Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers

Autor: Kathryn J. Schunke, PhD, Lauren M. Rosati, BS, Marianna Zahurak, MS, Joseph M. Herman, MD, MSc, Amol K. Narang, MD, Irina Usach, Alison P. Klein, MHS, PhD, Charles J. Yeo, MD, Larry T. Korman, BSN, Ralph H. Hruban, MD, John L. Cameron, MD, Daniel A. Laheru, MD, Ross A. Abrams, MD

Publikováno v: Advances in Radiation Oncology, Vol 3, Iss 1, Pp 42-51 (2018)

Purpose: The purpose of this study was to report toxicity and long-term survival outcomes of 2 prospective trials evaluating mitomycin C (MMC) with 5-fluorouracil–based adjuvant chemoradiation in resected periampullary adenocarcinoma. Methods and m

Externí odkaz: https://doaj.org/article/70f9f35e04b1417eaac32619b7d7d0c1

Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure

Autor: John Schloen, Joan B. Escobar, Christopher F. Spurney, Olga Dergacheva, Xin Wang, Kyung-Min Lee, Kathryn J Schunke, Lisete Compagno Michelini, Whitney Wolaver, Jhansi Dyavanapalli, Carla Rocha dos Santos, Jeannette Rodriguez, Mary Kate Dwyer, David Mendelowitz, Matthew W. Kay

Publikováno v: JACC: Basic to Translational Science
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Visual Abstract
Highlights • Hypothalamic OXT neurons were chronically activated using a chemogenetic approach in an animal model of HF. • Synaptic release of OXT onto parasympathetic autonomic targets was reduced in animals with HF but rest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26189fd760c30830ef72f5892b159145
http://europepmc.org/articles/PMC7251188

HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction

Autor: Abigail Avelar, Ralph V. Shohet, Kathryn J Schunke, Allison L Williams, Vedbar S. Khadka, Mingxin Tang, Mark Menor

Publikováno v: Physiological Genomics. 50:479-494

Alternative splicing of RNA is an underexplored area of transcriptional response. We expect that early changes in alternatively spliced genes may be important for responses to cardiac injury. Hypoxia inducible factor 1 (HIF1) is a key transcription f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95f2ed6189fae853f53ef7c41f6678e
https://doi.org/10.1152/physiolgenomics.00130.2017

Abstract 307: Chemogenetic Activation of Paraventricular Oxytocin Neurons Reduces Cardiac Dysfunction During Heart Failure

Autor: Mary Kate Dwyer, Jeannette Rodriguez Gonzalez, John Schloen, David M Mendelowitz, Kathryn J Schunke, Jhansi Dyavanapalli, Matthew W. Kay, Carla Rocha

Publikováno v: Circulation Research. 125

There is a distinctive cardiac autonomic imbalance in HF consisting of increased sympathetic activity and decreased parasympathetic tone. Recent work has indicated that activation of paraventricular nucleus (PVN) oxytocin neurons increases co-release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb6da0774ae4dfe446b1961259cd78b7
https://doi.org/10.1161/res.125.suppl_1.307

Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart

Autor: Ralph V. Shohet, Chrisy Mafnas, Allison L Williams, Cynthia D. Anderson, David R Veal, Chad B. Walton, Kathryn J Schunke

Publikováno v: Cardiovasc Res

Aims Hypoxia-inducible factor-1 alpha (HIF-1α) is a key transcription factor responsible for the induction of genes that facilitate adaptation to hypoxia. To study HIF-1 signalling in the heart, we developed a mouse model in which an oxygen-stable f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5328b5db997e6af96bf3d50a99b1e5
https://europepmc.org/articles/PMC6587917/