Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kathryn L. Schwienteck"'
Autor:
Kathryn L. Schwienteck, Travis W. Grim, Bruce E. Blough, S. Stevens Negus, Samuel Obeng, Kaycee E. Faunce, Matthew L. Banks, Yan Zhang, Kenner C. Rice
Publikováno v:
Neuropharmacology
One emerging strategy to address the opioid crisis is the development of mu opioid receptor (MOR) ligands that preferentially signal the G-protein vs. β-arrestin pathway. The present study compared the relative potency and effectiveness of two G-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc4c445be6c9642e8cc8663975837f3
https://doi.org/10.1016/j.neuropharm.2019.01.020
https://doi.org/10.1016/j.neuropharm.2019.01.020
Autor:
Hannah L. Robinson, Matthew L. Banks, Stephen T. Lawson, E. Andrew Townsend, Kathryn L. Schwienteck
Publikováno v:
J Neurosci Methods
Background Preclinical drug self-administration procedures are commonly used to investigate expression, mechanisms, and treatment of substance use disorders. New method The aims were to back-translate an intravenous drug-vs-food choice procedure prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf6e7bdb08fefedf9b975b422528b28
https://pubmed.ncbi.nlm.nih.gov/33705855
https://pubmed.ncbi.nlm.nih.gov/33705855
Publikováno v:
Substance Use Disorders
The foundational premise for all preclinical biomedical research is that results generated from nonhumans would be predictive of and consistent with results generated in humans. Preclinical procedures have been developed to model various aspects of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ec9e2165b4b22b842cbf89947f025e9
https://doi.org/10.1093/med/9780190920197.003.0003
https://doi.org/10.1093/med/9780190920197.003.0003
Autor:
Michael H. Baumann, John S. Partilla, S. Stevens Negus, Farhana Sakloth, Ernesto Solis, Kathryn L. Schwienteck, Iwona Ruchala, Louis J. De Felice, Richard A. Glennon, Jose M. Eltit
Publikováno v:
Neuropsychopharmacology. 42:1950-1961
Clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (DAT, NET, and SERT, respectively). 4-Methylamphetamine (4-MA) is an emerging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a328bddfdf60d37d43eec0f2a198dc0
https://doi.org/10.1038/npp.2017.98
https://doi.org/10.1038/npp.2017.98
Autor:
Guanguan Li, S. Stevens Negus, Kathryn L. Schwienteck, Michael M. Poe, Matthew L. Banks, James M. Cook
Publikováno v:
Psychopharmacology. 234:2091-2101
GABAA positive allosteric modulators (GABAA PAMs), such as diazepam and zolpidem, are used clinically for anxiety and insomnia, but abuse liability is a concern. Novel GABAA PAMS may have lower abuse liability while retaining clinical utility. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0a6e0f551ebe1e753782c80cd99068
https://doi.org/10.1007/s00213-017-4615-8
https://doi.org/10.1007/s00213-017-4615-8
Autor:
Kathryn L. Schwienteck, Paul T. Bremer, Matthew L. Banks, E. Andrew Townsend, Justin L. Poklis, S. Stevens Negus, Steven Blake
Publikováno v:
Drug Alcohol Depend
BackgroundOne emerging strategy to address the opioid crisis includes opioid-targeted immunopharmacotherapies. This study compared effectiveness of a heroin-tetanus toxoid (TT) conjugate vaccine to antagonize heroin, 6-acetylmorphine (6-AM), morphine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8de88a66e0681dd498f804fd5336bf
Autor:
David Stevens, Chongguang Chen, Abdulmajeed Jali, Yi Zheng, Hamid I. Akbarali, William L. Dewey, Kathryn L. Schwienteck, Huiqun Wang, Samuel Obeng, Yan Zhang, Lee-Yuan Liu-Chen, Mathew L. Banks, Dana E. Selley
The opioid crisis is a significant public health issue with more than 115 people dying from opioid overdose per day in the United States. The aim of the present study was to characterize the in vitro and in vivo pharmacological effects of 17-cyclopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f841d83e5551760200ad860cab6424aa
https://europepmc.org/articles/PMC6520168/
https://europepmc.org/articles/PMC6520168/
Publikováno v:
Drug and Alcohol Dependence. 155:16-23
Background Methamphetamine addiction is a significant public health problem for which no Food and Drug Administration-approved pharmacotherapies exist. Preclinical drug vs. food choice procedures have been predictive of clinical medication efficacy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17d49f2659807172ea8d86292c29936
https://doi.org/10.1016/j.drugalcdep.2015.08.022
https://doi.org/10.1016/j.drugalcdep.2015.08.022
Publikováno v:
Experimental and Clinical Psychopharmacology. 23:395-404
One complicating factor in cocaine addiction may be concurrent exposure and potential dependence on nicotine. The aim of the present study was to determine the effects of continuous nicotine treatment and subsequent termination on cocaine versus food
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b062bf96f71dd84690454458888042c
https://doi.org/10.1037/pha0000023
https://doi.org/10.1037/pha0000023
Publikováno v:
Current Treatment Options in Psychiatry. 2:136-150
Drug addiction is a disease that manifests as an inappropriate allocation of behavior towards the procurement and use of the abused substance and away from other behaviors that produce more adaptive reinforcers (e.g. exercise, work, family and social
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c3f639a458f67938aabf501b5ef532
https://doi.org/10.1007/s40501-015-0042-9
https://doi.org/10.1007/s40501-015-0042-9