Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kathryn L, Kavanagh"'
Autor:
Kathryn L. Kavanagh, T. Krojer, João R. C. Muniz, S.S. Ng, Michael A. McDonough, Rok Sekirnik, Nadia J. Kershaw, Wei Ge, Aidan J. Doherty, Christopher J. Schofield, Chia-hua Ho, Ewa S. Pilka, Ian J. Clifton, Rasheduzzaman Chowdhury, Udo Oppermann, Gavin C. Fox, M. Vollmar, Claire Phillips, Frank von Delft, Nigel C. Brissett
Publikováno v:
Nature
Crystal structures of human and prokaryotic ribosomal oxygenases reported here, with and without their ribosomal protein substrates, support their assignments as hydroxylases, and provide insights into the evolution of the JmjC-domain-containing hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5419a93034e4f468b7cfd6cd5727ba0d
https://doi.org/10.1038/nature13263
https://doi.org/10.1038/nature13263
Autor:
Timothy Searls, Kathryn L. Kavanagh, Udo Oppermann, Michael A. McDonough, Danica Butler, Christopher J. Schofield
Refsum disease (RD), a neurological syndrome characterized by adult onset retinitis pigmentosa, anosmia, sensory neuropathy, and phytanic acidaemia, is caused by elevated levels of phytanic acid. Many cases of RD are associated with mutations in phyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30c0ca4b63f2071d7bb84de101270b5
https://doi.org/10.1074/jbc.m507528200
https://doi.org/10.1074/jbc.m507528200
Autor:
Opher Gileadi, Udo Oppermann, Kathryn L. Kavanagh, John Offer, S.S. Ng, Michael Sundström, Johanna C. Scheinost, Tomasz Borowski, Michael A. McDonough, Ewa S. Pilka, Benoît M. R. Liénard, Frank von Delft, Pavel Savitsky, James E. Bray, Danica Butler, Christopher J. Schofield, Nathan R. Rose
Post-translational histone modification has a fundamental role in chromatin biology and is proposed to constitute a 'histone code' in epigenetic regulation. Differential methylation of histone H3 and H4 lysyl residues regulates processes including he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65e65c66328fd56f1cc462b7b2d12a6
https://ora.ox.ac.uk/objects/uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
https://ora.ox.ac.uk/objects/uuid:545da9d0-2eec-44f0-b3e8-fdd00c4f13cd
Autor:
Celia J. Webby, Michael A. McDonough, Eleanor A.L. Bagg, T. Krojer, Kathryn L. Kavanagh, Danica Butler, Christopher J. Schofield, Monica Mantri, Grazyna Kochan, Udo Oppermann
Lysyl and prolyl hydroxylations are well-known post-translational modifications to animal and plant proteins with extracellular roles. More recent work has indicated that the hydroxylation of intracellular animal proteins may be common. JMJD6 catalys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f144cb15e40f628abb21964256b143
https://doi.org/10.1016/j.jmb.2010.05.054
https://doi.org/10.1016/j.jmb.2010.05.054
Autor:
Viktorija Hozjan, Wyatt W. Yue, Michael A. McDonough, Christopher D.O. Cooper, Udo Oppermann, Christopher J. Schofield, Christoph Loenarz, Wei Ge, Kathryn L. Kavanagh
Crystallographic analysis of the catalytic domain of PHD finger protein 8 (PHF8), an N(epsilon)-methyl lysine histone demethylase associated with mental retardation and cleft lip/palate, reveals a double-stranded beta-helix fold with conserved Fe(II)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf232b4890e090eae6e3cd67e10866
https://ora.ox.ac.uk/objects/uuid:277d0481-0543-471d-8189-ee91e577da27
https://ora.ox.ac.uk/objects/uuid:277d0481-0543-471d-8189-ee91e577da27
Publikováno v:
Cellular and Molecular Life Sciences
Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. SDR enzymes have critical roles in lipid, amino acid, carbohydrate, cofactor, ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5beea8807ff1257a57b0f8ab8796f8d
https://ora.ox.ac.uk/objects/uuid:330452c0-d69d-4f2a-8c0a-40e38a10a1b7
https://ora.ox.ac.uk/objects/uuid:330452c0-d69d-4f2a-8c0a-40e38a10a1b7
SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy
Autor:
Paul J. A. Michiels, Kathryn L. Kavanagh, Christian Ludwig, Udo Oppermann, Ulrich L. Günther, Anna Jansson, Ewa S. Pilka, Xiaoqiu Wu
Quinone oxidoreductase 2 (NQO2) binds the prodrug tretazicar (also known as CB1954, 5-(aziridin-1-yl)-2,4-dinitrobenzamide), which exhibits a profound antitumor effect in human cancers when administered together with caricotamide. X-ray structure det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1e539118980438f1f9e1d430e07d96
https://doi.org/10.1021/jm701020f
https://doi.org/10.1021/jm701020f
Hydroxysteroid dehydrogenases catalyze the NAD(P)(H)-dependent oxidoreduction of hydroxyl and oxo-functions at distinct positions of steroid hormones. This reversible reaction constitutes an important pre-receptor control mechanism for nuclear recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5556000750a823d7d6620c04a0057a7d
https://doi.org/10.1016/j.mce.2006.12.006
https://doi.org/10.1016/j.mce.2006.12.006
Publikováno v:
The Journal of Biological Chemistry
Elevated production of the matrix glycosaminoglycan hyaluronan is strongly implicated in epithelial tumor progression. Inhibition of synthesis of the hyaluronan precursor UDP-glucuronic acid (UDP-GlcUA) therefore presents an emerging target for cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b3eea4bd3e7899662a714ca20755af
https://doi.org/10.1074/jbc.m111.234682
https://doi.org/10.1074/jbc.m111.234682