Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kathryn F, Medler"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Peripheral taste receptor cells use multiple signaling pathways to transduce taste stimuli into output signals that are sent to the brain. We have previously identified a subpopulation of Type III taste cells that are broadly responsive (BR) and resp
Externí odkaz:
https://doaj.org/article/deec5ba65a49444da2c00c437ca292da
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104796- (2022)
Summary: The transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Here we determine the role of BASP1 lipidation in histone modification and the modulation of ch
Externí odkaz:
https://doaj.org/article/33f7b2143b3442deb9ca641f850b4e4f
Autor:
Debarghya Dutta Banik, Eric D Benfey, Laura E Martin, Kristen E Kay, Gregory C Loney, Amy R Nelson, Zachary C Ahart, Barrett T Kemp, Bailey R Kemp, Ann-Marie Torregrossa, Kathryn F Medler
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008925 (2020)
Taste receptor cells use multiple signaling pathways to detect chemicals in potential food items. These cells are functionally grouped into different types: Type I cells act as support cells and have glial-like properties; Type II cells detect bitter
Externí odkaz:
https://doaj.org/article/b64c3f5f5d00430ba7fd6f274fe93d67
Publikováno v:
Current Opinion in Physiology. 20:159-164
The taste system uses distinct signaling pathways to detect chemicals in potential food items. Bitter, sweet and umami stimuli have complex chemical structures and activate G protein coupled receptor (GPCR) pathways while salt and sour are detected b
SummaryThe transcriptional corepressor BASP1 requires N-terminal myristoylation for its activity and functions through interactions with nuclear lipids. Here we determine the role of BASP1 lipidation in histone modification and the modulation of chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6797fc8d834d88709c9ab1d3cb22b26
https://doi.org/10.1101/2022.02.15.480538
https://doi.org/10.1101/2022.02.15.480538
Autor:
Eneda Toska, Hayley A. Campbell, Jayasha Shandilya, Sarah J. Goodfellow, Paul Shore, Kathryn F. Medler, Stefan G.E. Roberts
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 462-469 (2012)
The Wilms' tumor 1 protein WT1 is a transcriptional regulator that is involved in cell growth and differentiation. The transcriptional corepressor BASP1 interacts with WT1 and converts WT1 from a transcriptional activator to a repressor. Here, we dem
Externí odkaz:
https://doaj.org/article/7066041f837e47c09aa6357aefe6cc56
Autor:
Kathryn F. Medler, Eneda Toska, Abigail R.E. Roberts, Alice Sherrard, Samantha Carrera, Alex Moorhouse, Anna F. Fleming, Stefan G. E. Roberts, Amy E. Loats
Publikováno v:
Dey, A E, Carrera, S, Fleming, A F, Roberts, A, Sherrard, A, Toska, E, Moorhouse, A, Medler, K F & Roberts, S G E 2021, ' Cholesterol is required for transcriptional repression by BASP1 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 29, e2101671118 . https://doi.org/10.1073/pnas.2101671118
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Cholesterol is present within the cell nucleus, where it associates with chromatin, but to date, a direct role for cholesterol in nuclear processes has not been identified. We demonstrate that the transcriptional repressor brain acid sol
Publikováno v:
Handbook of experimental pharmacology. 275
All organisms have the ability to detect chemicals in the environment, which likely evolved out of organisms' needs to detect food sources and avoid potentially harmful compounds. The taste system detects chemicals and is used to determine whether po
Publikováno v:
The Pharmacology of Taste ISBN: 9783031064494
All organisms have the ability to detect chemicals in the environment, which likely evolved out of organisms' needs to detect food sources and avoid potentially harmful compounds. The taste system detects chemicals and is used to determine whether po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633278760b71737d977c4b41bc767a18
https://doi.org/10.1007/164_2021_442
https://doi.org/10.1007/164_2021_442
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79403 (2013)
INTRODUCTION: Obesity is a growing epidemic that causes many serious health related complications. While the causes of obesity are complex, there is conclusive evidence that overconsumption coupled with a sedentary lifestyle is the primary cause of t
Externí odkaz:
https://doaj.org/article/7b880e7598914a6d956557b6c3893b52