Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kathryn L. Schornberg"'
Autor:
Charles J. Shoemaker, Kathryn L. Schornberg, Sue E. Delos, Corinne Scully, Hassan Pajouhesh, Gene G. Olinger, Lisa M. Johansen, Judith M. White
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/e9ff707137b94f6f833ef47273975822
Autor:
Charles J Shoemaker, Kathryn L Schornberg, Sue E Delos, Corinne Scully, Hassan Pajouhesh, Gene G Olinger, Lisa M Johansen, Judith M White
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56265 (2013)
Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providin
Externí odkaz:
https://doaj.org/article/e41b76c3bdb5499fbd5498b5ccc2905a
Autor:
James E. Casanova, James A. Simmons, Rebecca M. Mingo, Ryan S. D'Souza, Elizabeth A. Nelson, Judith M. White, Charles J. Shoemaker, Kathryn L. Schornberg
Publikováno v:
Journal of Virology
Ebola virus (EBOV) causes hemorrhagic fevers with high mortality rates. During cellular entry, the virus is internalized by macropinocytosis and trafficked through endosomes until fusion between the viral and an endosomal membrane is triggered, relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e98965836ae4da13d48f065d3a931af9
https://doi.org/10.1128/jvi.03398-14
https://doi.org/10.1128/jvi.03398-14
Autor:
Sue E. Delos, Kathryn L. Schornberg, Erica Ollmann Saphire, Matthew Brecher, Marnie L. Fusco, Judith M. White
Publikováno v:
Journal of Virology
Cellular entry of Ebola virus (EBOV), a deadly hemorrhagic fever virus, is mediated by the viral glycoprotein (GP). The receptor-binding subunit of GP must be cleaved (by endosomal cathepsins) in order for entry and infection to proceed. Cleavage app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46707dcb4a58860ff0acf023ae0aedf
Autor:
Judith M. White, Michelle Y. Abshire, Derek Dube, Amy H. Bouton, Charles J. Shoemaker, Sue E. Delos, Kathryn L. Schornberg
Publikováno v:
Proceedings of the National Academy of Sciences
Integrins are involved in the binding and internalization of both enveloped and nonenveloped viruses. By using 3 distinct cell systems—CHO cells lacking expression of α 5 β 1 -integrin, HeLa cells treated with siRNA to α 5 -integrin, and mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b85fdbedf65e62b381d1c022a5b4955
https://doi.org/10.1073/pnas.0807578106
https://doi.org/10.1073/pnas.0807578106
Autor:
Edward W. Park, Matthew Brecher, Sue E. Delos, Judith M. White, Jens H. Kuhn, Sean C. Rose, Kathryn L. Schornberg, Derek Dube
Publikováno v:
Journal of Virology. 83:2883-2891
Entry of ebolavirus (EBOV) into cells is mediated by its glycoprotein (GP 1,2 ), a class I fusion protein whose structure was recently determined (J. E. Lee et al., Nature 454: 177-182, 2008). Here we confirmed two major predictions of the structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf68f0f9c69a98ad474cb45ba21550ed
https://doi.org/10.1128/jvi.01956-08
https://doi.org/10.1128/jvi.01956-08
Autor:
Matthew I. Bonaparte, Tzanko S. Stantchev, Christopher C. Broder, Sue E. Delos, Judith M. White, Derek Dube, Amy H. Bouton, Kathryn L. Schornberg
Publikováno v:
Journal of Virology. 82:7238-7242
Ebola virus infects a wide variety of adherent cell types, while nonadherent cells are found to be refractory. To explore this correlation, we compared the ability of pairs of related adherent and nonadherent cells to bind a recombinant Ebola virus r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43784f1d79626bf811141ae477600c3d
https://doi.org/10.1128/jvi.00425-08
https://doi.org/10.1128/jvi.00425-08
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology
Recent work has identified three distinct classes of viral membrane fusion proteins based on structural criteria. In addition, there are at least four distinct mechanisms by which viral fusion proteins can be triggered to undergo fusion-inducing conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b7070847d7eb9e06b7506617427dd4
https://doi.org/10.1080/10409230802058320
https://doi.org/10.1080/10409230802058320
Autor:
Amy H. Bouton, Judith M. White, Shutoku Matsuyama, Sue E. Delos, Kirsten Kabsch, Kathryn L. Schornberg
Publikováno v:
Journal of Virology
Using chemical inhibitors and small interfering RNA (siRNA), we have confirmed roles for cathepsin B (CatB) and cathepsin L (CatL) in Ebola virus glycoprotein (GP)-mediated infection. Treatment of Ebola virus GP pseudovirions with CatB and CatL conve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b02312eb44d281ff2dcd3d18ae0fcc
https://doi.org/10.1128/jvi.80.8.4174-4178.2006
https://doi.org/10.1128/jvi.80.8.4174-4178.2006
Autor:
Lisa Evans DeWald, Jennifer M. Brannan, Judith M. White, Benjamin G. Hoffstrom, Joseph Lehar, Gene G. Olinger, Kathryn L. Schornberg, Andrea Stossel, Corinne Scully, Charles J. Shoemaker, Lisa E. Hensley, Lisa M. Johansen, Calli Lear, Sue E. Delos
Publikováno v:
Science Translational Medicine. 5
Ebola viruses remain a substantial threat to both civilian and military populations as bioweapons, during sporadic outbreaks, and from the possibility of accidental importation from endemic regions by infected individuals. Currently, no approved ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1031ce29c70d907a9432e8783c2197a6
https://doi.org/10.1126/scitranslmed.3005471
https://doi.org/10.1126/scitranslmed.3005471