Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kathryn A. Tunny"'
Autor:
Viral Chikani, Shiro Minami, Michael J. Waters, Ken K. Y. Ho, Jamie Rossjohn, Andrew J. Brooks, Grant A. Ramm, Kathryn A. Tunny, Johan Medina, Robert G. Parton, Mayumi Ishikawa, Manuel A. Fernandez-Rojo, Julian P. Vivian, Yash Chhabra
Publikováno v:
Hepatology (Baltimore, Md.)
Background and Aims Growth hormone (GH) is important for liver regeneration after partial hepatectomy (PHx). We investigated this process in C57BL/6 mice that express different forms of the GH receptor (GHR) with deletions in key signaling domains. A
Autor:
Frederic A. Meunier, Andreas Papadopulos, Michael J. Waters, Yash Chhabra, Birthe B. Kragelund, Ho Yi Wong, Helena Steinocher, Louise F. Nikolajsen, Kathryn A. Tunny, Aaron G. Smith, Andrew J. Brooks
Publikováno v:
Oncogene
Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J & Waters, M J 2018, ' A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation ', Oncogene, vol. 37, pp. 489-501 . https://doi.org/10.1038/onc.2017.352
Chhabra, Y, Wong, H Y, Nikolajsen, L F, Steinocher, H, Papadopulos, A, Tunny, K A, Meunier, F A, Smith, A G, Kragelund, B B, Brooks, A J & Waters, M J 2018, ' A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation ', Oncogene, vol. 37, pp. 489-501 . https://doi.org/10.1038/onc.2017.352
Both humans and mice lacking functional growth hormone (GH) receptors are known to be resistant to cancer. Further, autocrine GH has been reported to act as a cancer promoter. Here we present the first example of a variant of the GH receptor (GHR) as
Autor:
Mark P. Hodson, Brett M. Collins, Weijun Xu, Alexander J. Stevenson, Alun Jones, Gregory M. Kelly, Antje Blumenthal, Wayne A. Johnston, Robert Reid, Shayli Varasteh Moradi, James E. B. Curson, Kathryn A. Tunny, Divya Ramnath, Melanie R. Shakespear, Kirill Alexandrov, Matthew J. Sweet, Jessica B. von Pein, Lin Luo, Ambika M. V. Murthy, Kaustav Das Gupta, David P. Fairlie, Daniel M. Hohenhaus, Abishek Iyer, Jennifer L. Stow, Vikas A. Tillu, Jennifer H. Gunter, Takumi Kobayashi
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2712-2728.e8 (2020)
Summary: Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible aerobic glycolysis and macrophage inflammatory responses. A prote
Autor:
John A. Hamilton, P. Mark Hogarth, Divya Ramnath, Kathryn A. Tunny, Matthew J. Sweet, Glen M. Scholz, Daniel M. Hohenhaus, Ronan Kapetanovic, Claire M Pitts, Anne-Sophie Bergot, Richard A. Sturm
Publikováno v:
Immunology & Cell Biology. 93:771-779
Interferon regulatory factor (IRF) family members impart cell-type specificity to toll-like receptor (TLR) signalling, and we recently identified a role for IRF6 in TLR2 signalling in epithelial cells. TLR3 has a well-characterized role in wound heal
Mechanism of JAK2 Activation by the Archetype Class I Cytokine Receptor, the Growth Hormone Receptor
Autor:
Andrew J. Brooks, Daniel Abankwa, Yash Chhabra, Alan E. Mark, Megan L. O'Mara, Yann Gambin, Wei Dai, Guillermo A. Gomez, Louise F. Nikolajsen, Michael W. Parker, Manolis Doxastakis, Michael J. Waters, Emma Sierecki, Gitte W. Haxholm, Kathryn A. Tunny
Publikováno v:
Biophysical Journal. 110(3)
The growth hormone receptor (GHR) has been the archetype for the class I cytokine receptor family. The original paradigm for how growth hormone (GH) binding to the GHR led to activation of the associated JAK2 was based on biophysical and structural s
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 40:1984-1989
The growth hormone receptor has been an archetype for ligand-induced receptor dimerisation in cytokine receptor signalling. However, we now know that it exists as a constitutive dimer and is activated by a reorganisation of receptor subunits as a res
Autor:
Benjamin M. Hogan, Carol Wicking, Andrew J. Brooks, Huijun Chen, Anne K. Lagendijk, Alisha Tromp, Kathryn A. Tunny, Jessica E. De Angelis, Jeroen Bakkers, Mathias Francois, Kelly A. Smith, Alpha S. Yap, Cas Simons, Neil I. Bower
Publikováno v:
Developmental Cell, 40(2), 123-136. Cell Press
Developmental Cell, 40(2), 123. Cell Press
Developmental Cell, 40(4). Cell Press
Developmental Cell, 40(2), 123. Cell Press
Developmental Cell, 40(4). Cell Press
Angiogenesis is responsible for tissue vascularization during development, as well as in pathological contexts, including cancer and ischemia. Vascular endothelial growth factors (VEGFs) regulate angiogenesis by acting through VEGF receptors to induc
Autor:
Michael J. Waters, Kathryn A. Tunny, Bernard H. Breier, Stewart Gilmour, Peter D. Gluckman, Mark H. Vickers, Arieh Gertler
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 297(3)
Placental human growth hormone-variant (hGH-V) and pituitary human growth hormone-N (hGH-N) are of identical size (22 kDa) but differ in 13 residues scattered throughout the protein. Several isoforms of GH are produced by the hGH-N and hGH-V genes in
Autor:
Manolis Doxastakis, Alan E. Mark, Kathryn A. Tunny, Wei Dai, Guillermo A. Gomez, Michael W. Parker, Kirill Kirill Alexandrov, Megan L. O'Mara, Andrew J. Brooks, Emma Sierecki, Daniel Abankwa, Yann Gambin, Michael J. Waters, Olivier Gardon, Yash Chhabra, Craig J. Morton, Kristopher M. Blucher
Publikováno v:
Cytokine. 70:22
The conformational changes required to transmit the GH binding signal from the extracellular domain of the GH receptor to its intracellular domain resulting in activation of JAK2 has been enigmatic. We have recently defined the first complete mechani
Autor:
Mark H. Vickers, Stewart Gilmour, Michael J. Waters, PD Gluckman, Bernhard H. Breier, Kathryn A. Tunny, Arieh Gertler
Publikováno v:
Growth Hormone & IGF Research. 16:S27