Výsledky vyhledávání - "Kathryn H. Driesbaugh"

Akademický článek

Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis.

Autor: Raymond J Peroutka, Marguerite S Buzza, Subhradip Mukhopadhyay, Tierra A Johnson, Kathryn H Driesbaugh, Toni M Antalis

Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0234407 (2020)

Testisin (encoded by PRSS21) is a membrane anchored serine protease, which is tethered to the cell surface via a glycosylphosphatidylinositol (GPI)-anchor. While testisin is found in abundance in spermatozoa, it is also expressed in microvascular end

Externí odkaz: https://doaj.org/article/3a375470eabf47728b60b4c917e2d360

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Altered Responsiveness to TGFβ and BMP and Increased CD45+ Cell Presence in Mitral Valves Are Unique Features of Ischemic Mitral Regurgitation

Autor: Michael S. Sacks, Chiara Camillo, Robert C. Gorman, Takayuki Kawashima, Isaac George, Estibaliz Castillero, Giovanni Ferrari, Kathryn H. Driesbaugh, Robert J. Levy, Samuel Keeney, Daniel P. Howsmon, Bruno V. Rego, Joseph H. Gorman, Yingfei Xue

Publikováno v: Arterioscler Thromb Vasc Biol

Objective: Ischemic mitral regurgitation (IMR) often develops after an ischemic event, which results in distortion of the valvulo-ventricular complex and incomplete mitral valve (MV) leaflet coaptation. After left ventricular ischemic events, only so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9669ef79acb2e2c2c0c07fe057373c
https://doi.org/10.1161/atvbaha.121.316111

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Testisin/Prss21 deficiency causes increased vascular permeability and a hemorrhagic phenotype during luteal angiogenesis

Autor: Marguerite S. Buzza, Kathryn H. Driesbaugh, Subhradip Mukhopadhyay, Toni M. Antalis, Tierra A. Johnson, Raymond J. Peroutka

Publikováno v: PLoS ONE, Vol 15, Iss 6, p e0234407 (2020)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae648da794997d665cf2311a1ae7f09
https://doaj.org/article/3a375470eabf47728b60b4c917e2d360

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Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis

Autor: David T Guerrero, Ivan S. Alferiev, Michael Chorny, Alex Mas Monteys, J B Foster, Chandrasekaran Nagaswami, N G Minutolo, Robert J. Levy, Ilia Fishbein, Kathryn H. Driesbaugh

Publikováno v: Gene therapy

In-stent restenosis remains an important clinical problem in the era of drug eluting stents. Development of clinical gene therapy protocols for the prevention and treatment of in-stent restenosis is hampered by the lack of adequate local delivery sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0326922b5f58c0f97f225841808b3d
http://europepmc.org/articles/PMC5709213

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Serotonin Receptor 2B Signaling with Interstitial Cell Activation and Leaflet Remodeling in Degenerative Mitral Regurgitation

Autor: Emanuela Branchetti, Kimberly Glass, Salma Ayoub, Kathryn H. Driesbaugh, Samuel Keeney, Nancy Rioux, Mark A. Oyama, John Quackenbush, Robert J. Levy, Giovanni Ferrari, Juan B. Grau, Michael S. Sacks

Aims Mitral valve interstitial cells (MVIC) play an important role in the pathogenesis of degenerative mitral regurgitation (MR) due to mitral valve prolapse (MVP). Numerous clinical studies have observed serotonin (5HT) dysregulation in cardiac valv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40af3439acde481ac23871a7cae2938d
https://europepmc.org/articles/PMC5856457/

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Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden

Autor: Kathryn H. Driesbaugh, Toni M. Antalis, Stephen H. Leppla, Erik W. Martin, Marguerite S. Buzza, Shihui Liu, Yolanda M. Fortenberry

Publikováno v: Oncotarget

The membrane-anchored serine proteases are a unique group of trypsin-like serine proteases that are tethered to the cell surface via transmembrane domains or glycosyl-phosphatidylinositol-anchors. Overexpressed in tumors, with pro-tumorigenic propert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65870e8e84336758c1d5c8417384fde0
https://doi.org/10.18632/oncotarget.5214

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Proteolytic Activation of the Protease-activated Receptor (PAR)-2 by the Glycosylphosphatidylinositol-anchored Serine Protease Testisin

Autor: Joseph P. Y. Kao, Marguerite S. Buzza, Kathryn H. Driesbaugh, Erik W. Martin, Toni M. Antalis, Gregory D. Conway

Publikováno v: Journal of Biological Chemistry. 290:3529-3541

Protease-activated receptors (PARs) are a family of seven-transmembrane, G-protein-coupled receptors that are activated by multiple serine proteases through specific N-terminal proteolytic cleavage and the unmasking of a tethered ligand. The majority

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65708e0c845e4142f94a416d36e31231
https://doi.org/10.1074/jbc.m114.628560

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Regulation of valve interstitial cell homeostasis by mechanical deformation: implications for heart valve disease and surgical repair

Autor: Kathryn H. Driesbaugh, Robert C. Gorman, Connor T. Hughes, Michael S. Sacks, Wanda Anselmo, Giovanni Ferrari, Chung-Hao Lee, Salma Ayoub, Joseph H. Gorman

Mechanical stress is one of the major aetiological factors underlying soft-tissue remodelling, especially for the mitral valve (MV). It has been hypothesized that altered MV tissue stress states lead to deviations from cellular homeostasis, resulting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f217145705fcecd1e425b5fc51e680
https://europepmc.org/articles/PMC5665836/

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Abstract 247: The Association of the Serotonin Transporter Polymorphism LL-Genotype with Non-Syndromic Mitral Valve Prolapse Requiring Surgery at a Younger Age

Autor: Kathryn H Driesbaugh, Juan B Grau, Eric K Lai, Emanuela Branchetti, Nancy Rioux, Farrah Alkhaleel, Nathan Frick, Robert J Levy, Giovanni Ferrari

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 37

Background: Non-syndromic mitral valve prolapse (MVP) is a highly prevalent heart valve disease that is treated surgically when indicated by clinical deterioration. Serotonin (5HT)-related valvulopathies have been reported; however, 5HT has not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2edb586fd9ec003fdd28bb51f8ef7ee5
https://doi.org/10.1161/atvb.37.suppl_1.247

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SerpinB2 Is Critical to Th2 Immunity against Enteric Nematode Infection

Autor: Aiping Zhao, Sarah Netzel-Arnett, Terez Shea-Donohue, Kathryn H. Driesbaugh, Ian E. Anglin, Luigi Notari, Toni M. Antalis, Rex Sun, Joseph F. Urban, Viktoryia Grinchuk, Kathleen B. Madden, Jennifer A. Bohl, Zhonghan Yang

Publikováno v: The Journal of Immunology. 190:5779-5787

SerpinB2, a member of the serine protease inhibitor family, is expressed by macrophages and is significantly upregulated by inflammation. Recent studies implicated a role for SerpinB2 in the control of Th1 and Th2 immune responses, but the mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c210aeaa49a3e247b9510abbe6b9f876
https://doi.org/10.4049/jimmunol.1200293

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