Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Kathryn E Ware"'
Autor:
Rashi Jindal, Abheepsa Nanda, Maalavika Pillai, Kathryn E. Ware, Divyoj Singh, Manas Sehgal, Andrew J. Armstrong, Jason A. Somarelli, Mohit Kumar Jolly
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1498-1509 (2023)
Advanced prostate cancer patients initially respond to hormone therapy, be it in the form of androgen deprivation therapy or second-generation hormone therapies, such as abiraterone acetate or enzalutamide. However, most men with prostate cancer even
Externí odkaz:
https://doaj.org/article/f5cf7b96175f41dbb8499a06f75362be
Autor:
Kathryn E. Ware, Beatrice C. Thomas, Pelumi D. Olawuni, Maya U. Sheth, Nathan Hawkey, M. Yeshwanth, Brian C. Miller, Katherine J. Vietor, Mohit Kumar Jolly, So Young Kim, Andrew J. Armstrong, Jason A. Somarelli
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone therapy-resistant and metastatic prostate cancer remains a major cause of cancer-related death globally. The mainstay of treatment for advanced p
Externí odkaz:
https://doaj.org/article/1387a5257992495d9a15d49c7db46780
Autor:
Erdem Altunel, Roham S. Roghani, Kai-Yuan Chen, So Young Kim, Shannon McCall, Kathryn E. Ware, Xiling Shen, Jason A. Somarelli, David S. Hsu
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Metastatic colorectal cancer (CRC) continues to be a major health problem, and current treatments are primarily for disease control and palliation of symptoms. In this study, we developed a precision medicine strategy to discover
Externí odkaz:
https://doaj.org/article/7572fef9fbcb4d56a7ff843e9206f4f0
Autor:
Sneha R. Rao, Jason A. Somarelli, Erdem Altunel, Laura E. Selmic, Mark Byrum, Maya U. Sheth, Serene Cheng, Kathryn E. Ware, So Young Kim, Joseph A. Prinz, Nicolas Devos, David L. Corcoran, Arthur Moseley, Erik Soderblom, S. David Hsu, William C. Eward
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Cancer drug discovery is an inefficient process, with more than 90% of newly-discovered therapies failing to gain regulatory approval. Patient-derived models of cancer offer a promising new approach to identify new treatments; however, for rare cance
Externí odkaz:
https://doaj.org/article/a1b074c0c7074ef989692b122dfeeb45
Autor:
Jason A. Somarelli, Herbert Levine, William C. Eward, Mark W. Dewhirst, Andrew J. Armstrong, Dharshan Sivaraj, Drew G. Gerber, David L. Kerr, Alexander L. Lazarides, Mary-Keara Boss, R. Timothy Kreulen, Jason T. George, Suzanne Bartholf DeWitt, Alexander J. Hish, Daniella Runyambo, R. Garland Austin, Xueyang Wang, Yanjun Yang, Samantha Shetler, Shivee Gilja, Shengnan Xu, Kathryn E. Ware, Mohit Kumar Jolly
S4. E-cadherin induces E- to N-cadherin switching in sarcoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f209d415123522cbf4035c5b45caa44
https://doi.org/10.1158/1541-7786.22516408
https://doi.org/10.1158/1541-7786.22516408
Autor:
Jason A. Somarelli, Herbert Levine, William C. Eward, Mark W. Dewhirst, Andrew J. Armstrong, Dharshan Sivaraj, Drew G. Gerber, David L. Kerr, Alexander L. Lazarides, Mary-Keara Boss, R. Timothy Kreulen, Jason T. George, Suzanne Bartholf DeWitt, Alexander J. Hish, Daniella Runyambo, R. Garland Austin, Xueyang Wang, Yanjun Yang, Samantha Shetler, Shivee Gilja, Shengnan Xu, Kathryn E. Ware, Mohit Kumar Jolly
CDH1 (also known as E-cadherin), an epithelial-specific cell–cell adhesion molecule, plays multiple roles in maintaining adherens junctions, regulating migration and invasion, and mediating intracellular signaling. Downregulation of E-cadherin is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f7608b3b5dd14c3e4bf7f69fb9360e
https://doi.org/10.1158/1541-7786.c.6541357
https://doi.org/10.1158/1541-7786.c.6541357
Autor:
Jason A. Somarelli, Herbert Levine, William C. Eward, Mark W. Dewhirst, Andrew J. Armstrong, Dharshan Sivaraj, Drew G. Gerber, David L. Kerr, Alexander L. Lazarides, Mary-Keara Boss, R. Timothy Kreulen, Jason T. George, Suzanne Bartholf DeWitt, Alexander J. Hish, Daniella Runyambo, R. Garland Austin, Xueyang Wang, Yanjun Yang, Samantha Shetler, Shivee Gilja, Shengnan Xu, Kathryn E. Ware, Mohit Kumar Jolly
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27330c9cb7455703ffdec26a904103c6
https://doi.org/10.1158/1541-7786.22516396
https://doi.org/10.1158/1541-7786.22516396
Autor:
David S. Hsu, Christopher R. Mantyh, Xiling Shen, Shannon J. McCall, So Young Kim, John B. Mantyh, Erdem Altunel, Kathryn E. Ware, Gabrielle Rupprecht, Beatrice C. Thomas, Ali Sanjari Moghaddam, Roham Salman Roghani, Jason A. Somarelli
Patient demographic are described in supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1a2a788249995c0f19c463fcea192b
https://doi.org/10.1158/1535-7163.22521145
https://doi.org/10.1158/1535-7163.22521145
Autor:
David S. Hsu, Christopher R. Mantyh, Xiling Shen, Shannon J. McCall, So Young Kim, John B. Mantyh, Erdem Altunel, Kathryn E. Ware, Gabrielle Rupprecht, Beatrice C. Thomas, Ali Sanjari Moghaddam, Roham Salman Roghani, Jason A. Somarelli
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db04022734a7acd8885f2eeca0698da
https://doi.org/10.1158/1535-7163.22521148.v1
https://doi.org/10.1158/1535-7163.22521148.v1
Autor:
Ella F Gunady, Kathryn E Ware, Sarah Hoskinson Plumlee, Nicolas Devos, David Corcoran, Joseph Prinz, Hrvoje Misetic, Francesca D Ciccarelli, Tara M Harrison, Jeffrey L Thorne, Robert Schopler, Jeffrey I Everitt, William C Eward, Jason A Somarelli
Publikováno v:
Evolution, Medicine, and Public Health. 10:221-230
Background and objectives Hepatocellular carcinoma occurs frequently in prosimians, but the cause of these liver cancers in this group is unknown. Characterizing the genetic changes associated with hepatocellular carcinoma in prosimians may point to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd62a86aca40881a00fa4de6040a2dd6
https://doi.org/10.1093/emph/eoac016
https://doi.org/10.1093/emph/eoac016