Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kathryn E. Kenworthy"'
Purpose: Organic anion-transporting polypeptide (OATP) drug uptake transporters are thought to play an important role in drug pharmacokinetics and toxicokinetics. We aimed to determine the influence of the individual human OATP1B1, OATP1B3, and OATP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51395895b4130d22711ff2299ba77a1a
https://doi.org/10.1158/1078-0432.c.6521525.v1
https://doi.org/10.1158/1078-0432.c.6521525.v1
PDF file - 86K,Descriptive RT-PCR data about the expression of other transporter proteins in livers of knockout and humanized transgenic OATP mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d17ed25334fceb43fcdde9a89c99d6
https://doi.org/10.1158/1078-0432.22448969.v1
https://doi.org/10.1158/1078-0432.22448969.v1
PDF file - 159K,Immunohistochemical staining of OATP1B3 in kidneys of humanized transgenic OATP1B3 mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b20bc46088199efa95d5ff78c689c5
https://doi.org/10.1158/1078-0432.22448975
https://doi.org/10.1158/1078-0432.22448975
PDF file - 101K, Tabular RT-PCR analysis results about the expression of other transporter proteins in livers of knockout and humanized transgenic OATP mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1868653c2e62b3230002ed32597dfc28
https://doi.org/10.1158/1078-0432.22448966.v1
https://doi.org/10.1158/1078-0432.22448966.v1
PDF file - 76K,Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9efb7e74259abe21d7656dfc0505c16
https://doi.org/10.1158/1078-0432.22448972
https://doi.org/10.1158/1078-0432.22448972
Publikováno v:
Clinical Cancer Research. 19:821-832
Purpose: Organic anion-transporting polypeptide (OATP) drug uptake transporters are thought to play an important role in drug pharmacokinetics and toxicokinetics. We aimed to determine the influence of the individual human OATP1B1, OATP1B3, and OATP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b400130f01eadae1d0b82a60b1df1660
https://doi.org/10.1158/1078-0432.ccr-12-2080
https://doi.org/10.1158/1078-0432.ccr-12-2080
Autor:
Rolf W. Sparidans, Evita van de Steeg, Els Wagenaar, Dilek Iusuf, Michael J Hobbs, Alfred H. Schinkel, Jos H. Beijnen, Anita van Esch, Kathryn E. Kenworthy
Publikováno v:
Molecular Pharmaceutics. 9:2497-2504
Organic anion-transporting polypeptides (OATPs) mediate the hepatic uptake of many drugs. Hepatic uptake is crucial for the therapeutic effect of pravastatin, a cholesterol-lowering drug and OATP1A/1B substrate. We aimed to gain empirical insight int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b91ed806ae54f21a827b6fcad22a361
https://doi.org/10.1021/mp300108c
https://doi.org/10.1021/mp300108c
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 341:2-15
Kinetic parameters describing hepatic uptake in hepatocytes are frequently estimated without appropriate incorporation of bidirectional passive diffusion, intracellular binding, and metabolism. A mechanistic two-compartment model was developed to des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20bc2b9fadcf846720760149890b339
https://doi.org/10.1124/jpet.111.187112
https://doi.org/10.1124/jpet.111.187112
Autor:
Els Wagenaar, Anita van Esch, Kathryn E. Kenworthy, Olaf van Tellingen, Alfred H. Schinkel, Cornelia M.M. van der Kruijssen, Evita van de Steeg
Publikováno v:
Clinical Cancer Research. 17:294-301
Purpose: Organic anion-transporting polypeptides (OATP) mediate the cellular uptake of a broad range of drugs. The hydrophobic anticancer drug, paclitaxel (PTX), was recently identified as a substrate for OATP1B3 in vitro. We investigated the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117eac7238385b5579638f98ef9b9b86
https://doi.org/10.1158/1078-0432.ccr-10-1980
https://doi.org/10.1158/1078-0432.ccr-10-1980
Autor:
Johanna E.C. Burggraaff, Dirk R. de Waart, Evita van de Steeg, Alfred H. Schinkel, Kathryn E. Kenworthy, Ronald P.J. Oude Elferink, Els Wagenaar, Cornelia M.M. van der Kruijssen
Publikováno v:
Journal of clinical investigation, 120(8), 2942-2952. The American Society for Clinical Investigation
The journal of clinical investigation, 120(8), 2942-2952. The American Society for Clinical Investigation
The journal of clinical investigation, 120(8), 2942-2952. The American Society for Clinical Investigation
Organic anion transporting polypeptides (OATPs) are uptake transporters for a broad range of endogenous compounds and xenobiotics. To investigate the physiologic and pharmacologic roles of OATPs of the 1A and 1B subfamilies, we generated mice lacking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40287003879e38f2ac0468ea4024bcd8
https://doi.org/10.1172/jci42168
https://doi.org/10.1172/jci42168