CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer

Autor: Kathryn AF Pennel, Jean A Quinn, Colin Nixon, Jitwadee Inthagard, Hester C vanWyk, David Chang, Selma Rebus, GPOL Group, Jennifer Hay, Noori N Maka, Campbell SD Roxburgh, Paul G Horgan, Donald C McMillan, James H Park, Antonia K Roseweir, Colin W Steele, Joanne Edwards

Publikováno v: The Journal of Pathology: Clinical Research, Vol 8, Iss 6, Pp 509-520 (2022)

Abstract CXCL8 is an inflammatory chemokine elevated in the colorectal cancer (CRC) tumour microenvironment. CXCR2, the major receptor for CXCL8, is predominantly expressed by neutrophils. In the cancer setting, CXCL8 plays important roles in neutrop

Externí odkaz: https://doaj.org/article/2587601ff4f442529788ab8eca02bcc0

Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer

Autor: Antonia K. Roseweir, Paul G. Horgan, Prakash Konanahalli, Kathryn Af Pennel, Jitwadee Inthagard, James H. Park, Sara S.F. Al-Badran, Donald C. McMillan, Jean A. Quinn, Joanne Edwards, Campbell S.D. Roxburgh, Liam Hayman, Maejoy B. Campo, Lauren Grant

Publikováno v: The Journal of Pathology: Clinical Research, Vol 7, Iss 2, Pp 121-134 (2021)
The Journal of Pathology: Clinical Research

The tumour microenvironment is an important factor for colorectal cancer prognosis, affecting the patient's immune response. Immune checkpoints, which regulate the immune functions of lymphocytes, may provide prognostic power. This study aimed to inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d654265ce2cabc3b5680e9307692ffb3
https://doaj.org/article/a3ff5f9d8dbd4c0faf511ffc1822eba4

Association of punctate TAK1 expression with mortality in patients with microsatellite-stable colorectal cancer

Autor: Norman James Galbraith, Sara SF Al-Badran, Phimmada Hatthakarnkul, Kathryn AF Pennel, Jean A. Quinn, Lynette Loi, Noori Maka, Colin William Steele, Campbell SD Roxburgh, Donald C. McMillan, Paul G. Horgan, Joanne Edwards

Publikováno v: Journal of Clinical Oncology. 41:220-220

220 Background: Microsatellite stable (MSS) colorectal cancer continues to have limited options for personalised therapeutic targets. The NFKB pathway is known to play an important role in inflammation-related carcinogenesis but has yet to be transla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88cda51fdb1e67d97f712afda063d1c1
https://doi.org/10.1200/jco.2023.41.4_suppl.220

MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

Autor: Anne E. Willis, Laura McDonald, George Skalka, Andrew D. Campbell, Heather McKinnon, Kevin M. Haigis, John R. P. Knight, Sebastian May-Wilson, Kathryn Gilroy, William J. Faller, Emma Stanway, Leah Officer, Rachael C. L. Smith, Joshua D.G. Leach, Joseph A. Waldron, Rachel A. Ridgway, Nicola Valeri, Ewan M. Smith, Arafath Kaja Najumudeen, Nahum Sonenberg, Joanne Edwards, Rene Jackstadt, Ana Teodósio, John Le Quesne, Dustin J. Flanagan, Anne Cheasty, Georgios Kanellos, Kerri McArthur, Christopher G. Proud, Constantinos Alexandrou, Georgios Vlachogiannis, Neil P. Jones, Nikola Vlahov, Owen J. Sansom, Kathryn Af Pennel, Craig MacKay, Martin E. Swarbrick, Martin Bushell

Publikováno v: Knight, J R P, Alexandrou, C, Skalka, G L, Vlahov, N, Pennel, K, Officer, L, Teodosio, A, Kanellos, G, Gay, D M, May-Wilson, S, Smith, E M, Najumudeen, A K, Gilroy, K, Ridgway, R A, Flanagan, D J, Smith, R C L, McDonald, L, MacKay, C, Cheasty, A, McArthur, K, Stanway, E, Leach, J D, Jackstadt, R, Waldron, J A, Campbell, A D, Vlachogiannis, G, Valeri, N, Haigis, K M, Sonenberg, N, Proud, C G, Jones, N P, Swarbrick, M E, McKinnon, H J, Faller, W J, Quesne, J L, Edwards, J, Willis, A E, Bushell, M & Sansom, O J 2021, ' MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression ', Cancer discovery, vol. 11, no. 5, pp. 1228-1247 . https://doi.org/10.1158/2159-8290.CD-20-0652

KRAS-mutant colorectal cancers are resistant to therapeutics, presenting a significant problem for ∼40% of cases. Rapalogs, which inhibit mTORC1 and thus protein synthesis, are significantly less potent in KRAS-mutant colorectal cancer. Using Kras-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b093ca20383c7ab94bac414895dbf3
https://doi.org/10.1158/2159-8290.CD-20-0652

The association between tumour sidedness, clinicopathological characteristics and outcomes in patients undergoing curative resection for colon cancer

Autor: Allan Matthew Golder, Kathryn AF Pennel, David Mansouri, Paul G. Horgan, Campbell SD Roxburgh, Andrew V Biankin, Joanne Edwards, Donald C. McMillan

Publikováno v: Journal of Clinical Oncology. 40:148-148

148 Background: Right-sided colon cancer is associated with worse outcomes than left-sided disease, likely due to an association between tumour/host factors and tumour sidedness. The present study analyses the association between tumour sidedness, cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aff8e224bbab4fe8410f0d437ad937b3
https://doi.org/10.1200/jco.2022.40.4_suppl.148