Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Kathryn J, Else"'
Autor:
Alexander R. Bennett, Iris Mair, Andrew Muir, Hannah Smith, Larisa Logunova, Andrew Wolfenden, Jonathan Fenn, Ann E. Lowe, Janette E. Bradley, Kathryn J. Else, David J. Thornton
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Mucin protein glycosylation is important in determining biological properties of mucus gels, which form protective barriers at mucosal surfaces of the body such as the intestine. Ecological factors including: age, sex, and diet can change mu
Externí odkaz:
https://doaj.org/article/ac89f561e69d45c38002ffb7599e043b
Autor:
Iris Mair, Jonathan Fenn, Andrew Wolfenden, Ann E Lowe, Alex Bennett, Andrew Muir, Jacob Thompson, Olive Dieumerci, Larisa Logunova, Susanne Shultz, Janette E Bradley, Kathryn J Else
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012119 (2024)
Laboratory model organisms have provided a window into how the immune system functions. An increasing body of evidence, however, suggests that the immune responses of naive laboratory animals may differ substantially to those of their wild counterpar
Externí odkaz:
https://doaj.org/article/4e1bbbd0da5f4873a3dc7c3561733d58
Autor:
Pia M. Vornewald, Ruth Forman, Rouan Yao, Naveen Parmar, Håvard T. Lindholm, Lilith S. K. Lee, Mara Martín-Alonso, Kathryn J. Else, Menno J. Oudhoff
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Intestinal epithelial homeostasis is maintained by intrinsic and extrinsic signals. The extrinsic signals include those provided by mesenchymal cell populations that surround intestinal crypts and is further facilitated by the extracellular matrix (E
Externí odkaz:
https://doaj.org/article/5662fcecce6d4c588ab6033c643948ce
Autor:
Frederick A. Partridge, Ruth Forman, Carole J. R. Bataille, Graham M. Wynne, Marina Nick, Angela J. Russell, Kathryn J. Else, David B. Sattelle
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1203-1224 (2020)
Helminths, including cestodes, nematodes and trematodes, are a huge global health burden, infecting hundreds of millions of people. In many cases, existing drugs such as benzimidazoles, diethylcarbamazine, ivermectin and praziquantel are insufficient
Externí odkaz:
https://doaj.org/article/00c5a4befa5e42acba226a9346c95457
Autor:
James D. B. O’Sullivan, Sheena M. Cruickshank, Tobias Starborg, Philip J. Withers, Kathryn J. Else
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract The parasitic nematode Trichuris trichiura is a significant burden on public health in developing countries, and currently available drugs exhibit a poor cure rate. Worms live within a specialised tunnel of host intestinal epithelial cells a
Externí odkaz:
https://doaj.org/article/47ddcf3981df4a43b0d07963c95468f8
Autor:
Ruth Forman, Larisa Logunova, Hannah Smith, Kelly Wemyss, Iris Mair, Louis Boon, Judith E Allen, Werner Muller, Joanne L Pennock, Kathryn J Else
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009768 (2021)
The intestinal nematode parasite Trichuris muris dwells in the caecum and proximal colon driving an acute resolving intestinal inflammation dominated by the presence of macrophages. Notably, these macrophages are characterised by their expression of
Externí odkaz:
https://doaj.org/article/c66c777140c7426f8f87146164ffbd92
Autor:
Ayat Zawawi, Kathryn J. Else
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Parasitic helminths infect over one-fourth of the human population resulting in significant morbidity, and in some cases, death in endemic countries. Despite mass drug administration (MDA) to school-aged children and other control measures, helminth
Externí odkaz:
https://doaj.org/article/ba46bc2e3dcb4e1ca85f5e47a341d989
Autor:
Ayat Zawawi, Ruth Forman, Hannah Smith, Iris Mair, Murtala Jibril, Munirah H Albaqshi, Andrew Brass, Jeremy P Derrick, Kathryn J Else
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008243 (2020)
Trichuris trichiura is a parasite that infects 500 million people worldwide, leading to colitis, growth retardation and Trichuris dysentery syndrome. There are no licensed vaccines available to prevent Trichuris infection and current treatments are o
Externí odkaz:
https://doaj.org/article/b929adeb1cf146ea9d777e373cda187b
Autor:
Frederick A. Partridge, Anwen E. Brown, Steven D. Buckingham, Nicky J. Willis, Graham M. Wynne, Ruth Forman, Kathryn J. Else, Alison A. Morrison, Jacqueline B. Matthews, Angela J. Russell, David A. Lomas, David B. Sattelle
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 8-21 (2018)
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic comp
Externí odkaz:
https://doaj.org/article/c42f40dcf1474713bfa44bf04087ce17
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
How B cells contribute to protective immunity against parasitic nematodes remains unclear, with their importance as accessory cells underexplored. In this study, anti-CD20 monoclonal antibody (α-CD20 mAb)-mediated depletion of B cells from C57BL/6 m
Externí odkaz:
https://doaj.org/article/8b7dce0326c349f194499e33f0985c54