Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Kathryn Haskins"'
Autor:
Janet M. Wenzlau, Orion J. Peterson, Anthony N. Vomund, James E. DiLisio, Anita Hohenstein, Kathryn Haskins, Xiaoxiao Wan
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
There is accumulating evidence that pathogenic T cells in T1D recognize epitopes formed by post-translational modifications of β-cell antigens, including hybrid insulin peptides (HIPs). The ligands for several CD4 T-cell clones derived from the NOD
Externí odkaz:
https://doaj.org/article/84ce55f5581a419585d943e1ba673e26
Publikováno v:
Diagnostics, Vol 13, Iss 17, p 2859 (2023)
Type 1 diabetes (T1D) is a chronic autoimmune disease that attacks the insulin-producing b cells of the pancreatic islets. Autoantibodies to b cell proteins typically appear in the circulation years before disease onset, and serve as the most accurat
Externí odkaz:
https://doaj.org/article/f37c4cfbf24749cab36b288ffc18da7a
Autor:
Janet M. Wenzlau, James E. DiLisio, Gene Barbour, Mylinh Dang, Anita C. Hohenstein, Maki Nakayama, Thomas Delong, Rocky L. Baker, Kathryn Haskins
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Insulin is considered to be a key antigenic target of T cells in Type 1 Diabetes (T1D) and autoimmune diabetes in the NOD mouse with particular focus on the B-chain amino acid sequence B:9-23 as the primary epitope. Our lab previously discovered that
Externí odkaz:
https://doaj.org/article/d76cc12a82c74f1d8df87c2551cce996
Autor:
Timothy A. Wiles, Anita Hohenstein, Laurie G. Landry, Mylinh Dang, Roger Powell, Perrin Guyer, Eddie A. James, Maki Nakayama, Kathryn Haskins, Thomas Delong, Rocky L. Baker
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Hybrid Insulin Peptides (HIPs), which consist of insulin fragments fused to other peptides from β-cell secretory granule proteins, are CD4 T cell autoantigens in type 1 diabetes (T1D). We have studied HIPs and HIP-reactive CD4 T cells extensively in
Externí odkaz:
https://doaj.org/article/e186d718d2c24746bca1962867bcb7b6
Autor:
Tobias Neef, Igal Ifergan, Sara Beddow, Pablo Penaloza-MacMaster, Kathryn Haskins, Lonnie D. Shea, Joseph R. Podojil, Stephen D. Miller
Publikováno v:
Cells, Vol 10, Iss 12, p 3445 (2021)
We have shown that PLG nanoparticles loaded with peptide antigen can reduce disease in animal models of autoimmunity and in a phase 1/2a clinical trial in celiac patients. Clarifying the mechanisms by which antigen-loaded nanoparticles establish tole
Externí odkaz:
https://doaj.org/article/4e8e07533efb4ca1b02b3300c04e13ab
CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes
Autor:
Adam M. Sandor, Robin S. Lindsay, Nathan Dyjack, Jennifer C. Whitesell, Cydney Rios, Brenda J. Bradley, Kathryn Haskins, David V. Serreze, Aron M. Geurts, Yi-Guang Chen, Max A. Seibold, Jordan Jacobelli, Rachel S. Friedman
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease that affects more than 19 million people with incidence increasing rapidly worldwide. For T cells to effectively drive T1D, they must first traffic to the islets and extravasate through th
Externí odkaz:
https://doaj.org/article/84f626d760c74ffda3d49e544096b774
Autor:
James E. DiLisio, Kathryn Haskins
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 240 (2021)
Autoreactive T cells are thought to orchestrate the onset and progression of autoimmune diabetes. Key cognate antigens of these diabetogenic T cells include hybrid insulin peptides, formed by the fusion of insulin fragments to cleavage products of ot
Externí odkaz:
https://doaj.org/article/659c437ef98140c88216451dbf13991c
Autor:
Braxton L. Jamison, James E. DiLisio, K. Scott Beard, Tobias Neef, Brenda Bradley, Jessica Goodman, Ronald G. Gill, Stephen D. Miller, Rocky L. Baker, Kathryn Haskins
Publikováno v:
Diabetes
The induction of antigen (Ag)-specific tolerance and replacement of islet β-cells are major ongoing goals for the treatment of type 1 diabetes (T1D). Our group previously showed that a hybrid insulin peptide (2.5HIP) is a critical autoantigen for di
Autor:
Samantha A. Crawford, Timothy A. Wiles, Janet M. Wenzlau, Roger L. Powell, Gene Barbour, Mylinh Dang, Jason Groegler, Jessie M. Barra, KaLia S. Burnette, Anita C. Hohenstein, Rocky L. Baker, Hubert M. Tse, Kathryn Haskins, Thomas Delong
Publikováno v:
Diabetes. 71(12)
Hybrid insulin peptides (HIPs) form in pancreatic beta-cells through the formation of peptide bonds between proinsulin fragments and other peptides. HIPs have been identified in pancreatic islets by mass spectrometry and are targeted by CD4 T cells i
Autor:
I-Ting Chow, Kathryn Haskins, William W. Kwok, Eddie A. James, Thomas Delong, Cate Speake, David Arribas-Layton, Mylinh Dang, Perrin Guyer, Rocky L. Baker, Carla J. Greenbaum
Publikováno v:
Diabetes
T cells isolated from the pancreatic infiltrates of nonobese diabetic mice have been shown to recognize epitopes formed by the covalent cross-linking of proinsulin and secretory granule peptides. Formation of such hybrid insulin peptides (HIPs) was c