Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Kathryn E Carlson"'
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, Kendall W Nettles
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp 1-14 (2016)
Abstract Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants
Externí odkaz:
https://doaj.org/article/cf1c1a8640554626b04f8b7d235ebf06
Autor:
Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi, Gilles Buchwalter, René Houtman, Weiyi Toy, Colin E Fowler, Ross Han, Muriel Lainé, Kathryn E Carlson, Teresa A Martin, Jason Nowak, Jerome C Nwachukwu, David J Hosfield, Sarat Chandarlapaty, Emad Tajkhorshid, Kendall W Nettles, Patrick R Griffin, Yang Shen, John A Katzenellenbogen, Myles Brown, Geoffrey L Greene
Publikováno v:
eLife, Vol 7 (2018)
Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the ESR1 (estrogen receptor alpha (ERα)) gene ligand-binding domain (LBD) represent a recognized mechanism of acquired re
Externí odkaz:
https://doaj.org/article/582b84ec644248bbb6fb9af5a9be5532
Autor:
Sean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, Kathryn E Carlson, Teresa A Martin, Scott J Novick, Weiyi Toy, Bradley Green, Srinivas Panchamukhi, Benita S Katzenellenbogen, Emad Tajkhorshid, Patrick R Griffin, Yang Shen, Sarat Chandarlapaty, John A Katzenellenbogen, Geoffrey L Greene
Publikováno v:
eLife, Vol 5 (2016)
Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1), especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies. Cell-based studies demonstrated that these mutants confer ERα constitutive activity and
Externí odkaz:
https://doaj.org/article/d72eb07c0ab74842a4752908808171ae
Autor:
Sarat Chandarlapaty, José Baselga, Geoffrey Greene, John A. Katzenellenbogen, Sean Fanning, Zhiqiang Li, Sharmeen Uddin, Teresa S. Martin, Kathryn E. Carlson, Elisa De Stanchina, Wai Lin Wong, Christopher Morrow, Joanne Wilson, Aaron Smith, Anne Marie Mazzola, Anne U. Goeppert, Mandy Lawson, Pedram Razavi, Hazel Weir, Weiyi Toy
Supplementary Figures 1 - 8, Tables 1 - 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dff68a706294f698444df25bf64477e
https://doi.org/10.1158/2159-8290.22531658
https://doi.org/10.1158/2159-8290.22531658
Autor:
Sarat Chandarlapaty, José Baselga, Geoffrey Greene, John A. Katzenellenbogen, Sean Fanning, Zhiqiang Li, Sharmeen Uddin, Teresa S. Martin, Kathryn E. Carlson, Elisa De Stanchina, Wai Lin Wong, Christopher Morrow, Joanne Wilson, Aaron Smith, Anne Marie Mazzola, Anne U. Goeppert, Mandy Lawson, Pedram Razavi, Hazel Weir, Weiyi Toy
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f9ecf550815949a98ad6508793ed05
https://doi.org/10.1158/2159-8290.22531655
https://doi.org/10.1158/2159-8290.22531655
Autor:
Filippo Minutolo, Simone Bertini, Adriano Martinelli, Gabriella Ortore, Giorgio Placanica, Giovanni Prota, Simona Rapposelli, Tiziano Tuccinardi, Shubin Sheng, Kathryn E. Carlson, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Marco Macchia
Publikováno v:
ARKIVOC, Vol 2006, Iss 8, Pp 83-94 (2006)
Externí odkaz:
https://doaj.org/article/edb5b22c6e74416abbf70506d172d6c4
Autor:
Sung Hoon Kim, Kathryn E. Carlson, Tina Izard, Benita S. Katzenellenbogen, Scott J. Novick, Jerome C. Nwachukwu, René Houtman, Charles C. Nettles, Yingwei Hou, Sathish Srinivasan, Jian Min, Yvonne S. Ziegler, Kendall W. Nettles, Shunchao Yan, Patrick R. Griffin, Bruce D. Pascal, John A. Katzenellenbogen, Charles K Min, Valeria Sanabria Guillen, Erumbi S. Rangarajan, Jacqline W Njeri
Publikováno v:
Proc Natl Acad Sci U S A
Efforts to improve estrogen receptor-α (ER)-targeted therapies in breast cancer have relied upon a single mechanism, with ligands having a single side chain on the ligand core that extends outward to determine antagonism of breast cancer growth. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4adc494dbce92f7879e15f3f8c31eb
https://pubmed.ncbi.nlm.nih.gov/34452998
https://pubmed.ncbi.nlm.nih.gov/34452998
Autor:
Emad Tajkhorshid, Benita S. Katzenellenbogen, Christopher G. Mayne, Weiyi Toy, Geoffrey L. Greene, John A. Katzenellenbogen, Trusha Bhatt, Sean W. Fanning, Sarat Chandarlapaty, Kathryn E. Carlson
Publikováno v:
Mol Cancer Res
Although most primary estrogen receptor (ER)–positive breast cancers respond well to endocrine therapies, many relapse later as metastatic disease due to endocrine therapy resistance. Over one third of these are associated with mutations in the lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759ea5aec872622f4955462d3651e808
https://pubmed.ncbi.nlm.nih.gov/34021071
https://pubmed.ncbi.nlm.nih.gov/34021071
Autor:
Teresa A. Martin, Yin Li, Christopher G. Mayne, Laurel A. Coons, René Houtman, Kathryn E. Carlson, Diana Melchers, John A. Katzenellenbogen, J. Tyler Ramsey, Tanner B. Jefferson, Kenneth S. Korach
Publikováno v:
Sci Signal
A homozygous missense mutation in the gene encoding the estrogen receptor α (ERα) was previously identified in a female patient with estrogen insensitivity syndrome. We investigated the molecular features underlying the impaired transcriptional res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5736e1f3d3f406da0d96ecea154fdbe2
https://doi.org/10.1126/scisignal.aaw4653
https://doi.org/10.1126/scisignal.aaw4653
Autor:
Jian Min, Yvonne S. Ziegler, Sung Hoon Kim, Tina Izard, Charles C. Nettles, Kendall W. Nettles, Erumbi S. Rangarajan, Benita S. Katzenellenbogen, Jerome C. Nwachukwu, Yingwei Hou, Sathish Srinivasan, Patrick R. Griffin, Valeria Sanabria Guillen, John A. Katzenellenbogen, Kathryn E. Carlson, Shunchao Yan, Bruce D. Pascal, René Houtman, Scott J. Novick
Efforts to improve estrogen receptor-a (ER)-targeted therapies in breast cancer have relied upon a single mechanism, with ligands having a single side chain on the ligand core that extends outward to determine antagonism of breast cancer growth. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6e991f766c6f1ea7f93c52fa0b64d5b
https://doi.org/10.1101/2020.07.06.189977
https://doi.org/10.1101/2020.07.06.189977