Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kathryn E. Blethen"'
Autor:
Tasneem A. Arsiwala, Samuel A. Sprowls, Kathryn E. Blethen, Ross A. Fladeland, Cullen P. Wolford, Brooke N. Kielkowski, Morgan J. Glass, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Manish Ranjan, Victor Finomore, Ali Rezai, Paul R. Lockman
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Systemic drug delivery to the central nervous system is limited by presence of the blood–brain barrier (BBB). Low intensity focused ultrasound (LiFUS) is a non-invasive technique to disrupt the BBB, though there is a lack of und
Externí odkaz:
https://doaj.org/article/ba4277831ec64d7eb08e3d7f77c1ff57
Autor:
Tasneem A. Arsiwala, Kathryn E. Blethen, Cullen P. Wolford, Dhruvi M. Panchal, Samuel A. Sprowls, Ross A. Fladeland, Brooke N. Kielkowski, Trenton A. Pritt, Peng Wang, Olivia Wilson, Jeffrey S. Carpenter, Victor Finomore, Ali Rezai, Paul R. Lockman
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Patients with metastatic breast cancer have high and continually increasing rates of brain metastases. During the course of the disease, brain metastases can occur in up to 30% of these patients. In most cases, brain metastases are diagnosed after si
Externí odkaz:
https://doaj.org/article/773747cdbf62440fa2b2e84f5e8746f5
Autor:
Jamie L. McCall, Melinda E. Varney, Emily Rice, Sebastian A. Dziadowicz, Casey Hall, Kathryn E. Blethen, Gangqing Hu, John B. Barnett, Ivan Martinez
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
ObjectivePrenatal cadmium (Cd) exposure leads to immunotoxic phenotypes in the offspring affecting coding and non-coding genes. Recent studies have shown that long non-coding RNAs (lncRNAs) are integral to T cell regulation. Here, we investigated the
Externí odkaz:
https://doaj.org/article/69de9cad5a064772b72aa5fc7945016a
Autor:
Samuel A. Sprowls, Pushkar Saralkar, Tasneem Arsiwala, Christopher E. Adkins, Kathryn E. Blethen, Vincenzo J. Pizzuti, Neal Shah, Ross Fladeland, Paul R. Lockman
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 756 (2021)
The blood–brain barrier (BBB) limits movement of solutes from the lumen of the brain microvascular capillary system into the parenchyma. The unidirectional transfer constant, Kin, is the rate at which transport across the BBB occurs for individual
Externí odkaz:
https://doaj.org/article/15ef5718add54c838960e80a268ef096
Autor:
Trenton A Pritt, Samuel A. Sprowls, Kathryn E Blethen, Tasneem Arsiwala, Brooke N. Kielkowski, Morgan J Glass, Yssabela M Cabuyao, Sonikpreet Aulakh, Ross Fladeland, Dhruvi M Panchal, Chris E. Adkins, Leland E Earp, Paul R. Lockman
Publikováno v:
Neuro-oncology Advances
The blood-brain barrier is the selectively permeable vasculature of the brain vital for maintaining homeostasis and neurological function. Low permeability is beneficial in the presence of toxins and pathogens in the blood. However, in the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350c5824fc01801d636a5dfbfb602b11
https://doi.org/10.1093/noajnl/vdab123
https://doi.org/10.1093/noajnl/vdab123
Autor:
Samuel A. Sprowls, W. Pentz, Manish Ranjan, A. Gabriele, Brooke N. Kielkowski, Jeffrey S Carpenter, Pushkar Saralkar, Rashi I. Mehta, Paul R. Lockman, Ross Fladeland, Peng Wang, Tasneem Arsiwala, Chris E. Adkins, Kathryn E Blethen, Ali R. Rezai, Umer Najib
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 7, Pp 676-691 (2021)
The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bce52dd68e77db39bf5423f5169f36
http://europepmc.org/articles/PMC8208897
http://europepmc.org/articles/PMC8208897
Overcoming the acquired resistance to gefitinib in lung cancer brain metastasis in vitro and in vivo
Autor:
Kent L Marshall, Paul R. Lockman, Kathryn E Blethen, Tasneem Arsiwala, Zhongwei Liu, Neal Shah, Afroz S. Mohammad, Weimin Gao, Samuel A. Sprowls, Pushkar Saralkar, Ross Fladeland
Publikováno v:
Arch Toxicol
In our previous work, PC-9-Br, a PC-9 brain seeking line established via a preclinical animal model of lung cancer brain metastasis (LCBM), exhibited not only resistance to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) gefitin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad206ef770df0749b0375dcb3a11885
https://pubmed.ncbi.nlm.nih.gov/34455456
https://pubmed.ncbi.nlm.nih.gov/34455456
Autor:
Jamie L. McCall, Ivan Martinez, Melinda E. Varney, Gangqing Hu, John B. Barnett, Dziadowicz Sa, Casey Hall, Kathryn E Blethen
ObjectivePrenatal cadmium (Cd) exposure leads to immunotoxic phenotypes in the offspring affecting coding and non-coding genes. Recent studies have shown that long non-coding RNAs (lncRNAs) are integral to T cell regulation. Here, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183c518cef00db0cf9bebf94f8c36be9
https://doi.org/10.1101/2021.06.04.446938
https://doi.org/10.1101/2021.06.04.446938
Autor:
Tasneem A. Arsiwala, Kathryn E. Blethen, Samuel A. Sprowls, Ross A. Fladeland, Brooke Keilkowski, Morgan Glass, Trenton Pritt, Peng Wang, Ali Rezai, Paul R. Lockman
Publikováno v:
Cancer Research. 82:3461-3461
Background: Incidence of patients having brain metastasis of breast cancer has increased due to enhanced treatment for peripheral disease. Breast cancer brain metastasis is often fatal and occurs in 15-20% of patients diagnosed with stage IV breast c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8618af8c86cb3be27209214150cd74a3
https://doi.org/10.1158/1538-7445.am2022-3461
https://doi.org/10.1158/1538-7445.am2022-3461
Autor:
Neal Shah, Ross Fladeland, Paul R. Lockman, Tasneem Arsiwala, Kathryn E Blethen, Dhruvi M Panchal, Weimin Gao, Brooke N. Kielkowski, Samuel A. Sprowls
Publikováno v:
Neuro-Oncology Advances. 3:iv8-iv8
Lung cancer is the most prevalent malignancy to affect both men and women. Around 80% of all lung cancers are classified as non-small cell lung cancer (NSCLC). This subtype of lung cancer is also the most likely to metastasize to the brain. Clinicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9151b36cd81fa10149c9d01b1dd06f41
https://doi.org/10.1093/noajnl/vdab112.030
https://doi.org/10.1093/noajnl/vdab112.030