Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Kathryn J, Moore"'
Autor:
Liming Yu, Lin Xu, Haiyan Chu, Jun Peng, Anastasia Sacharidou, Hsi-hsien Hsieh, Ada Weinstock, Sohaib Khan, Liqian Ma, José Gabriel Barcia Durán, Jeffrey McDonald, Erik R. Nelson, Sunghee Park, Donald P. McDonnell, Kathryn J. Moore, Lily Jun-shen Huang, Edward A. Fisher, Chieko Mineo, Linzhang Huang, Philip W. Shaul
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates vascular inflammation is poorly understood. Here we show in male mice that hypercho
Externí odkaz:
https://doaj.org/article/acdb55d979ff40c6a879b2daab171d43
Autor:
Coen van Solingen, Scott R. Oldebeken, Alessandro G. Salerno, Amarylis C. B. A. Wanschel, Kathryn J. Moore
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Investigations into the regulatory mechanisms controlling cholesterol homeostasis have proven fruitful in identifying low-density lipoprotein (LDL)-lowering therapies to reduce the risk of atherosclerotic cardiovascular disease. A major advance was t
Externí odkaz:
https://doaj.org/article/d7a3d43ee4e840f0bee2edb841757972
Autor:
Alessandro G. Salerno, Coen van Solingen, Elena Scotti, Amarylis C. B. A. Wanschel, Milessa S. Afonso, Scott R. Oldebeken, Westley Spiro, Peter Tontonoz, Katey J. Rayner, Kathryn J. Moore
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
MicroRNAs (miRNA) have emerged as important post-transcriptional regulators of metabolic pathways that contribute to cellular and systemic lipoprotein homeostasis. Here, we identify two conserved miRNAs, miR-224, and miR-520d, which target gene netwo
Externí odkaz:
https://doaj.org/article/dd888e03050d4c62a7d61d2593abde3f
Autor:
Emer E. Hackett, Hugo Charles-Messance, Seónadh M. O’Leary, Laura E. Gleeson, Natalia Muñoz-Wolf, Sarah Case, Anna Wedderburn, Daniel G.W. Johnston, Michelle A. Williams, Alicia Smyth, Mireille Ouimet, Kathryn J. Moore, Ed C. Lavelle, Sinéad C. Corr, Stephen V. Gordon, Joseph Keane, Frederick J. Sheedy
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 124-136.e4 (2020)
Summary: Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we observe repression of
Externí odkaz:
https://doaj.org/article/940d7725a10c42f3aa2a7e0bce32ab6d
Autor:
Tarik Hadi, Ludovic Boytard, Michele Silvestro, Dornazsadat Alebrahim, Samson Jacob, Jordyn Feinstein, Krista Barone, Wes Spiro, Susan Hutchison, Russell Simon, Debra Rateri, Florence Pinet, David Fenyo, Mark Adelman, Kathryn J. Moore, Holger K. Eltzschig, Alan Daugherty, Bhama Ramkhelawon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix degradation. Here Hadi et al. identify a netrin-1/neogenin-based crosstalk between macrophages and vascular smooth muscle cells (VSMCs), leading to the secretion of
Externí odkaz:
https://doaj.org/article/6a80aa6aa5a6430686da689e4970e306
Autor:
Daniel A. Giles, Bhama Ramkhelawon, Elizabeth M. Donelan, Traci E. Stankiewicz, Susan B. Hutchison, Rajib Mukherjee, Monica Cappelletti, Rebekah Karns, Christopher L. Karp, Kathryn J. Moore, Senad Divanovic
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1121-1130 (2016)
Objectives: Obesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of death worldwide. Although mouse models have provided important insights into the immunopathogenesis of
Externí odkaz:
https://doaj.org/article/3a694425b8b14094874bf227efada484
Publikováno v:
J Mol Cell Cardiol
The field of cardio-oncology has emerged in response to the increased risk of cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a more complicated CVD-cancer relationship, wherein development of CVD, either prior t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5cd0f05bf760d2f22e2c70c7aa70e5
https://hdl.handle.net/11370/1b8ee702-fc01-41ff-b1f6-6d334b820dbe
https://hdl.handle.net/11370/1b8ee702-fc01-41ff-b1f6-6d334b820dbe
Autor:
John S. Mattick, Paulo P. Amaral, Piero Carninci, Susan Carpenter, Howard Y. Chang, Ling-Ling Chen, Runsheng Chen, Caroline Dean, Marcel E. Dinger, Katherine A. Fitzgerald, Thomas R. Gingeras, Mitchell Guttman, Tetsuro Hirose, Maite Huarte, Rory Johnson, Chandrasekhar Kanduri, Philipp Kapranov, Jeanne B. Lawrence, Jeannie T. Lee, Joshua T. Mendell, Timothy R. Mercer, Kathryn J. Moore, Shinichi Nakagawa, John L. Rinn, David L. Spector, Igor Ulitsky, Yue Wan, Jeremy E. Wilusz, Mian Wu
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II and Pol III transcribed RNAs, and RNAs from processed introns. The various fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0d653a08b1ff966e3a25a1dcce17c7
Autor:
Coen, van Solingen, Yannick, Cyr, Kaitlyn R, Scacalossi, Maren, de Vries, Tessa J, Barrett, Annika, de Jong, Morgane, Gourvest, Tracy, Zhang, Daniel, Peled, Raadhika, Kher, MacIntosh, Cornwell, Michael A, Gildea, Emily J, Brown, Stephanie, Fanucchi, Musa M, Mhlanga, Jeffrey S, Berger, Meike, Dittmann, Kathryn J, Moore
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(37)
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of gene expression, yet their contribution to immune regulation in humans remains poorly understood. Here, we report that the primate-specific lncRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38054980a02045ece86cbf8fcd942514
https://pubmed.ncbi.nlm.nih.gov/36001732
https://pubmed.ncbi.nlm.nih.gov/36001732
Autor:
Martin Schlegel, Lianne C Shanley, Narendra Verma, Daniel Peled, Jenny Y Yoo, Coen van Solingen, Elisabetta Mueller, Yannick Cyr, Luce Perie, Kathryn J. Moore, Milessa Silva Afonso, Ann Marie Schmidt, Monika Sharma, Emma M Corr
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective:Recent studies have identified key transcriptional regulators of brown adipose tissue (BAT) differentiation and function, but posttranscriptional control of this network by microRNAs remains incompletely understood. MiR-33 critically regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8464b38374620bfe3925977efd66b64
https://doi.org/10.1161/atvbaha.120.315798
https://doi.org/10.1161/atvbaha.120.315798