Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kathryn L. Pothoven"'
Autor:
Masafumi Sakashita, Tetsuji Takabayashi, Yoshimasa Imoto, Tetsuya Homma, Kanako Yoshida, Kazuhiro Ogi, Yukihiro Kimura, Atsushi Kato, Whitney W. Stevens, Stephanie S. Smith, Kevin C. Welch, James E. Norton, Lydia A. Suh, Roderick G. Carter, Kathryn E. Hulse, Sudarshan Seshadri, Jin-Young Min, Kathryn L. Pothoven, David B. Conley, Bruce K. Tan, Kathleen E. Harris, Robert C. Kern, Shinichi Haruna, Yoshinori Matsuwaki, Ryosuke Ochiai, Shigeharu Fujieda, Robert P. Schleimer
Publikováno v:
The Journal of allergy and clinical immunology. 150(5)
Patients with aspirin-exacerbated respiratory disease (AERD) regularly exhibit severe nasal polyposis. Studies suggest that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition associated with a profound d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7986f6a9dc5f6cce967848f4280c8573
https://pubmed.ncbi.nlm.nih.gov/35728655
https://pubmed.ncbi.nlm.nih.gov/35728655
Publikováno v:
Tissue barriers. 5(3)
Mucosal epithelium maintains tissue homeostasis through many processes, including epithelial barrier function, which separates the environment from the tissue. The barrier hypothesis of type 2 inflammatory disease postulates that epithelial and epide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad55339dace1474fb2a46e11cc3ff355
https://pubmed.ncbi.nlm.nih.gov/28665760
https://pubmed.ncbi.nlm.nih.gov/28665760
Autor:
Zheng Zhang, Nadine M. Lerret, Taba Kheradmand, J. L. Houlihan, Xunrong Luo, Kathryn L. Pothoven
Publikováno v:
American Journal of Transplantation. 12:2335-2347
CD4(+) regulatory T cells play a critical role in tolerance induction in transplantation. CD8(+) suppressor T cells have also been shown to control alloimmune responses in preclinical and clinical models. However, the exact nature of the CD8(+) suppr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a97b1192c4289fcc893ae9cc0d02ad
https://doi.org/10.1111/j.1600-6143.2012.04120.x
https://doi.org/10.1111/j.1600-6143.2012.04120.x
Autor:
J. L. Houlihan, Zheng Zhang, Shusen Wang, Stephen D. Miller, James Tasch, Nadine M. Lerret, Kathryn L. Pothoven, Taba Kheradmand, Jane Bryant, Xunrong Luo
Publikováno v:
The Journal of Immunology. 189:804-812
Strategic exposure to donor Ags prior to transplantation can be an effective way for inducting donor-specific tolerance in allogeneic recipients. We have recently shown that pretransplant infusion of donor splenocytes treated with the chemical cross-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9a5b21707462f5d3526bb5da1270a6
https://doi.org/10.4049/jimmunol.1103705
https://doi.org/10.4049/jimmunol.1103705
Autor:
Kathryn L. Pothoven, Taba Kheradmand, M. DeGutes, J. L. Houlihan, H. Zhang, Xunrong Luo, Stephen D. Miller, Q. Yang
Publikováno v:
American Journal of Transplantation. 10:1774-1784
Dendritic cells (DCs) conditioned with the mammalian target of rapamycin (mTOR) inhibitor rapamycin have been previously shown to expand naturally existing regulatory T cells (nTregs). This work addresses whether rapamycin-conditioned donor DCs could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7836c8bea46be5f564e9439499e38084
https://doi.org/10.1111/j.1600-6143.2010.03199.x
https://doi.org/10.1111/j.1600-6143.2010.03199.x
Autor:
Aaron Martin, Mathew DeGutes, Daniel R. Getts, Jie He, Dixon B. Kaufman, Stephen D. Miller, Derrick P. McCarthy, Kathryn L. Pothoven, Xiaomin Zhang, Guliang Xia, Xunrong Luo
Publikováno v:
Proceedings of the National Academy of Sciences. 105:14527-14532
A major challenge for human allogeneic islet transplantation is the development of effective methods to induce donor-specific tolerance to obviate the need for life-long immunosuppression that is toxic to the insulin-producing β cells and detrimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de78c2c442ba493eda510c0a5c6de42e
https://doi.org/10.1073/pnas.0805204105
https://doi.org/10.1073/pnas.0805204105
Publikováno v:
The Journal of Immunology. 180:2757-2761
The peripheral induction of T regulatory cells can be accomplished by TGF-β through an epigenetic regulation leading to the expression of Foxp3. However, the exact mechanism of such a TGF-β-mediated action remains unclear. In the current study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d52767637fc5518c93716d60cd0c124
https://doi.org/10.4049/jimmunol.180.5.2757
https://doi.org/10.4049/jimmunol.180.5.2757
Autor:
Qutayba Hamid, James E. Norton, Kevin C. Welch, Bruce K. Tan, Stephanie Shintani-Smith, Kathleen E. Harris, Robert P. Schleimer, Leslie C. Grammer, Lydia Suh, Mark C. Liu, Assel Biyasheva, Pedro C. Avila, Anju T. Peters, David B. Conley, Atsushi Kato, Roderick G. Carter, Kathryn L. Pothoven, Robert C. Kern
Publikováno v:
Journal of Allergy and Clinical Immunology. 139:1966-1978.e9
Background We have previously shown that oncostatin M (OSM) levels are increased in nasal polyps (NPs) of patients with chronic rhinosinusitis (CRS), as well as in bronchoalveolar lavage fluid, after segmental allergen challenge in allergic asthmatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d8190adfef9076e244588133773871
https://doi.org/10.1016/j.jaci.2016.10.039
https://doi.org/10.1016/j.jaci.2016.10.039
Autor:
Leslie C. Grammer, Kathryn E. Hulse, Robert C. Kern, Caroline P.E. Price, Bruce K. Tan, Robert P. Schleimer, Jin Young Min, Nikolai N. Modyanov, Atsushi Kato, Lydia Suh, David B. Conley, Kathleen E. Harris, Kathryn L. Pothoven, Christopher F. Thompson, Whitney W. Stevens, Tetsuya Homma, Kevin C. Welch, James E. Norton, Stephanie Shintani-Smith, Anju T. Peters, Christopher J. Ocampo, Julia H. Huang
Publikováno v:
Journal of Allergy and Clinical Immunology. 139:130-141.e11
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is often characterized by tissue eosinophilia that is associated with poor prognosis. Recent findings that proton pump inhibitors (PPIs) directly modulate the expression of eotaxin-3, an eo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04563dd03467d094df205a3ff73c0f64
https://doi.org/10.1016/j.jaci.2016.07.020
https://doi.org/10.1016/j.jaci.2016.07.020
Autor:
Stephanie Shintani-Smith, David B. Conley, Bruce K. Tan, Paul J. Bryce, Robert P. Schleimer, Leslie C. Grammer, Rakesh K. Chandra, Mark C. Liu, James E. Norton, Robert C. Kern, Anju T. Peters, Kathryn E. Hulse, Kathleen E. Harris, Nirmala Gonsalves, Atsushi Kato, Roderick G. Carter, Kathryn L. Pothoven, Erin Rocci, Lydia Suh
Publikováno v:
The Journal of allergy and clinical immunology. 136(3)
Epithelial barrier dysfunction is thought to play a role in many mucosal diseases, including asthma, chronic rhinosinusitis (CRS), and eosinophilic esophagitis.The objective of this study was to investigate the role of oncostatin M (OSM) in epithelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8396ee7804872f9744bfef4f6cab2b1
https://pubmed.ncbi.nlm.nih.gov/25840724
https://pubmed.ncbi.nlm.nih.gov/25840724