Výsledky vyhledávání - "Kathryn E Ware"

Akademický článek

Rapidly acquired resistance to EGFR tyrosine kinase inhibitors in NSCLC cell lines through de-repression of FGFR2 and FGFR3 expression.

Autor: Kathryn E Ware, Marianne E Marshall, Lydia R Heasley, Lindsay Marek, Trista K Hinz, Paula Hercule, Barbara A Helfrich, Robert C Doebele, Lynn E Heasley

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14117 (2010)

Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression analysis of NSCLC cell lines treated with the EGFR TKI, gefitinib, revealed increased levels of FG

Externí odkaz: https://doaj.org/article/46fcf9c01b6b4995a8fad7b7b0c4e4d2

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Akademický článek

Emergent dynamics of underlying regulatory network links EMT and androgen receptor-dependent resistance in prostate cancer

Autor: Rashi Jindal, Abheepsa Nanda, Maalavika Pillai, Kathryn E. Ware, Divyoj Singh, Manas Sehgal, Andrew J. Armstrong, Jason A. Somarelli, Mohit Kumar Jolly

Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1498-1509 (2023)

Advanced prostate cancer patients initially respond to hormone therapy, be it in the form of androgen deprivation therapy or second-generation hormone therapies, such as abiraterone acetate or enzalutamide. However, most men with prostate cancer even

Externí odkaz: https://doaj.org/article/f5cf7b96175f41dbb8499a06f75362be

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Akademický článek

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Autor: Kathryn E. Ware, Beatrice C. Thomas, Pelumi D. Olawuni, Maya U. Sheth, Nathan Hawkey, M. Yeshwanth, Brian C. Miller, Katherine J. Vietor, Mohit Kumar Jolly, So Young Kim, Andrew J. Armstrong, Jason A. Somarelli

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone therapy-resistant and metastatic prostate cancer remains a major cause of cancer-related death globally. The mainstay of treatment for advanced p

Externí odkaz: https://doaj.org/article/1387a5257992495d9a15d49c7db46780

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Akademický článek

Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer

Autor: Erdem Altunel, Roham S. Roghani, Kai-Yuan Chen, So Young Kim, Shannon McCall, Kathryn E. Ware, Xiling Shen, Jason A. Somarelli, David S. Hsu

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)

Abstract Background Metastatic colorectal cancer (CRC) continues to be a major health problem, and current treatments are primarily for disease control and palliation of symptoms. In this study, we developed a precision medicine strategy to discover

Externí odkaz: https://doaj.org/article/7572fef9fbcb4d56a7ff843e9206f4f0

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