Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Kathryn G. Commons"'
Publikováno v:
J Comp Neurol
Fgf8 is expressed transiently during embryogenesis at the midbrain-hindbrain border, an area that gives rise to a variety of neuronal populations including the dorsal raphe nucleus (DR). Using an inducible Fgf8-cre allele we identified the population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96945749f8a529a8e6775f040b6d2939
https://doi.org/10.1002/cne.25071
https://doi.org/10.1002/cne.25071
Autor:
Paul G. Hatini, Kathryn G. Commons
Publikováno v:
European Journal of Neuroscience. 52:4370-4374
Mutations in the SCN1A gene encoding the Nav1.1 sodium channel cause several forms of epilepsy, the most severe is Dravet syndrome (DS). DS patients are at high risk for sudden death and seizures are often triggered by fever or hyperthermia. To impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43aa53b9574d1663a69cfa6bf0cc0984
https://doi.org/10.1111/ejn.14776
https://doi.org/10.1111/ejn.14776
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117601 (2015)
Neuroplasticity in the mesolimbic dopaminergic system is critical for behavioral adaptations associated with opioid reward and addiction. These processes may be influenced by cholinergic transmission arising from the laterodorsal tegmental nucleus (L
Externí odkaz:
https://doaj.org/article/1a900c7de4e54310bc7d4f53f3aa7695
Publikováno v:
Nature Reviews Neuroscience. 20:397-424
Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core set of genes that establish and maintain this neurotransmitter phenotype and distinguish these neurons from other brain cells. Beyond a shared 5-HTergic phenotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6866bbcc0cf7f005919df17ab8b21f
https://doi.org/10.1038/s41583-019-0151-3
https://doi.org/10.1038/s41583-019-0151-3
Autor:
Kathryn G. Commons, Sofia E. Linnros
Publikováno v:
ACS Chem Neurosci
Many conventional antidepressants can quickly raise the levels of extracellular serotonin, yet their positive effects on mood ensues only weeks later. This delay in efficacy is a clinical problem that has proven difficult to overcome. Early investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a6266bceab03f4ba5e3546eafc8fd7
https://doi.org/10.1021/acschemneuro.8b00698
https://doi.org/10.1021/acschemneuro.8b00698
UNRAVELING THE ARCHITECTURE OF THE DORSAL RAPHE SYNAPTIC NEUROPIL USING HIGH-RESOLUTION NEUROANATOMY
Publikováno v:
Frontiers in Neural Circuits, Vol 8 (2014)
The dorsal raphe nucleus (DRN), representing the main source of brain’s serotonin, is implicated in the pathophysiology and therapeutics of several mental disorders that can be debilitating and life-long including depression, anxiety and autism. Th
Externí odkaz:
https://doaj.org/article/b84e8b34ffe9415fafc13ed00530aafb
Autor:
Paul G, Hatini, Kathryn G, Commons
Publikováno v:
Eur J Neurosci
Mutations in the SCN1A gene encoding the Nav1.1 sodium channel cause several forms of epilepsy, the most severe is Dravet syndrome (DS). DS patients are at high risk for sudden death and seizures are often triggered by fever or hyperthermia. To impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f39ad3d21a9621c88139502f47f6eb8
https://pubmed.ncbi.nlm.nih.gov/32394465
https://pubmed.ncbi.nlm.nih.gov/32394465
Autor:
Kathryn G. Commons
Serotonin neurotransmission is associated with emotional brain function and seems particularly relevant to changes in emotion and behavior over time. Serotonin neurons are diverse in many cellular characteristics, supporting functional diversity. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22c6bb4190973abd1be7227199e6f4c7
https://doi.org/10.1016/b978-0-444-64125-0.00003-7
https://doi.org/10.1016/b978-0-444-64125-0.00003-7
Publikováno v:
Neuropharmacology. 141:139-147
Serotonin (5-HT) neurons are strongly implicated in mood disorders such as depression and are importantly regulated by feedback inhibition mediated by 5-HT(1A) receptors. These receptors may play a role, albeit a poorly understood one, in the generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57e354c8de0cfd1711f0e2e30286b78
https://doi.org/10.1016/j.neuropharm.2018.08.032
https://doi.org/10.1016/j.neuropharm.2018.08.032