Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kathryn D. Mouzakis"'
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Objectives Reactive oxygen species (ROS) oxidize guanine residues in DNA to form 7,8-dihydro-oxo-2′-deoxyguanosine (8oxoG) lesions in the genome. Human 8-oxoguanine glycosylase-1 (hOGG1) recognizes and excises this highly mutagenic species
Externí odkaz:
https://doaj.org/article/939fe51082ac4100ac9322bc41acc3a5
Autor:
Mary Soliman, Leila Robinson, Madison Maille, Carolyn Egekeze, Rebecca Salamon, Kathryn D. Mouzakis
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe5e44949a3b68311f4562dec5352bf
https://doi.org/10.1096/fasebj.2022.36.s1.l6403
https://doi.org/10.1096/fasebj.2022.36.s1.l6403
Autor:
Madison M. Maille, Kathryn D. Mouzakis
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b32ffa16185a823231fcaa75ad5aa92d
https://doi.org/10.1096/fasebj.2022.36.s1.l6402
https://doi.org/10.1096/fasebj.2022.36.s1.l6402
Autor:
Robert J. Gorelick, Pablo García-Miranda, Kevin M. Weeks, Justin T. Low, Samuel E. Butcher, Kathryn D. Mouzakis
Publikováno v:
Biochemistry
The HIV-1 ribosomal frameshift element is highly structured, regulates translation of all virally encoded enzymes, and is a promising therapeutic target. The prior model for this motif contains two helices separated by a three-nucleotide bulge. Modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbf2987cc99cad1eb715d6a51451c6e
https://doi.org/10.1021/bi5004926
https://doi.org/10.1021/bi5004926
Publikováno v:
ACS Chemical Biology. 4:844-854
HIV-1 requires a -1 translational frameshift to properly synthesize the viral enzymes required for replication. The frameshift mechanism is dependent upon two RNA elements, a seven-nucleotide slippery sequence (UUUUUUA) and a downstream RNA structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409f3f7081b0749213094568166e6afd
https://doi.org/10.1021/cb900167m
https://doi.org/10.1021/cb900167m
Autor:
Qian Ren, Eric Jan, Jordan E. Burke, Kathryn D. Mouzakis, Seonghoon Lee, Hilda H. T. Au, Samuel E. Butcher, Gabriel Cornilescu
Publikováno v:
Proceedings of the National Academy of Sciences. 112
The dicistrovirus intergenic region internal ribosome entry site (IRES) adopts a triple-pseudoknotted RNA structure and occupies the core ribosomal E, P, and A sites to directly recruit the ribosome and initiate translation at a non-AUG codon. A subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81232785da2baf0ce4f3c20bc1c4cb14
https://doi.org/10.1073/pnas.1512088112
https://doi.org/10.1073/pnas.1512088112
Autor:
Preston D. Easterday, Samuel E. Butcher, Andrew L. Lang, Kirk A. Vander Meulen, Kathryn D. Mouzakis
Publikováno v:
Nucleic Acids Research
The human immunodeficiency virus (HIV) requires a programmed −1 ribosomal frameshift for Pol gene expression. The HIV frameshift site consists of a heptanucleotide slippery sequence (UUUUUUA) followed by a spacer region and a downstream RNA stem–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef77e4dfff086919f777d67846a52124
https://pubmed.ncbi.nlm.nih.gov/23248007
https://pubmed.ncbi.nlm.nih.gov/23248007
Autor:
Elizabeth A. Dethoff, Samuel E. Butcher, Kathryn D. Mouzakis, Marco Tonelli, Hashim M. Al-Hashimi
Publikováno v:
Biophysical Journal. (3):644-654
The HIV-1 frameshift site (FS) plays a critical role in viral replication. During translation, the HIV-1 FS transitions from a 3-helix to a 2-helix junction RNA secondary structure. The 2-helix junction structure contains a GGA bulge, and purine-rich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e105ea75224e7b523332ac63a12a0210