Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Kathryn L. Reichard"'
Autor:
Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enha
Externí odkaz:
https://doaj.org/article/663c11deb7974a19a4ce19a91ea13d73
Autor:
Selena S. Schattauer, Paulo M. Sotero de Menezes, Kathryn L. Reichard, Charles Chavkin, Zeena M. G. Rivera, Keionna A. Newton, Benjamin B. Land
Publikováno v:
Mol Pharmacol
The prototypical member of the receptor-inactivating kappa opioid receptor (KOR) antagonists, norbinaltorphimine (norBNI), produces prolonged receptor inactivation by a cJun kinase mechanism. These antagonists have potential therapeutic utility in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5daa49e40cc4d039c528069a1301f699
https://europepmc.org/articles/PMC7569314/
https://europepmc.org/articles/PMC7569314/
Autor:
Kathryn L. Reichard, Marta E. Soden, Naomi McFarland, Charles Chavkin, Yong Sang Jo, Larry S. Zweifel, Gabriel Heymann, Richard D. Palmiter
Publikováno v:
Neuron
Dopamine neurons of the ventral tegmental area (VTA) regulate reward association and motivation. It remains unclear whether there are distinct dopamine populations to mediate these functions. Using mouse genetics, we isolated two populations of dopam
Autor:
Salina D. Johnson, Benjamin B. Land, Allisa J. Song, Kathryn L. Reichard, Harrison M. Fontaine, Charles Chavkin, Joshua H Cohen, Antony D. Abraham, Selena S. Schattauer
Activation of κ opioid receptors (KORs) produces analgesia and aversion via distinct intracellular signaling pathways, but whether G protein-biased KOR agonists can be designed to have clinical utility will depend on a better understanding of the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b570cfbff6426e163891ed7b1d8020aa
https://europepmc.org/articles/PMC6136151/
https://europepmc.org/articles/PMC6136151/
Autor:
Shao En Ong, Selena S. Schattauer, Lauren M. Burgeno, Jamie R. Kuhar, Charles Chavkin, Paul E. M. Phillips, Kathryn L. Reichard, Benjamin B. Land, Antony D. Abraham
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioid antidepressants by an uncharacterized, arrestin-independent mechanism. Here we use an iterative, discovery-bas
Autor:
Anthony E. Gioio, Kazu Nakazawa, Barry B. Kaplan, Kathryn L. Reichard, Ching-Yu Sun, Amar N. Kar, James Pickel, Noreen M. Gervasi
Publikováno v:
Developmental Neurobiology. 74:333-350
Local translation of nuclear-encoded mitochondrial mRNAs is essential for mitochondrial activity, yet there is little insight into the role that axonal trafficking of these transcripts play in neuronal function and behavior. Previously, we identified