Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Kathryn E, Hamilton"'
Autor:
Masaru Sasaki, Takeo Hara, Joshua X. Wang, Yusen Zhou, Kanak V. Kennedy, Chizoba N. Umeweni, Maiya A. Alston, Zachary C. Spergel, Satoshi Ishikawa, Ryugo Teranishi, Ritsu Nakagawa, Emily A. Mcmillan, Kelly A. Whelan, Tatiana A. Karakasheva, Kathryn E. Hamilton, Melanie A. Ruffner, Amanda B. Muir
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 923-937 (2024)
Background & Aims: Epithelial disruption in eosinophilic esophagitis (EoE) encompasses both impaired differentiation and diminished barrier integrity. We have shown that lysyl oxidase (LOX), a collagen cross-linking enzyme, is up-regulated in the eso
Externí odkaz:
https://doaj.org/article/4642d52f7d81435797854e2d8c616673
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Autor:
Louis R. Parham, Patrick A. Williams, Kay Katada, Shaneice K. Nettleford, Priya Chatterji, Kofi K. Acheampong, Charles H. Danan, Xianghui Ma, Lauren A. Simon, Kaitlyn E. Naughton, Rei Mizuno, Tatiana Karakasheva, Emily A. McMillan, Kelly A. Whelan, Donita C. Brady, Sydney M. Shaffer, Kathryn E. Hamilton
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 439-451 (2024)
Background & Aims: The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative intestinal stem cells are cells that survive tissue injury and divide to re-establ
Externí odkaz:
https://doaj.org/article/2d55833f363e489b8c29b533990b04ea
Autor:
Tatiana A. Karakasheva, Yusen Zhou, Hongbo M. Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn Naughton, Lauren Dolinsky, James A. Pippin, Andrew D. Wells, Struan F.A. Grant, Louis Ghanem, Natalie Terry, Amanda B. Muir, Kathryn E. Hamilton
Publikováno v:
Gastro Hep Advances, Vol 2, Iss 6, Pp 830-842 (2023)
Background and Aims: A key histopathological feature of inflammatory bowel disease is damage to the mucosa, including breakdown of the epithelial barrier. Human enteroids and colonoids are a critical bench-to-bedside tool for studying the epithelium
Externí odkaz:
https://doaj.org/article/3b5bbb61491c43eda5c548a0bbb7c298
Autor:
Mohammad Faujul Kabir, Adam L. Karami, Ricardo Cruz-Acuña, Alena Klochkova, Reshu Saxena, Anbin Mu, Mary Grace Murray, Jasmine Cruz, Annie D. Fuller, Margarette H. Clevenger, Kumaraswamy Naidu Chitrala, Yinfei Tan, Kelsey Keith, Jozef Madzo, Hugh Huang, Jaroslav Jelinek, Tatiana Karakasheva, Kathryn E. Hamilton, Amanda B. Muir, Marie-Pier Tétreault, Kelly A. Whelan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The level of cellular diversity in the esophageal epithelium has yet to be classified at the single cell level. Here the authors analyze the transcriptome of 44,679 murine esophageal keratinocytes to identify an unexpected level of cellular heterogen
Externí odkaz:
https://doaj.org/article/08d60dfa06354f1792c694cb232b3b9d
Autor:
Takeo Hara, Yuta Kasagi, Joshua Wang, Masaru Sasaki, Bailey Aaron, Adam Karami, Masataka Shimonosono, Rieko Shimonosono, Hisatsugu Maekawa, Lauren Dolinsky, Benjamin Wilkins, Jeremy Klein, Jane Wei, Kathryn Nunes, Kristle Lynch, Jonathan M. Spergel, Kathryn E. Hamilton, Melanie A. Ruffner, Tatiana A. Karakasheva, Kelly A. Whelan, Hiroshi Nakagawa, Amanda B. Muir
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1449-1467 (2022)
Background & Aims: Although basal cell hyperplasia is a histologic hallmark of eosinophilic esophagitis (EoE), little is known about the capabilities of epithelial renewal and differentiation in the EoE inflammatory milieu. In murine esophageal epith
Externí odkaz:
https://doaj.org/article/6cf51597b7804a5da4a9fd173aba4b20
Autor:
Tatiana A. Karakasheva, Joel T. Gabre, Uma M. Sachdeva, Ricardo Cruz-Acuña, Eric W. Lin, Maureen DeMarshall, Gary W. Falk, Gregory G. Ginsberg, Zhaohai Yang, Michele M. Kim, Eric S. Diffenderfer, Jason R. Pitarresi, Jinyang Li, Amanda B. Muir, Kathryn E. Hamilton, Hiroshi Nakagawa, Adam J. Bass, Anil K. Rustgi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract 3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patient
Externí odkaz:
https://doaj.org/article/43bca536a467471b9f4d262b3322f68e
Autor:
Patrick A. Williams, Kaitlyn E. Naughton, Lauren A. Simon, Gloria E. Soto, Louis R. Parham, Xianghui Ma, Charles H. Danan, Weiming Hu, Elliot S. Friedman, Emily A. McMillan, Hritik Mehta, Madison A. Stoltz, Joshua Soto Ocaña, Joseph P. Zackular, Kyle Bittinger, Kelly A. Whelan, Tatiana A. Karakasheva, Kathryn E. Hamilton
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G354-G368
Calorie restriction is associated with enhanced intestinal regeneration after irradiation, but the requirement of autophagy for this process is not known. Our data support the premise that intestinal epithelial autophagy is required for the regenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44fc3763373a94ce9dc3378294b45837
https://doi.org/10.1152/ajpgi.00248.2022
https://doi.org/10.1152/ajpgi.00248.2022
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G91-G98
The profound complexity of the intestinal mucosa demands a spatial approach to the study of gut transcriptomics. Although single-cell RNA sequencing has revolutionized our ability to survey the diverse cell types of the intestine, knowledge of cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c2c3c24b99e19b4833d530705cd49d
https://doi.org/10.1152/ajpgi.00191.2022
https://doi.org/10.1152/ajpgi.00191.2022
Autor:
Yuta Kasagi, Prasanna M. Chandramouleeswaran, Kelly A. Whelan, Koji Tanaka, Veronique Giroux, Medha Sharma, Joshua Wang, Alain J. Benitez, Maureen DeMarshall, John W. Tobias, Kathryn E. Hamilton, Gary W. Falk, Jonathan M. Spergel, Andres J. Klein-Szanto, Anil K. Rustgi, Amanda B. Muir, Hiroshi Nakagawa
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 333-352 (2018)
Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is needed to stud
Externí odkaz:
https://doaj.org/article/21163af81d7441fbb6e128ef99587eeb