Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Kathryn G. Roberts"'
Autor:
Afonso R. M. Almeida, João L. Neto, Ana Cachucho, Mayara Euzébio, Xiangyu Meng, Rathana Kim, Marta B. Fernandes, Beatriz Raposo, Mariana L. Oliveira, Daniel Ribeiro, Rita Fragoso, Priscila P. Zenatti, Tiago Soares, Mafalda R. de Matos, Juliana Ronchi Corrêa, Mafalda Duque, Kathryn G. Roberts, Zhaohui Gu, Chunxu Qu, Clara Pereira, Susan Pyne, Nigel J. Pyne, Vasco M. Barreto, Isabelle Bernard-Pierrot, Emannuelle Clappier, Charles G. Mullighan, Ana R. Grosso, J. Andrés Yunes, João T. Barata
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Interleukin-7 receptor alpha (IL7Ra) is important for lymphoid cell development but its role in leukaemogenesis is not clear. Here, the authors generate a knock-in murine model to show that activating mutations in IL7Ra can initiate precursor B-cell
Externí odkaz:
https://doaj.org/article/83e6d6932423405685472917e2af4d77
Autor:
Yin-Chen Hsu, Chih-Hsiang Yu, Yan-Ming Chen, Kathryn G. Roberts, Yu-Ling Ni, Kai-Hsin Lin, Shiann-Tarng Jou, Meng-Yao Lu, Shu-Huey Chen, Kang-Hsi Wu, Hsiu-Hao Chang, Dong-Tsamn Lin, Shu-Wha Lin, Ze-Shiang Lin, Wei-Tzu Chiu, Chia-Ching Chang, Bing-Ching Ho, Charles G. Mullighan, Sung-Liang Yu, Yung-Li Yang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukaemia (ALL), a high-risk subtype characterised by genomic alterations that activate cytokine receptor and kinase signalling, is associated with inferior outcomes in most childhoo
Externí odkaz:
https://doaj.org/article/7f04befddc3f4e6aa76357fc7ad5066b
Autor:
Thai Hoa Tran, Jonathan V. Nguyen, Adrian Stecula, Jon Akutagawa, Anthony V. Moorman, Benjamin S. Braun, Andrej Sali, Charles G. Mullighan, Neil P. Shah, Yunfeng Dai, Meenakshi Devidas, Kathryn G. Roberts, Catherine C. Smith, Mignon L. Loh
Publikováno v:
Haematologica, Vol 106, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/6b4cc17e613943ff9b4b6ed26ceaa218
Autor:
Ilaria Iacobucci, Kathryn G. Roberts
Publikováno v:
Genes, Vol 12, Iss 5, p 687 (2021)
Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a subgroup of B-cell precursor ALL which by gene expression analysis clusters with Philadelphia-positive ALL although lacking the pathognomonic BCR-ABL1 oncoprotein. Its prevalence inc
Externí odkaz:
https://doaj.org/article/d33eaafa072b41ce97b870b325a4db83
Autor:
Kathryn G. Roberts, Yung-Li Yang, Debbie Payne-Turner, Wenwei Lin, Jacob K. Files, Kirsten Dickerson, Zhaohui Gu, Jack Taunton, Laura J. Janke, Taosheng Chen, Mignon L. Loh, Stephen P. Hunger, Charles G. Mullighan
Publikováno v:
Blood Advances, Vol 1, Iss 20, Pp 1657-1671 (2017)
Abstract: New therapies for Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) patients are urgently needed. The genetic landscape of Ph-like ALL is characterized by a diverse array of kinase-activating alterations (including r
Externí odkaz:
https://doaj.org/article/5dc19ee2c90d4053a50cae2afceaa77b
Autor:
Nitin Jain, Xinyan Lu, Naval Daver, Beenu Thakral, Sa A. Wang, Sergej Konoplev, Keyur Patel, Rashmi Kanagal-Shamanna, Marcus Valentine, Guilin Tang, Naveen Pemmaraju, Jeffrey Jorgensen, Partow Kebriaei, Cesar A. Nunez, William Wierda, Elias Jabbour, Kathryn G. Roberts, Charles G. Mullighan, Hagop Kantarjian, Marina Konopleva
Publikováno v:
Haematologica, Vol 102, Iss 12 (2017)
Externí odkaz:
https://doaj.org/article/26e18557719e4510accaecd44b4d2025
Autor:
Tobias Herold, Stephanie Schneider, Klaus H. Metzeler, Martin Neumann, Luise Hartmann, Kathryn G. Roberts, Nikola P. Konstandin, Philipp A. Greif, Kathrin Bräundl, Bianka Ksienzyk, Natalia Huk, Irene Schneider, Evelyn Zellmeier, Vindi Jurinovic, Ulrich Mansmann, Wolfgang Hiddemann, Charles G. Mullighan, Stefan K. Bohlander, Karsten Spiekermann, Dieter Hoelzer, Monika Brüggemann, Claudia D. Baldus, Martin Dreyling, Nicola Gökbuget
Publikováno v:
Haematologica, Vol 102, Iss 1 (2017)
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic and clinical characterizatio
Externí odkaz:
https://doaj.org/article/84e5a90aec6e4f8595b893229fdb61ba
Autor:
Marketa Zaliova, Anthony V. Moorman, Giovanni Cazzaniga, Martin Stanulla, Richard C. Harvey, Kathryn G. Roberts, Sue L. Heatley, Mignon L. Loh, Marina Konopleva, I-Ming Chen, Olga Zimmermannova, Claire Schwab, Owen Smith, Marie-Joelle Mozziconacci, Christian Chabannon, Myungshin Kim, J. H. Frederik Falkenburg, Alice Norton, Karen Marshall, Oskar A. Haas, Julia Starkova, Jan Stuchly, Stephen P. Hunger, Deborah White, Charles G. Mullighan, Cheryl L. Willman, Jan Stary, Jan Trka, Jan Zuna
Publikováno v:
Haematologica, Vol 101, Iss 9 (2016)
To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias, representing targetable kinase-activating lesions, we analyzed 44 new and published cases of ETV6-ABL1-positive hematologic malignancies [22 cases of acute lymphobl
Externí odkaz:
https://doaj.org/article/dd4b46bdd4834a76b94ef10e18e26193
Autor:
Sarra L. Ryan, John F. Peden, Zoya Kingsbury, Claire J. Schwab, Terena James, Petri Polonen, Martina Mijuskovic, Jenn Becq, Richard Yim, Ruth E. Cranston, Dale J. Hedges, Kathryn G. Roberts, Charles G. Mullighan, Ajay Vora, Lisa J. Russell, Robert Bain, Anthony V. Moorman, David R. Bentley, Christine J. Harrison, Mark T. Ross
Publikováno v:
Leukemia. 37:518-528
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent genetic abnormalities that drive risk-directed treatment strategies. Using current techniques, accurate detection of such aberrations can be challenging, due to the
Autor:
Qingsong Gao, Sarra L Ryan, Ilaria Iacobucci, Pankaj S Ghate, Ruth E Cranston, Claire J Schwab, Abdelrahman H. Elsayed, Lei Shi, Stanley B Pounds, Shaohua Lei, Pradyumna Baviskar, Deqing Pei, Cheng Cheng, Matthew Bashton, Paul B Sinclair, David R Bentley, Mark Ross, Zoya Kingsbury, Terena James, Kathryn G Roberts, Meenakshi Devidas, Yiping Fan, Wenan Chen, Ti-Cheng Chang, Gang Wu, Andrew J. Carroll, Nyla A. Heerema, Virginia Valentine, Marcus B Valentine, Wenjian Yang, Jun J. Yang, Anthony V Moorman, Christine J Harrison, Charles G. Mullighan
Publikováno v:
Blood Journal.
Intrachromosomal amplification of chromosome 21 defines a subtype of high-risk childhood acute lymphoblastic leukemia (iAMP21-ALL) characterized by copy number changes and complex rearrangements of chromosome 21. The genomic basis of iAMP21-ALL and t