Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kathryn L Shelley"'
Autor:
Amy C. Thomas, Elizabeth Oliver, Holly E. Baum, Kapil Gupta, Kathryn L. Shelley, Anna E. Long, Hayley E. Jones, Joyce Smith, Benjamin Hitchings, Natalie di Bartolo, Kate Vasileiou, Fruzsina Rabi, Hanin Alamir, Malak Eghleilib, Ore Francis, Jennifer Oliver, Begonia Morales-Aza, Ulrike Obst, Debbie Shattock, Rachael Barr, Lucy Collingwood, Kaltun Duale, Niall Grace, Guillaume Gonnage Livera, Lindsay Bishop, Harriet Downing, Fernanda Rodrigues, Nicholas Timpson, Caroline L. Relton, Ashley Toye, Derek N. Woolfson, Imre Berger, Anu Goenka, Andrew D. Davidson, Kathleen M. Gillespie, Alistair J. K. Williams, Mick Bailey, Ellen Brooks-Pollock, Adam Finn, Alice Halliday, the CoMMinS Study Team
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Thomas et al. test 6 ELISAs detecting IgA and IgG antibodies to whole SARS-CoV-2 spike protein, to its receptor binding domain region and to nucleocapsid protein in saliva. Across 20 household outbreaks, antibody responses are heterogeneous, but a re
Externí odkaz:
https://doaj.org/article/55c6b79ee60943e99ecc0c4b2dc196bb
Autor:
William M. Dawson, Kathryn L. Shelley, Jordan M. Fletcher, D. Arne Scott, Lucia Lombardi, Guto G. Rhys, Tania J. LaGambina, Ulrike Obst, Antony J. Burton, Jessica A. Cross, George Davies, Freddie J. O. Martin, Francis J. Wiseman, R. Leo Brady, David Tew, Christopher W. Wood, Derek N. Woolfson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Differential sensing aims to mimic senses such as taste and smell through the use of synthetic receptors. Here, the authors show that arrays of de novo designed peptide assemblies can be used as sensor components to distinguish various analytes and c
Externí odkaz:
https://doaj.org/article/a820f403adc549ffa2b3bf2e841354ca
Autor:
Kathryn L. Shelley, Elspeth F. Garman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Radiation damage hampers protein structure determination by X-ray crystallography. Here, the AUs introduce the B net metric, a single value summarising the extent of radiation damage of a protein crystal structure, and use B net to detect radiation d
Externí odkaz:
https://doaj.org/article/d78b9a058c394595a8a1d93af0d1cec7
Autor:
Alice Halliday, Anna E. Long, Holly E. Baum, Amy C. Thomas, Kathryn L. Shelley, Elizabeth Oliver, Kapil Gupta, Ore Francis, Maia Kavanagh Williamson, Natalie Di Bartolo, Matthew J. Randell, Yassin Ben-Khoud, Ilana Kelland, Georgina Mortimer, Olivia Ball, Charlie Plumptre, Kyla Chandler, Ulrike Obst, Massimiliano Secchi, Lorenzo Piemonti, Vito Lampasona, Joyce Smith, Michaela Gregorova, Lea Knezevic, Jane Metz, Rachael Barr, Begonia Morales-Aza, Jennifer Oliver, Lucy Collingwood, Benjamin Hitchings, Susan Ring, Linda Wooldridge, Laura Rivino, Nicholas Timpson, Jorgen McKernon, Peter Muir, Fergus Hamilton, David Arnold, Derek N. Woolfson, Anu Goenka, Andrew D. Davidson, Ashley M. Toye, Imre Berger, Mick Bailey, Kathleen M. Gillespie, Alistair J. K. Williams, Adam Finn
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Low-volume antibody assays can be used to track SARS-CoV-2 infection rates in settings where active testing for virus is limited and remote sampling is optimal. We developed 12 ELISAs detecting total or antibody isotypes to SARS-CoV-2 nucleocapsid, s
Externí odkaz:
https://doaj.org/article/305a69f5b981428bab7c739f99a8b141
Autor:
William M. Dawson, Eric J. M. Lang, Guto G. Rhys, Kathryn L. Shelley, Christopher Williams, R. Leo Brady, Matthew P. Crump, Adrian J. Mulholland, Derek N. Woolfson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
So far most of the de novo designed proteins are for single states only. Here, the authors present the de novo design and crystal structure determination of a coiled-coil peptide that assembles into multiple, distinct conformational states under the
Externí odkaz:
https://doaj.org/article/da6fbe49cbb74470820dc44739bd5079
Autor:
Guto G. Rhys, William M. Dawson, Derek N. Woolfson, Freddie J. O. Martin, R. Leo Brady, Kathryn L Shelley
Publikováno v:
Dawson, W M, Martin, F J O, Rhys, G G, Shelley, K L, Brady, R L & Woolfson, D N 2021, ' Coiled coils 9-to-5 : rational de novo design of α-helical barrels with tunable oligomeric states ', Chemical Science, vol. 12, no. 20, pp. 6923-6928 . https://doi.org/10.1039/d1sc00460c
The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures and avoid alternative states. However, the non-covalent forces that stabilize and discrimi
Autor:
Kathryn L, Shelley, Elspeth F, Garman
Publikováno v:
Nature communications. 13(1)
Radiation damage remains one of the major bottlenecks to accurate structure solution in protein crystallography. It can induce structural and chemical changes in protein crystals, and is hence an important consideration when assessing the quality and
Autor:
Christopher Williams, William M. Dawson, Adrian J. Mulholland, Matthew P. Crump, R. Leo Brady, Eric J. M. Lang, Kathryn L Shelley, Guto G. Rhys, Derek N. Woolfson
Publikováno v:
Nature Communications
Dawson, W M, Lang, E J M, Rhys, G G, Shelley, K L, Williams, C, Brady, R L, Crump, M P, Mulholland, A J & Woolfson, D N 2021, ' Structural resolution of switchable states of a de novo peptide assembly ', Nature Communications, vol. 12, no. 1, 1530 (2020) . https://doi.org/10.1038/s41467-021-21851-8
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Dawson, W M, Lang, E J M, Rhys, G G, Shelley, K L, Williams, C, Brady, R L, Crump, M P, Mulholland, A J & Woolfson, D N 2021, ' Structural resolution of switchable states of a de novo peptide assembly ', Nature Communications, vol. 12, no. 1, 1530 (2020) . https://doi.org/10.1038/s41467-021-21851-8
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
De novo protein design is advancing rapidly. However, most designs are for single states. Here we report a de novo designed peptide that forms multiple α-helical-bundle states that are accessible and interconvertible under the same conditions. Usual
Autor:
William M, Dawson, Freddie J O, Martin, Guto G, Rhys, Kathryn L, Shelley, R Leo, Brady, Derek N, Woolfson
Publikováno v:
Chemical Science
The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures and avoid alternative states. However, the non-covalent forces that stabilize and discrimi
Autor:
William M. Dawson, Freddie J. O. Martin, Derek N. Woolfson, Kathryn L Shelley, Guto G. Rhys, R. Leo Brady
The rational design of linear peptides that assemble controllably and predictably in water is challenging. Sequences must encode unique target structures and avoid alternative states. However, the stabilizing and discriminating non-covalent forces av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::166d59cbb2f381b7920e69a53824066c
https://doi.org/10.1101/2021.01.20.427391
https://doi.org/10.1101/2021.01.20.427391