Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kathryn B. David"'
Autor:
Robert Pejchal, Rafael S. Depetris, Albert Cupo, William C. Olson, Jeong Hyun Lee, John P. Moore, Rogier W. Sanders, Nicolette Cocco, Jean-Philippe Julien, Milind Kachare, Reza Khayat, Evan Massi, Kathryn B. David, Andre J. Marozsan, Ian A. Wilson, Umesh Katpally, Andrew B. Ward
Publikováno v:
Journal of biological chemistry, 287(29), 24239-24254. American Society for Biochemistry and Molecular Biology Inc.
The trimeric envelope glycoprotein complex (Env) is the focus of vaccine development programs aimed at generating protective humoral responses to human immunodeficiency virus type 1 (HIV-1). N-Linked glycans, which constitute almost half of the molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c36b60c4d278a50a316776d23f52ae
https://doi.org/10.1074/jbc.m112.371898
https://doi.org/10.1074/jbc.m112.371898
Autor:
Dirk Eggink, Mark Melchers, Kathryn B. David, John P. Moore, Ilja Bontjer, Rogier W. Sanders, Ben Berkhout
Publikováno v:
Journal of biological chemistry, 285(47), 36456-36470. American Society for Biochemistry and Molecular Biology Inc.
The envelope glycoproteins (Env) are the focus of HIV-1 vaccine development strategies based on the induction of humoral immunity, but the mechanisms the virus has evolved to limit the induction and binding of neutralizing antibodies (NAbs) constitut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4111beb407a460b1ae51ecc8d8198284
https://doi.org/10.1074/jbc.m110.156588
https://doi.org/10.1074/jbc.m110.156588
Autor:
Mark Melchers, Thijs van Montfort, Ben Berkhout, Ilja Bontjer, Dirk Eggink, Carolien E. van de Sandt, John P. Moore, Katie Matthews, Kathryn B. David, Robert P. de Vries, Rogier W. Sanders
Publikováno v:
Retrovirology, Vol 8, Iss 1, p 48 (2011)
Retrovirology
Retrovirology, 8(1). BioMed Central
Retrovirology
Retrovirology, 8(1). BioMed Central
Background One reason why subunit protein and DNA vaccines are often less immunogenic than live-attenuated and whole-inactivated virus vaccines is that they lack the co-stimulatory signals provided by various components of the more complex vaccines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6ee35fa271191a0cf22ce66ce12f96
https://doi.org/10.1186/1742-4690-8-48
https://doi.org/10.1186/1742-4690-8-48
Autor:
André M. Deelder, Ben Berkhout, William C. Olson, Mark Melchers, Valentin Le Douce, Dirk Eggink, Manfred Wuhrer, Cornelis H. Hokke, John P. Moore, Kathryn B. David, Antu K. Dey, Thijs van Montfort, Benno A. Naaijkens, Kenneth Kang, Rogier W. Sanders
Publikováno v:
Virology, 401(2), 236-247
Virology, 401(2), 236-247. Academic Press Inc.
Virology, 401(2), 236-247. Academic Press Inc.
The HIV-1 envelope glycoprotein complex (Env) is the focus of vaccine development aimed at eliciting humoral immunity. Env's extensive and heterogeneous N-linked glycosylation affects folding, binding to lectin receptors, antigenicity and immunogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e438911f4a21f9f8cf36ad3fca28baab
http://hdl.handle.net/1887/109397
http://hdl.handle.net/1887/109397
Publikováno v:
Virology
Human immunodeficiency virus type 1 (HIV-1) entry into host cells is mediated by the trimeric envelope glycoprotein complex (Env). Accordingly, the Env proteins are the targets for neutralizing antibodies (NAbs) and are the focus of vaccines intended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eab082fe7063d746ea92bc1963a7aa3
https://europepmc.org/articles/PMC3795524/
https://europepmc.org/articles/PMC3795524/
Publikováno v:
Virology. 360(1)
The HIV-1 envelope glycoprotein is expressed on the viral membrane as a trimeric complex, formed by three gp120 surface glycoproteins non-covalently associated with three membrane-anchored gp41 subunits. The labile nature of the association between g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fe9da9965d28de9b560134e5e7634a
https://pubmed.ncbi.nlm.nih.gov/17092531
https://pubmed.ncbi.nlm.nih.gov/17092531
Autor:
Neelanjana Ray, John P. Moore, Thomas J. Ketas, Per Johan Klasse, Kathryn B. David, Robert W. Doms, Antu K. Dey
Publikováno v:
Virology. (1):187-200
The native, functional HIV-1 envelope glycoprotein (Env) complex is a trimer of two non-covalently associated subunits: the gp120 surface glycoprotein and the gp41 transmembrane glycoprotein. However, various non-functional forms of Env are present o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46a566b02f99a2cbe84ae912f3c5596
Autor:
Kathryn B. David, Rogier W. Sanders, Antu K. Dey, Dirk Eggink, John P. Moore, Benno A. Naaijkens, Valentin Le Douce, Kenneth Kang, Mark Melchers, Ben Berkhout, André M. Deelder, Cornelis H. Hokke, Thijs van Montfort, Manfred Wuhrer, William C. Olson
Publikováno v:
Virology. (1):162-163
Corrigendum to “Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function” [Virology 401 (2010) 236–247] Dirk Eggink , Mark Melchers , Manfred Wuhrer , Thijs van Montfort , Antu K. Dey , Benno A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1639caa57c06f324c9f999de64bdcd6c
Autor:
Kathryn B. David, Ilja Bontjer, R. de Vries, John P. Moore, Katie Matthews, Mark Melchers, Rogier W. Sanders, Ben Berkhout, Elizabeth Michael, T. van Montfort, Dirk Eggink
Publikováno v:
Retrovirology, Vol 6, Iss Suppl 3, p P81 (2009)
Retrovirology
Retrovirology
Background Subunit vaccines are often poor immunogens compared to live-attenuated and whole-inactivated virus vaccines. One reason is the lack of costimulatory signals provided by various components of live-attenuated and wholeinactivated vaccines. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228fb9a249b300381a1e2346e0c3614e