Výsledky vyhledávání - "Kathryn J. MacLeod"

Photoaffinity Labeling of Wild-type and Mutant Forms of the Yeast V-ATPase A Subunit by 2-Azido-[32P]ADP

Autor: Michael Forgac, Elena Vasilyeva, Keith D. Merdek, Pia D. Vogel, Kathryn J. MacLeod

Publikováno v: Journal of Biological Chemistry. 274:32869-32874

Molecular modeling studies have previously suggested the possible presence of four aromatic residues (Phe(452), Tyr(532), Tyr(535), and Phe(538)) near the adenine binding pocket of the catalytic site on the yeast V-ATPase A subunit (MacLeod, K. J., V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155a03b9ac60a5f4495175255a375c50
https://doi.org/10.1074/jbc.274.46.32869

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SA-4-1BBL as the immunomodulatory component of a HPV-16 E7 protein based vaccine shows robust therapeutic efficacy in a mouse cervical cancer model

Autor: Haval Shirwan, Kathryn J. MacLeod, Rich-Henry Schabowsky, Abhishek K. Srivastava, Rajesh K. Sharma, Esma S. Yolcu, Shravan Madireddi

Cervical cancer is the leading cause of cancer-related deaths among women worldwide. Current prophylactic vaccines based on HPV (Human papillomavirus) late gene protein L1 are ineffective in therapeutic settings. Therefore, there is an acute need for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f715cb4a844ed30c779c9096f83c67
https://europepmc.org/articles/PMC2921468/

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4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines

Autor: Kathryn J. MacLeod, Shravan Madireddi, Hong Zhao, Zhenping Zhong, Robert W. Miller, Abhishek K. Srivastava, Esma S. Yolcu, Rich-Henry Schabowsky, Haval Shirwan, Rajesh K. Sharma, Kutlu G. Elpek

Publikováno v: Cancer research. 70(10)

Therapeutic subunit vaccines based on tumor-associated antigens (TAA) represent an attractive approach for the treatment of cancer. However, poor immunogenicity of TAAs requires potent adjuvants for therapeutic efficacy. We recently proposed the tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd3df76c7d4bd319d1a980eb71eab85
https://pubmed.ncbi.nlm.nih.gov/20406989

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A novel form of 4-1BBL has better immunomodulatory activity than an agonistic anti-4-1BB Ab without Ab-associated severe toxicity

Autor: Laura Bandura-Morgan, Rich-Henry Schabowsky, Kutlu G. Elpek, Kathryn J. MacLeod, Robert J. Miller, Rajesh K. Sharma, Robert S. Mittler, Haval Shirwan, Shravan Madireddi, Esma S. Yolcu

Publikováno v: Vaccine. 28(2)

Agonistic Abs to select costimulatory members of CD28 and TNFR family have shown efficacy in various preclinical cancer immunotherapeutic settings. However, the use of agonistic Abs is often associated with severe toxicity due to non-specific activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f2f4580906c4417d5d0ab92bed91c7
https://pubmed.ncbi.nlm.nih.gov/19836479

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Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms

Autor: Kathryn J. MacLeod, Douglas A. Gage, Kyunghye Ahn, Rhonda D. Husain

Publikováno v: The Journal of biological chemistry. 277(48)

To investigate the phosphorylation of human endothelin-converting enzyme-1 (hECE-1) and identify potential residues involved, both in vivo and in vitro phosphorylation labeling assays of hECE-1 isoforms were performed in combination with site-directe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0718cc3acc2579a2b723d204e2c2c0
https://pubmed.ncbi.nlm.nih.gov/12244060

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Conserved cysteine and tryptophan residues of the endothelin-converting enzyme-1 CXAW motif are critical for protein maturation and enzyme activity

Autor: Jeffrey David Scholten, Kathryn J. MacLeod, Robert S. Fuller, Kyunghye Ahn

Publikováno v: The Journal of biological chemistry. 276(33)

The neprilysin (NEP)/endothelin-converting enzyme (ECE) family of metalloproteases contains a highly conserved carboxyl-terminal tetrapeptide sequence, CXAW, where “C” is cysteine, “X” is a polar amino acid, “A” is an aliphatic residue, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ceee25f5c45623e8bc2024a8ce6c7d0
https://pubmed.ncbi.nlm.nih.gov/11397811

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Cysteine scanning mutagenesis of the noncatalytic nucleotide binding site of the yeast V-ATPase

Autor: Elena Vasilyeva, Michael Forgac, James D. Baleja, Kathryn J. MacLeod, Qing Liu

Publikováno v: The Journal of biological chemistry. 275(1)

To investigate residues involved in the formation of the noncatalytic nucleotide binding sites of the vacuolar proton-translocating adenosine triphosphatase (V-ATPase), cysteine scanning mutagenesis of the VMA2 gene that encodes the B subunit in yeas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc5df2afb650d1720404755e321b370
https://pubmed.ncbi.nlm.nih.gov/10617613

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