosclerosis; however, the underlying molecular mechanisms have not yet been fully defined. In this study, we determined how epsins enhance endothelial-to-mesenchyma
Autor:
Kui Cui, Xinlei Gao, Beibei Wang, Hao Wu, Kulandaisamy Arulsamy, Yunzhou Dong, Yuling Xiao, Xingya Jiang, Marina V. Malovichko, Kathryn Li, Qianman Peng, Yao Wei Lu, Bo Zhu, Rongbin Zheng, Scott Wong, Douglas B. Cowan, MacRae Linton, Sanjay Srivastava, Jinjun Shi, Kaifu Chen, Hong Chen
Publikováno v:
Circulation research. 132(1)
Background: Excess cholesterol accumulation in lesional macrophages elicits complex responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of atherosclerosis; however, the underlying mechanism and therapeutic poten
Autor:
Kui Cui, Xinlei Gao, Beibei Wang, Hao Wu, Yunzhou Dong, Yuling Xiao, Xingya Jiang, Marina V. Malovichko, Kathryn Li, Qianman Peng, Yaowei Lu, Bo Zhu, Rongbin Zheng, Scott Wong, Douglas B. Cowan, MacRae Linton, Sanjay Srivastava, Jinjun Shi, Kaifu Chen, Hong Chen
BACKGROUNDExcess cholesterol accumulation in lesional macrophages elicits complex responses in atherosclerosis. Epsins, a family of endocytic adaptors, fuel the progression of atherosclerosis; however, the underlying mechanism and therapeutic potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b146ecbcbc24af563e6d1690f9960c6
https://doi.org/10.1101/2022.08.09.503334
https://doi.org/10.1101/2022.08.09.503334
Autor:
Douglas B. Cowan, Qing Ma, Kathryn Li, Francisco J. Naya, Haipeng Guo, Yi Wang, Qingchuan Wang, Xiaoyun Hu, Zhiqiang Lin, Jianming Liu, Jan Kyselovic, Hee Young Seok, Da-Zhi Wang, Jenny Li-Chun Lin, Yao Wei Lu, William T. Pu, Zhan-Peng Huang, Yuguo Chen, Jim J.-C. Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Intercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. Mutations in genes encoding ICD components are linked to cardiovascular dis
Publikováno v:
Frontiers in Cardiovascular Medicine
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
There has been a rise in the prevalence of non-alcohol fatty liver disease (NAFLD) due to the popularity of western diets and sedentary lifestyles. One quarter of NAFLD patients is diagnosed with non-alcoholic steatohepatitis (NASH), with histologica