Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Kathryn E, Stein"'
Autor:
Scott Koenig, Anastasia G. Daifotis, David Carlin, William Hagopian, Kevan C. Herold, Robert J. Ferry, Kathryn E. Stein, Syd Johnson, Nicole A. Sherry, Ezio Bonvini, Johnny Ludvigsson
Publikováno v:
Diabetes
Protege was a phase 3, randomized, double-blind, parallel, placebo-controlled 2-year study of three intravenous teplizumab dosing regimens, administered daily for 14 days at baseline and again after 26 weeks, in new-onset type 1 diabetes. We sought t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f018d8db157ef74cc3309817e1bc0551
https://doi.org/10.2337/db13-0236
https://doi.org/10.2337/db13-0236
Autor:
Kathryn E. Stein, Nadine Tuaillon, Misty Troutt, Meghan M. Flaherty, Richard D. Garman, Laura Andrews, Tomas Magee, Ezio Bonvini, Timothy K. MacLachlan, Syd Johnson
Publikováno v:
Toxicological Sciences. 125:299-309
Fc receptors are a critical component of the innate immune system responsible for the recognition of cross-linked antibodies and the subsequent clearance of pathogens. However, in autoimmune diseases, these receptors play a role in the deleterious ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2476a856b3eefc08cca6dc7707b9f5
https://doi.org/10.1093/toxsci/kfr278
https://doi.org/10.1093/toxsci/kfr278
Autor:
Nicole, Sherry, William, Hagopian, Johnny, Ludvigsson, Sunil M, Jain, Jack, Wahlen, Robert J, Ferry, Bruce, Bode, Stephen, Aronoff, Christopher, Holland, David, Carlin, Karen L, King, Ronald L, Wilder, Stanley, Pillemer, Ezio, Bonvini, Syd, Johnson, Kathryn E, Stein, Scott, Koenig, Kevan C, Herold, Anastasia G, Daifotis
Publikováno v:
The Lancet. 378:487-497
Summary Background Findings of small studies have suggested that short treatments with anti-CD3 monoclonal antibodies that are mutated to reduce Fc receptor binding preserve β-cell function and decrease insulin needs in patients with recent-onset ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8b7de963880d3cb9b94f0790f3a34b
https://doi.org/10.1016/s0140-6736(11)60931-8
https://doi.org/10.1016/s0140-6736(11)60931-8
Publikováno v:
Nature Biotechnology. 25:555-561
Bioanalytical assessments of anti-drug antibodies (ADAs) provide an understanding of the immunogenicity of biological drug molecules. The potential to induce ADAs after treatment with biologics is a safety issue that has become an important considera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2c55d59f53d5146fd13ca5d4ba7d03
https://doi.org/10.1038/nbt1303
https://doi.org/10.1038/nbt1303
Publikováno v:
Infection and Immunity. 72:3451-3460
Antibody (Ab) responses to polysaccharides (PS), such asNeisseria meningitidisgroup C PS (MCPS), are characterized as being thymus independent and are restricted with regard to clonotype and isotype expression. PS conjugated to proteins, e.g., MCPS c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451fc4c6aa633be928545d07c89d03a4
https://doi.org/10.1128/iai.72.6.3451-3460.2004
https://doi.org/10.1128/iai.72.6.3451-3460.2004
Publikováno v:
Immunogenetics. 55:80-86
Previous studies demonstrated that the diversity of the antibody response of mice to the inulin (In) determinant of bacterial levan is regulated by the gene Spectrotype Regulation 1 ( Sr1). BALB/c mice produce a monoclonal anti-In response as shown b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f238de8a24586cc4055d1a59bf39489
https://doi.org/10.1007/s00251-003-0555-z
https://doi.org/10.1007/s00251-003-0555-z
Autor:
Christina de Wit, Kathryn E. Stein, Gian D. Polastri, Elizabeth Hamilton, Robert Kiss, Ron Taticek, Mehnaz Mustafa, Patrick G. Swann, Yuan Xu, Kurt Brorson
Publikováno v:
Biotechnology and Bioengineering. 80:257-267
Cell culture process changes (e.g., changes in scale, medium formulation, operational conditions) and cell line changes are common during the development life cycle of a therapeutic protein. To ensure that the impact of such process changes on produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd5158b8aacc84a51191f6061c607a5
https://doi.org/10.1002/bit.10366
https://doi.org/10.1002/bit.10366
Autor:
Elizabeth Hamilton, Lenore A. Norling, Mehnaz Mustafa, Patrick G. Swann, Yuan Xu, Kurt Brorson, Christina de Wit, Kathryn E. Stein
Publikováno v:
Biologicals. 30:15-26
Murine hybridoma cells used in the production of monoclonal antibodies (mAbs) produce endogenous type C retrovirus particles. Regulatory agencies require a demonstration that mAbs intended for human use are free of retrovirus with an adequate margin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdac34ad27319bf8e99cf2e6be5eb60
https://doi.org/10.1006/biol.2001.0290
https://doi.org/10.1006/biol.2001.0290
Autor:
Kathryn E. Stein, Keith O Webber
Publikováno v:
Current Opinion in Biotechnology. 12:308-311
Recently, there has been a large increase in the number and types of biological products — from therapeutic antibodies to vaccines for the prevention of infectious diseases — that are produced in bioengineered plant systems. We anticipate that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e618f1ef499aaac14be39ff8dea3886d
https://doi.org/10.1016/s0958-1669(00)00217-2
https://doi.org/10.1016/s0958-1669(00)00217-2
Publikováno v:
Biotechnology Progress. 17:188-196
Murine hybridoma cells used in the production of monoclonal antibodies (mAb's) produce endogenous type C retrovirus particles. Regulatory agencies require a demonstration that mAb's intended for human use are free of retrovirus with an adequate margi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d0d24ec0ce822b92af43b160eb5830
https://doi.org/10.1021/bp000153q
https://doi.org/10.1021/bp000153q