Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kathryn Gudsnuk"'
Publikováno v:
Genome Res
There are more than 55,000 variable number tandem repeats (VNTRs) in the human genome, notable for both their striking polymorphism and mutability. Despite their role in human evolution and genomic variation, they have yet to be studied collectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b56b5f6f0b88cab5ec49f2a957d9d7
https://doi.org/10.1101/gr.275560.121
https://doi.org/10.1101/gr.275560.121
Paternal stress exposure is known to impact the development of stress-related behaviors in offspring. Previous work has highlighted the importance of sperm mediated factors, such as RNAs, in transmitting the effects of parental stress. However, a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052fa42749a6ecdf69b94f47ce5967a1
https://doi.org/10.1101/2022.03.25.485798
https://doi.org/10.1101/2022.03.25.485798
Autor:
Paul N. Valdmanis, Mark A. Kay, Cynthia V. Bourassa, Kathryn Gudsnuk, Meredith M. Course, Nicolas Dupré, Guy A. Rouleau, Suman Jayadev, Dan Spiegelman, Chang En Yu, Evan E. Eichler, Samuel N. Smukowski, Arvis Sulovari, Debby W. Tsuang, Jay P. Ross, Nitin Desai, Aaron D. Gitler, Julien Couthouis, Kosuke Winston, Patrick A. Dion
Publikováno v:
Am J Hum Genet
Tandem repeats are proposed to contribute to human-specific traits, and more than 40 tandem repeat expansions are known to cause neurological disease. Here, we characterize a human-specific 69 bp variable number tandem repeat (VNTR) in the last intro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d009d0e8114e1d6d9b1e21b77ac17948
https://doi.org/10.1016/j.ajhg.2020.07.004
https://doi.org/10.1016/j.ajhg.2020.07.004
Publikováno v:
Molecular Therapy. Nucleic Acids
Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disrupt the processing of endogenous microRNAs (miRNAs) and lead to toxicity. Here, we sought to underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec62a66c7124acf7d3b9e21156c1aa49
https://doi.org/10.1016/j.omtn.2019.12.007
https://doi.org/10.1016/j.omtn.2019.12.007
Autor:
Meredith M Course, Kathryn Gudsnuk, C Dirk Keene, Thomas D Bird, Suman Jayadev, Paul N Valdmanis
Publikováno v:
Brain
Alzheimer’s disease is the most common neurodegenerative disease, characterized by dementia and premature death. Early-onset familial Alzheimer’s disease is caused in part by pathogenic variants in presenilin 1 (PSEN1) and presenilin 2 (PSEN2), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bba41a0ccd6a8285ab2774df7d652b
https://pubmed.ncbi.nlm.nih.gov/35949106
https://pubmed.ncbi.nlm.nih.gov/35949106
Publikováno v:
Neuromethods ISBN: 9781071623565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c545b414c0f483a7153b2d2b649fb0f
https://doi.org/10.1007/978-1-0716-2357-2_5
https://doi.org/10.1007/978-1-0716-2357-2_5
There are over 55,000 variable number tandem repeats (VNTRs) in the human genome, notable for both their striking polymorphism and mutability. Despite their role in human evolution and genomic variation, they have yet to be studied collectively and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::451e7287b16b55f39c6a1b92e44d86c1
https://doi.org/10.1101/2021.03.25.437092
https://doi.org/10.1101/2021.03.25.437092
Publikováno v:
J Vis Exp
Half of all human transcripts are thought to be regulated by microRNAs. Therefore, quantifying microRNA expression can reveal underlying mechanisms in disease states and provide therapeutic targets and biomarkers. Here, we detail how to accurately qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3895c8195c8e02c06f8309b18fab28bd
https://doi.org/10.3791/59901
https://doi.org/10.3791/59901
Autor:
Kathryn Gudsnuk, Hanjie Zhang, Christina Maher, Jacob D. McDonald, Frances A. Champagne, Zhonghai Yan, Rachel L. Miller
Publikováno v:
Neuroepigenetics. 5:11-18
Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) has been associated with sustained effects on the brain and behavior in offspring. However, the mechanisms have yet to be determined. We hypothesized that prenatal exposure to ambient PAH in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f8bc91032cf5e0ef971228aca15333
https://doi.org/10.1016/j.nepig.2016.02.001
https://doi.org/10.1016/j.nepig.2016.02.001
Autor:
Kathryn Gudsnuk, Frances A. Champagne
Publikováno v:
ILAR Journal. 53:279-288
Animal models of early-life stress and variation in social experience across the lifespan have contributed signifi cantly to our understanding of the environmental regulation of the developing brain. Plasticity in neurobiological pathways regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4328af64d0cb9832476b60c81cd85d4f
https://doi.org/10.1093/ilar.53.3-4.279
https://doi.org/10.1093/ilar.53.3-4.279