Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kathryn F Medler"'
Autor:
Debarghya Dutta Banik, Eric D Benfey, Laura E Martin, Kristen E Kay, Gregory C Loney, Amy R Nelson, Zachary C Ahart, Barrett T Kemp, Bailey R Kemp, Ann-Marie Torregrossa, Kathryn F Medler
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008925 (2020)
Taste receptor cells use multiple signaling pathways to detect chemicals in potential food items. These cells are functionally grouped into different types: Type I cells act as support cells and have glial-like properties; Type II cells detect bitter
Externí odkaz:
https://doaj.org/article/b64c3f5f5d00430ba7fd6f274fe93d67
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79403 (2013)
INTRODUCTION: Obesity is a growing epidemic that causes many serious health related complications. While the causes of obesity are complex, there is conclusive evidence that overconsumption coupled with a sedentary lifestyle is the primary cause of t
Externí odkaz:
https://doaj.org/article/7b880e7598914a6d956557b6c3893b52
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68174 (2013)
INTRODUCTION:WE REPORTED THAT RYANODINE RECEPTORS ARE EXPRESSED IN TWO DIFFERENT TYPES OF MAMMALIAN PERIPHERAL TASTE RECEPTOR CELLS: Type II and Type III cells. Type II cells lack voltage-gated calcium channels (VGCCs) and chemical synapses. In these
Externí odkaz:
https://doaj.org/article/66d7d5428b07461fb35def51423e77fc
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13639 (2010)
Multiple excitatory neurotransmitters have been identified in the mammalian taste transduction, with few studies focused on inhibitory neurotransmitters. Since the synthetic enzyme glutamate decarboxylase (GAD) for gamma-aminobutyric acid (GABA) is e
Externí odkaz:
https://doaj.org/article/aedd0d99bc6c40e3a0a8132cd8d3af4a
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are sent to the brain. We have previously identified a subpopulation of Type III taste cells that are broadly responsive (BR) and resp
Externí odkaz:
https://doaj.org/article/deec5ba65a49444da2c00c437ca292da
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104796- (2022)
Summary: The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Here we determine the role of BASP1 lipidation in histone modification and the modulation of ch
Externí odkaz:
https://doaj.org/article/33f7b2143b3442deb9ca641f850b4e4f
Publikováno v:
Current Opinion in Physiology. 20:159-164
The taste system uses distinct signaling pathways to detect chemicals in potential food items. Bitter, sweet and umami stimuli have complex chemical structures and activate G protein coupled receptor (GPCR) pathways while salt and sour are detected b
SummaryThe transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Here we determine the role of BASP1 lipidation in histone modification and the modulation of chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6797fc8d834d88709c9ab1d3cb22b26
https://doi.org/10.1101/2022.02.15.480538
https://doi.org/10.1101/2022.02.15.480538
Autor:
Kathryn F. Medler, Eneda Toska, Abigail R.E. Roberts, Alice Sherrard, Samantha Carrera, Alex Moorhouse, Anna F. Fleming, Stefan G. E. Roberts, Amy E. Loats
Publikováno v:
Dey, A E, Carrera, S, Fleming, A F, Roberts, A, Sherrard, A, Toska, E, Moorhouse, A, Medler, K F & Roberts, S G E 2021, ' Cholesterol is required for transcriptional repression by BASP1 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 29, e2101671118 . https://doi.org/10.1073/pnas.2101671118
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Cholesterol is present within the cell nucleus, where it associates with chromatin, but to date, a direct role for cholesterol in nuclear processes has not been identified. We demonstrate that the transcriptional repressor brain acid sol
Publikováno v:
Handbook of experimental pharmacology. 275
All organisms have the ability to detect chemicals in the environment, which likely evolved out of organisms' needs to detect food sources and avoid potentially harmful compounds. The taste system detects chemicals and is used to determine whether po