Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kathryn J Wicht"'
Autor:
Jennifer L Small-Saunders, Laura M Hagenah, Kathryn J Wicht, Satish K Dhingra, Ioanna Deni, Jonathan Kim, Jeremie Vendome, Eva Gil-Iturbe, Paul D Roepe, Monica Mehta, Filippo Mancia, Matthias Quick, Margaret J Eppstein, David A Fidock
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010278 (2022)
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial combinations. Dihydroartemisinin + piperaquine (PPQ) treatment failure rate
Externí odkaz:
https://doaj.org/article/c0f2898adda746c4b1fca32595599be4
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The biomineral haemozoin, or its synthetic analogue β-haematin (βH), has been the focus of several target-based screens for activity against Plasmodium falciparum parasites. Together with the known βH crystal structure, the availability o
Externí odkaz:
https://doaj.org/article/0e9d9577f75f4ad3b7611cf98b1a8ed3
Autor:
Dorjbal Dorjsuren, Richard T. Eastman, Kathryn J. Wicht, Daniel Jansen, Daniel C. Talley, Benjamin A. Sigmon, Alexey V. Zakharov, Norma Roncal, Andrew T. Girvin, Yevgeniya Antonova-Koch, Paul M. Will, Pranav Shah, Hongmao Sun, Carleen Klumpp-Thomas, Sachel Mok, Tomas Yeo, Stephan Meister, Juan Jose Marugan, Leila S. Ross, Xin Xu, David J. Maloney, Ajit Jadhav, Bryan T. Mott, Richard J. Sciotti, Elizabeth A. Winzeler, Norman C. Waters, Robert F. Campbell, Wenwei Huang, Anton Simeonov, David A. Fidock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The spread of Plasmodium falciparum parasites resistant to most first-line antimalarials creates an imperative to enrich the drug discovery pipeline, preferably with curative compounds that can also act prophylactically. We report a phenotyp
Externí odkaz:
https://doaj.org/article/3166e3dd3b5945e88b4f3c4eb22c8065
Autor:
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J. Wicht, Lubbe Wiesner, Timothy J. Egan, Kelly Chibale
Publikováno v:
ACS Infectious Diseases. 9:653-667
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a808c9aa7fae607b836d3485b45e3752
https://doi.org/10.1021/acsinfecdis.2c00592
https://doi.org/10.1021/acsinfecdis.2c00592
Autor:
Leila S. Ross, Satish K. Dhingra, Sachel Mok, Tomas Yeo, Kathryn J. Wicht, Krittikorn Kümpornsin, Shannon Takala-Harrison, Benoit Witkowski, Rick M. Fairhurst, Frederic Ariey, Didier Menard, David A. Fidock
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Increasing resistance of Plasmodium falciparum strains to piperaquine (PPQ) in Southeast Asia is of concern and resistance mechanisms are incompletely understood. Here, Ross et al. show that mutations in the P. falciparum chloroquine resistance trans
Externí odkaz:
https://doaj.org/article/9e15ba8777674417b0e16955209c6ccc
The biomineral haemozoin, or its synthetic analogue β-haematin (βH), has been the focus of several target-based screens for activity against Plasmodium falciparum parasites. Together with the known βH crystal structure, the availability of this sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0594c5785a0b8324607fe36eb5745f05
https://doi.org/10.21203/rs.3.rs-2329483/v1
https://doi.org/10.21203/rs.3.rs-2329483/v1
Autor:
Rebecca D. Sandlin, Kim Y. Fong, Kathryn J. Wicht, Holly M. Carrell, Timothy J. Egan, David W. Wright
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 4, Iss 3, Pp 316-325 (2014)
The emergence of drug resistant strains of Plasmodium spp. creates a critical need for the development of novel antimalarials. Formation of hemozoin, a crystalline heme detoxification process vital to parasite survival serves as an important drug tar
Externí odkaz:
https://doaj.org/article/5687d1b14efc4616a5dcb0fd0385e968
Publikováno v:
The Journal of infectious diseases. 226(11)
Background Additional therapeutic strategies could benefit efforts to reverse the recent increase in malaria cases in sub-Saharan Africa, which mostly affects young children. A primary candidate is dihydroartemisinin + piperaquine (DHA + PPQ), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35adebe4a4dde4dacddcc7cba4728dd0
https://pubmed.ncbi.nlm.nih.gov/36082431
https://pubmed.ncbi.nlm.nih.gov/36082431
Autor:
Theresa L. Coetzer, Lizette L. Koekemoer, Elizabeth A. Winzeler, Gregory S. Basarab, Richard T. Eastman, Jean Dam, Gurminder Kaur, André Horatscheck, Sonja B Lauterbach, Sabine Ottilie, Hui Guo, Michael J. Delves, Luisa Nardini, Jacek W. Zawada, Dennis A. Smith, James Duffy, Leslie J. Street, Tanya Paquet, Belinda C. Bezuidenhout, Claire Le Manach, Lyn-Marie Birkholtz, Dorjbal Dorjsuren, Liezl Gibhard, Dalu Mancama, Anton Simeonov, David A. Fidock, Christel Brunschwig, Sachel Mok, Daniel C. Talley, Nelius Venter, Mariëtte van der Watt, Grant A. Boyle, John G Woodland, Sergio Wittlin, Ayesha Aswat, Janette Reader, Nina Lawrence, Dale Taylor, Mathew Njoroge, Kelly Chibale, Tomas Yeo, Anjo Theron, Lutete Peguy Khonde, Erica Erlank, Thomas W. von Geldern, Kathryn J. Wicht
Publikováno v:
Journal of Medicinal Chemistry. 64:2291-2309
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748b270a5ec97aeb6e2aead9a27947b0
https://doi.org/10.1021/acs.jmedchem.1c00034
https://doi.org/10.1021/acs.jmedchem.1c00034
Autor:
Jennifer L. Small-Saunders, Laura M. Hagenah, Kathryn J. Wicht, Satish K. Dhingra, Ioanna Deni, Jonathan Kim, Jeremie Vendome, Eva Gil-Iturbe, Paul D. Roepe, Monica Mehta, Filippo Mancia, Matthias Quick, Margaret J. Eppstein, David A. Fidock
Publikováno v:
PLoS pathogens. 18(2)
Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial combinations. Dihydroartemisinin + piperaquine (PPQ) treatment failure rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07caf39901cff43e8b931019593a7b2
https://pubmed.ncbi.nlm.nih.gov/35130315
https://pubmed.ncbi.nlm.nih.gov/35130315