Výsledky vyhledávání - "Kathryn Dorsey"

Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

Autor: Jonathan H, Fox, Teal, Connor, Megan, Stiles, Jibrin, Kama, Zhen, Lu, Kathryn, Dorsey, Gregory, Lieberman, Gregory, Liebermann, Ellen, Sapp, Robert A, Cherny, Mary, Banks, Irene, Volitakis, Marian, DiFiglia, Oksana, Berezovska, Ashley I, Bush, Steven M, Hersch

Publikováno v: Journal of Biological Chemistry. 286:18320-18330

Huntington disease (HD) is a progressive neurodegenerative disorder caused by expression of polyglutamine-expanded mutant huntingtin protein (mhtt). Most evidence indicates that soluble mhtt species, rather than insoluble aggregates, are the importan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8993ab0204e89d88b691d216226373
https://doi.org/10.1074/jbc.m110.199448

Zobrazit plný text záznamu

A small-molecule therapeutic lead for Huntington's disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse

Autor: Peter Waldmeier, Jonathan H. Fox, Anne B. Young, Aleksey G. Kazantsev, Greg Lieberman, Vanita Chopra, Steven M. Hersch, David E. Housman, Wayne R. Matson, Kathryn Dorsey

Publikováno v: Proceedings of the National Academy of Sciences. 104:16685-16689

Huntington's disease (HD) is a progressive neurodegenerative disease caused by a glutamine expansion within huntingtin protein. The exact pathological mechanisms determining disease onset and progression remain unclear. However, aggregates of insolub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f895de31dcb29e7deba4553e905610d3
https://doi.org/10.1073/pnas.0707842104

Zobrazit plný text záznamu

Pharmacokinetics of sustained-release analgesics in mice

Autor: Lon V, Kendall, Ryan J, Hansen, Kathryn, Dorsey, Sooah, Kang, Paul J, Lunghofer, Daniel L, Gustafson

Publikováno v: Journal of the American Association for Laboratory Animal Science : JAALAS. 53(5)

Buprenorphine and carprofen, 2 of the most commonly used analgesics in mice, must be administered every 8 to 12 h to provide sustained analgesia. Sustained-release (SR) formulations of analgesics maintain plasma levels that should be sufficient to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03ec77ebdfb094ce38330d9a5d1d646d
https://pubmed.ncbi.nlm.nih.gov/25255070

Zobrazit plný text záznamu