Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Kathryn J. Schunke"'
Autor:
Emily C. Cheung, Anna Nilsson, Ian Venter, Grant Kowalik, Caitlin Ribeiro, Jeannette Rodriguez, Kiralee Kuraoka, Rebekah Russo, Joan B. Escobar, Bridget R. Alber, David Mendelowitz, Matthew W. Kay, Kathryn J. Schunke
Publikováno v:
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024)
Abstract Pediatric obstructive sleep apnea poses a significant health risk, with potential long‐term consequences on cardiovascular health. This study explores the dichotomous nature of neonatal cardiac response to chronic intermittent hypoxia (CIH
Externí odkaz:
https://doaj.org/article/54d0a5bb49b544ce8476df7b0bb09d9c
Autor:
Jeannette Rodriguez, Joan B. Escobar, Emily C. Cheung, Grant Kowalik, Rebekah Russo, Jhansi Dyavanapalli, Bridget R. Alber, Grey Harral, Aman Gill, Makeda Melkie, Vivek Jain, Kathryn J. Schunke, David Mendelowitz, Matthew W. Kay
Publikováno v:
Hypertension. 80:882-894
Background: Obstructive sleep apnea is a prevalent and poorly treated cardiovascular disease that leads to hypertension and autonomic imbalance. Recent studies that restore cardiac parasympathetic tone using selective activation of hypothalamic oxyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a36feff9c196535e6877cb1291cf2237
https://doi.org/10.1161/hypertensionaha.122.20149
https://doi.org/10.1161/hypertensionaha.122.20149
Autor:
Kathryn J. Schunke, PhD, Lauren M. Rosati, BS, Marianna Zahurak, MS, Joseph M. Herman, MD, MSc, Amol K. Narang, MD, Irina Usach, Alison P. Klein, MHS, PhD, Charles J. Yeo, MD, Larry T. Korman, BSN, Ralph H. Hruban, MD, John L. Cameron, MD, Daniel A. Laheru, MD, Ross A. Abrams, MD
Publikováno v:
Advances in Radiation Oncology, Vol 3, Iss 1, Pp 42-51 (2018)
Purpose: The purpose of this study was to report toxicity and long-term survival outcomes of 2 prospective trials evaluating mitomycin C (MMC) with 5-fluorouracil–based adjuvant chemoradiation in resected periampullary adenocarcinoma. Methods and m
Externí odkaz:
https://doaj.org/article/70f9f35e04b1417eaac32619b7d7d0c1
Autor:
John Schloen, Joan B. Escobar, Christopher F. Spurney, Olga Dergacheva, Xin Wang, Kyung-Min Lee, Kathryn J Schunke, Lisete Compagno Michelini, Whitney Wolaver, Jhansi Dyavanapalli, Carla Rocha dos Santos, Jeannette Rodriguez, Mary Kate Dwyer, David Mendelowitz, Matthew W. Kay
Publikováno v:
JACC: Basic to Translational Science
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Visual Abstract
Highlights • Hypothalamic OXT neurons were chronically activated using a chemogenetic approach in an animal model of HF. • Synaptic release of OXT onto parasympathetic autonomic targets was reduced in animals with HF but rest
Highlights • Hypothalamic OXT neurons were chronically activated using a chemogenetic approach in an animal model of HF. • Synaptic release of OXT onto parasympathetic autonomic targets was reduced in animals with HF but rest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26189fd760c30830ef72f5892b159145
http://europepmc.org/articles/PMC7251188
http://europepmc.org/articles/PMC7251188
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9523, p 9523 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 9523, p 9523 (2021)
Pediatric obstructive sleep apnea has significant negative effects on health and behavior in childhood including depression, failure to thrive, neurocognitive impairment, and behavioral issues. It is strongly associated with an increased risk for chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c25856ab91f8ee3b29282e40b246f82
https://pubmed.ncbi.nlm.nih.gov/34502428
https://pubmed.ncbi.nlm.nih.gov/34502428
Autor:
Abigail Avelar, Ralph V. Shohet, Kathryn J Schunke, Allison L Williams, Vedbar S. Khadka, Mingxin Tang, Mark Menor
Publikováno v:
Physiological Genomics. 50:479-494
Alternative splicing of RNA is an underexplored area of transcriptional response. We expect that early changes in alternatively spliced genes may be important for responses to cardiac injury. Hypoxia inducible factor 1 (HIF1) is a key transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95f2ed6189fae853f53ef7c41f6678e
https://doi.org/10.1152/physiolgenomics.00130.2017
https://doi.org/10.1152/physiolgenomics.00130.2017
Autor:
Larry T. Korman, Marianna Zahurak, Amol Narang, Ralph H. Hruban, Ross A. Abrams, Irina Usach, Lauren M. Rosati, Daniel A. Laheru, Kathryn J Schunke, Charles J. Yeo, John L. Cameron, Joseph M. Herman, Alison P. Klein
Publikováno v:
Advances in Radiation Oncology, Vol 3, Iss 1, Pp 42-51 (2018)
Advances in Radiation Oncology
Advances in Radiation Oncology
Purpose: The purpose of this study was to report toxicity and long-term survival outcomes of 2 prospective trials evaluating mitomycin C (MMC) with 5-fluorouracil–based adjuvant chemoradiation in resected periampullary adenocarcinoma. Methods and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6718a6bad336e4df3e2e12d54f6ca843
http://www.sciencedirect.com/science/article/pii/S2452109417301136
http://www.sciencedirect.com/science/article/pii/S2452109417301136
Autor:
Mary Kate Dwyer, Jeannette Rodriguez Gonzalez, John Schloen, David M Mendelowitz, Kathryn J Schunke, Jhansi Dyavanapalli, Matthew W. Kay, Carla Rocha
Publikováno v:
Circulation Research. 125
There is a distinctive cardiac autonomic imbalance in HF consisting of increased sympathetic activity and decreased parasympathetic tone. Recent work has indicated that activation of paraventricular nucleus (PVN) oxytocin neurons increases co-release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6da0774ae4dfe446b1961259cd78b7
https://doi.org/10.1161/res.125.suppl_1.307
https://doi.org/10.1161/res.125.suppl_1.307
Abstract 373: Regulation of Hypoxia by Chromatin Reader Protein Kinase C Binding Protein 1 (PRKCBP1)
Autor:
Kathryn J Schunke, Ralph V. Shohet
Publikováno v:
Circulation Research. 125
PRKCBP1 (also known as RACK7 and Zmynd8) is a polyvalent chromatin reader known to cooperatively bind acetylated and methylated nucleosomes. Recently it has been shown to regulate transcription and cancer progression by coordinating histone methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33b965bfb0d5d7e80e372a5a7111bb9c
https://doi.org/10.1161/res.125.suppl_1.373
https://doi.org/10.1161/res.125.suppl_1.373
Autor:
Ralph V. Shohet, Chrisy Mafnas, Allison L Williams, Cynthia D. Anderson, David R Veal, Chad B. Walton, Kathryn J Schunke
Publikováno v:
Cardiovasc Res
Aims Hypoxia-inducible factor-1 alpha (HIF-1α) is a key transcription factor responsible for the induction of genes that facilitate adaptation to hypoxia. To study HIF-1 signalling in the heart, we developed a mouse model in which an oxygen-stable f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5328b5db997e6af96bf3d50a99b1e5
https://europepmc.org/articles/PMC6587917/
https://europepmc.org/articles/PMC6587917/
