Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Kathryn L Lipson"'
Autor:
Agata Jurczyk, Steven C Pino, Bryan O'Sullivan-Murphy, Martha Addorio, Erich A Lidstone, Philip Diiorio, Kathryn L Lipson, Clive Standley, Kevin Fogarty, Lawrence Lifshitz, Fumihiko Urano, John P Mordes, Dale L Greiner, Aldo A Rossini, Rita Bortell
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11812 (2010)
The centrosome is important for microtubule organization and cell cycle progression in animal cells. Recently, mutations in the centrosomal protein, pericentrin, have been linked to human microcephalic osteodysplastic primordial dwarfism (MOPD II), a
Externí odkaz:
https://doaj.org/article/87eb60336d2e4579be48ca104bae968e
Autor:
Rajarshi Ghosh, Kathryn L Lipson, Karen E Sargent, Arthur M Mercurio, Joan S Hunt, David Ron, Fumihiko Urano
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9575 (2010)
Angiogenesis is crucial to many physiological and pathological processes including development and cancer cell survival. Vascular endothelial growth factor-A (VEGFA) is the predominant mediator of angiogenesis in the VEGF family. During development,
Externí odkaz:
https://doaj.org/article/8fdbad546e3e47adb70f5a55aa59062d
Autor:
Steven C Pino, Bryan O'Sullivan-Murphy, Erich A Lidstone, Chaoxing Yang, Kathryn L Lipson, Agata Jurczyk, Philip diIorio, Michael A Brehm, John P Mordes, Dale L Greiner, Aldo A Rossini, Rita Bortell
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5468 (2009)
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the
Externí odkaz:
https://doaj.org/article/b47c27fdea4649c3bca3dcc7d7cff892
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1648 (2008)
The endoplasmic reticulum (ER) is a cellular compartment for the biosynthesis and folding of newly synthesized secretory proteins such as insulin. Perturbations to ER homeostasis cause ER stress and subsequently activate cell signaling pathways, coll
Externí odkaz:
https://doaj.org/article/4547342d731c45c8a93b7ab2e641b503
Publikováno v:
Antioxidants & Redox Signaling. 9:2335-2344
Pancreatic beta-cells are specialized for the production and regulated secretion of insulin to control blood-glucose levels. Increasing evidence indicates that stress-signaling pathways emanating from the endoplasmic reticulum (ER) are important in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ee160658ec24125a4bbd0191803eab
https://doi.org/10.1089/ars.2007.1790
https://doi.org/10.1089/ars.2007.1790
Autor:
Shinsuke Ishigaki, Kathryn L. Lipson, Sonya G. Fonseca, Linh X. Nguyen, Fumihiko Urano, Elizabeth Foss, Rita Bortell, Aldo A. Rossini
Publikováno v:
Cell Metabolism. 4(3):245-254
In pancreatic beta cells, the endoplasmic reticulum (ER) is an important site for insulin biosynthesis and the folding of newly synthesized proinsulin. Here, we show that IRE1alpha, an ER-resident protein kinase, has a crucial function in insulin bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e2834380424877dc575a7a7763ca46
Autor:
Fumihiko Urano, Jenny R. Allen, Linh X. Nguyen, Yoshitomo Oka, Sonya G. Fonseca, Mariko Fukuma, Kathryn L. Lipson
Publikováno v:
Journal of Biological Chemistry. 280:39609-39615
In Wolfram syndrome, a rare form of juvenile diabetes, pancreatic beta-cell death is not accompanied by an autoimmune response. Although it has been reported that mutations in the WFS1 gene are responsible for the development of this syndrome, the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae25ecb3c891cc1433276b8e8f7c4d3
https://doi.org/10.1074/jbc.m507426200
https://doi.org/10.1074/jbc.m507426200
Autor:
Kathryn L. Lipson, Jenny R. Allen, Fumihiko Urano, Linh X. Nguyen, Anthony Hackett, Karen E. Sargent
Publikováno v:
Biochemical and Biophysical Research Communications. 324:166-170
Endoplasmic reticulum (ER) stress, which is caused by the accumulation of misfolded proteins in the ER, elicits an adaptive response, the unfolded protein response (UPR). One component of the UPR, the endoplasmic reticulum-associated protein degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd3eda2dae96afebbc7e5f7ca1378c1
https://doi.org/10.1016/j.bbrc.2004.09.035
https://doi.org/10.1016/j.bbrc.2004.09.035
Autor:
Iris Lindberg, Doris A. Stoffers, Raghavendra G. Mirmira, Sindhu Rajan, Chong Wee Liew, Allison B. Goldfine, Nahum Sonenberg, Rohit N. Kulkarni, Louis H. Philipson, Jeffrey C. Raum, Kathryn L. Lipson, Andrew T. Templin, Anke Assmann, Dan Kawamori, Jiang Hu, Guifen Qiang, Fumihiko Urano
Publikováno v:
Proceedings of the National Academy of Sciences. 111
Insulin resistance, hyperinsulinemia, and hyperproinsulinemia occur early in the pathogenesis of type 2 diabetes (T2D). Elevated levels of proinsulin and proinsulin intermediates are markers of β-cell dysfunction and are strongly associated with dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b9870f5099a5671f57e648bb520aa0
https://doi.org/10.1073/pnas.1323066111
https://doi.org/10.1073/pnas.1323066111
Publikováno v:
Endoplasmic Reticulum Stress in Health and Disease ISBN: 9789400743502
Recent clinical, genetic and experimental evidence indicates that dysregulation of endoplasmic reticulum (ER) homeostasis plays an important role in the pathogenesis of neurodegenerative diseases and psychiatric illness. Protein flux through the ER m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7bd8a302bddd754b6cba1204ba426ec
https://doi.org/10.1007/978-94-007-4351-9_13
https://doi.org/10.1007/978-94-007-4351-9_13
