Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Kathryn D. Fischer"'
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Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior
Autor: Kathryn D. Fischer, Paul A. Rosenberg, Lori A. Knackstedt
Publikováno v: Neurochem Int
Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide health problems. To date, there are no FDA-approved medications for the treatment of these disorders. Elucidation of the biochemical underpinnings contributing to psychos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6bfac5c72d31904555ff1235da8462
https://pubmed.ncbi.nlm.nih.gov/33159978
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5
Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus
Autor: Chiye Aoki, Laura F. McNair, Paul A. Rosenberg, Blanca I. Aldana, Jens V. Andersen, Helle S. Waagepetersen, Yan Sun, Muzi Du, Kathryn D. Fischer, Jakob D. Nissen, Nathaniel Hodgson
Publikováno v: Neurochemical research. 45(6)
Expression of the glutamate transporter GLT-1 in neurons has been shown to be important for synaptic mitochondrial function in the cerebral cortex. Here we determined whether neuronal GLT-1 plays a similar role in the hippocampus and striatum, using
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7863be70b56d7443742d5cbdec577474
https://pubmed.ncbi.nlm.nih.gov/32144526
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7
Huntington’s disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1
Autor: Paul A. Rosenberg, Kathryn D. Fischer, Geraldine T. Petr, Eileen M. Denovan-Wright, Robert B. Laprairie, Yan Sun
GLT-1 is the major glutamate transporter in the brain, and is expressed in astrocytes and in axon terminals in the hippocampus, cortex, and striatum. Neuronal GLT-1 accounts for only 5–10% of total brain GLT-1 protein, and its function is uncertain
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cf3be61601ae33f414d702425611c3
https://europepmc.org/articles/PMC6249114/
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8
Role of the Major Glutamate Transporter GLT1 in Nucleus Accumbens Core Versus Shell in Cue-Induced Cocaine-Seeking Behavior
Autor: Kathryn D. Fischer, Alexander C.W. Houston, George V. Rebec
Publikováno v: The Journal of Neuroscience. 33:9319-9327
Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc) core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1), which is responsible for >90% of glutamate clearance, occurs in the core of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6966fce78b95bf212264a835dfc011e
https://doi.org/10.1523/jneurosci.3278-12.2013
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9
Differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell
Autor: Kathryn D. Fischer-Smith, George V. Rebec, Alexander C.W. Houston
Publikováno v: Neuroscience. 210:333-339
Cocaine addiction is characterized by compulsive drug seeking, including relapse after a period of withdrawal. The relapse response requires increased glutamate transmission in the nucleus accumbens (NAc). Consistent with this view, glutamate type 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eea4e1235b6d13754a1db9863c743e81
https://doi.org/10.1016/j.neuroscience.2012.02.049
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10
Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes
Autor: Paul A. Rosenberg, Kathryn D. Fischer, Niels C. Danbolt, Clive Miranda, Wencke Armsen, Geraldine T. Petr, Yun Zhou, Natalie M. Frederick, Mustafa Q. Hameed, Edward A. Bedoya, Sameer C. Dhamne, Yan Sun, Alexander Rotenberg, Jianlin Wang, Chiye Aoki
Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(13)
GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a conditional GLT-1 knock-out mouse to uncover cell-type-specific func
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265e5b9915f9b2b05fadcf7187e2dafd
https://pubmed.ncbi.nlm.nih.gov/25834045
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