Výsledky vyhledávání - "Kathryn D. Fischer"

Deletion of Neuronal GLT-1 in Mice Reveals Its Role in Synaptic Glutamate Homeostasis and Mitochondrial Function

Publikováno v: The Journal of Neuroscience. 39:4847-4863

The glutamate transporter GLT-1 is highly expressed in astrocytes but also in neurons, primarily in axon terminals. We generated a conditional neuronal GLT-1 KO using synapsin 1-Cre (synGLT-1 KO) to elucidate the metabolic functions of GLT-1 expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc4bcf9e8e6be537882db97b136d59c9
https://doi.org/10.1523/jneurosci.0894-18.2019

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Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior

Autor: Kathryn D. Fischer, Paul A. Rosenberg, Lori A. Knackstedt

Publikováno v: Neurochem Int

Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide health problems. To date, there are no FDA-approved medications for the treatment of these disorders. Elucidation of the biochemical underpinnings contributing to psychos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6bfac5c72d31904555ff1235da8462
https://pubmed.ncbi.nlm.nih.gov/33159978

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Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine

Autor: Paul A. Rosenberg, Rajeev I. Desai, Alex C W Houston, Rebekah Mannix, Eugene V. Mosharov, Jack Bergman, Kathryn D. Fischer, Nathaniel Hodgson, Michelle R Doyle, David Sulzer, Se Joon Choi, Klaus A. Miczek, Maha Mian, Anita J Bechtholt

Publikováno v: Psychopharmacology. 235:1371-1387

RATIONALE: GLT-1 is the major glutamate transporter in the brain and is expressed predominantly in astrocytes but is also present in excitatory axon terminals. To understand the functional significance of GLT-1 expressed in neurons, we generated a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0868bbbb55d57cc884b0dda98363503b
https://doi.org/10.1007/s00213-018-4848-1

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Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus

Autor: Chiye Aoki, Laura F. McNair, Paul A. Rosenberg, Blanca I. Aldana, Jens V. Andersen, Helle S. Waagepetersen, Yan Sun, Muzi Du, Kathryn D. Fischer, Jakob D. Nissen, Nathaniel Hodgson

Publikováno v: Neurochemical research. 45(6)

Expression of the glutamate transporter GLT-1 in neurons has been shown to be important for synaptic mitochondrial function in the cerebral cortex. Here we determined whether neuronal GLT-1 plays a similar role in the hippocampus and striatum, using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7863be70b56d7443742d5cbdec577474
https://pubmed.ncbi.nlm.nih.gov/32144526

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Huntington’s disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1

Autor: Paul A. Rosenberg, Kathryn D. Fischer, Geraldine T. Petr, Eileen M. Denovan-Wright, Robert B. Laprairie, Yan Sun

GLT-1 is the major glutamate transporter in the brain, and is expressed in astrocytes and in axon terminals in the hippocampus, cortex, and striatum. Neuronal GLT-1 accounts for only 5–10% of total brain GLT-1 protein, and its function is uncertain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cf3be61601ae33f414d702425611c3
https://europepmc.org/articles/PMC6249114/

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Role of the Major Glutamate Transporter GLT1 in Nucleus Accumbens Core Versus Shell in Cue-Induced Cocaine-Seeking Behavior

Autor: Kathryn D. Fischer, Alexander C.W. Houston, George V. Rebec

Publikováno v: The Journal of Neuroscience. 33:9319-9327

Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc) core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1), which is responsible for >90% of glutamate clearance, occurs in the core of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6966fce78b95bf212264a835dfc011e
https://doi.org/10.1523/jneurosci.3278-12.2013

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Differential effects of cocaine access and withdrawal on glutamate type 1 transporter expression in rat nucleus accumbens core and shell

Autor: Kathryn D. Fischer-Smith, George V. Rebec, Alexander C.W. Houston

Publikováno v: Neuroscience. 210:333-339

Cocaine addiction is characterized by compulsive drug seeking, including relapse after a period of withdrawal. The relapse response requires increased glutamate transmission in the nucleus accumbens (NAc). Consistent with this view, glutamate type 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eea4e1235b6d13754a1db9863c743e81
https://doi.org/10.1016/j.neuroscience.2012.02.049

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Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes

Autor: Paul A. Rosenberg, Kathryn D. Fischer, Niels C. Danbolt, Clive Miranda, Wencke Armsen, Geraldine T. Petr, Yun Zhou, Natalie M. Frederick, Mustafa Q. Hameed, Edward A. Bedoya, Sameer C. Dhamne, Yan Sun, Alexander Rotenberg, Jianlin Wang, Chiye Aoki

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(13)

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a conditional GLT-1 knock-out mouse to uncover cell-type-specific func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265e5b9915f9b2b05fadcf7187e2dafd
https://pubmed.ncbi.nlm.nih.gov/25834045

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