Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kathryn A Wierenga"'
Autor:
Kristen N Gilley, Kathryn A Wierenga, Preeti S Chauhuan, James G Wagner, Ryan P Lewandowski, Elizbeth A Ross, A L Lock, Jack R Harkema, Abby D Benninghoff, James J Pestka
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233183 (2020)
Lupus is a debilitating multi-organ autoimmune disease clinically typified by periods of flare and remission. Exposing lupus-prone female NZBWF1 mice to crystalline silica (cSiO2), a known human autoimmune trigger, mimics flaring by inducing interfer
Externí odkaz:
https://doaj.org/article/c24d4cdb1595420c98ffbc65a67b2209
Autor:
Olivia K. Favor, Lichchavi D. Rajasinghe, Kathryn A. Wierenga, Krishna R. Maddipati, Kin Sing Stephen Lee, Andrew J. Olive, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPhagocytosis of inhaled crystalline silica (cSiO2) particles by tissue-resident alveolar macrophages (AMs) initiates generation of proinflammatory eicosanoids derived from the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid (ARA)
Externí odkaz:
https://doaj.org/article/c5241d8c3bfb4c839104b3a15452ac10
Autor:
Lichchavi D. Rajasinghe, Quan-Zhen Li, Chengsong Zhu, Mei Yan, Preeti S. Chauhan, Kathryn A. Wierenga, Melissa A. Bates, Jack R. Harkema, Abby D. Benninghoff, James J. Pestka
Publikováno v:
Autoimmunity, Vol 53, Iss 7, Pp 415-433 (2020)
Inhalation of crystalline silica (cSiO2) in the workplace is etiologically linked to lupus and other autoimmune diseases. Exposing lupus-prone NZBWF1 mice to respirable cSiO2 unleashes a vicious cycle of inflammation and cell death in the lung that t
Externí odkaz:
https://doaj.org/article/88c45cb13ba94771ace3f1fe7e918ae4
Autor:
Lichchavi D. Rajasinghe, Preeti S. Chauhan, Kathryn A. Wierenga, Augustus O. Evered, Shamya N. Harris, Melissa A. Bates, Mikhail A. Gavrilin, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Airway exposure of lupus-prone NZBWF1 mice to crystalline silica (cSiO2), a known trigger of human autoimmune disease, elicits sterile inflammation and alveolar macrophage death in the lung that, in turn, induces early autoimmune onset and accelerate
Externí odkaz:
https://doaj.org/article/9c26a1a9e0164d58ae9d392d53d2f12c
Autor:
Kathryn A. Wierenga, Rita S. Strakovsky, Abby D. Benninghoff, Lichchavi D. Rajasinghe, Adam L. Lock, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Lupus is a systemic autoimmune disease typified by uncontrolled inflammation, disruption of immune tolerance, and intermittent flaring – events triggerable by environmental factors. Preclinical and clinical studies reveal that consumption of the ma
Externí odkaz:
https://doaj.org/article/017f16990df246459ca40f252e6debe8
Autor:
Abby D. Benninghoff, Melissa A. Bates, Preeti S. Chauhan, Kathryn A. Wierenga, Kristen N. Gilley, Andrij Holian, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Exposure of lupus-prone female NZBWF1 mice to respirable crystalline silica (cSiO2), a known human autoimmune trigger, initiates loss of tolerance, rapid progression of autoimmunity, and early onset of glomerulonephritis. We have previously demonstra
Externí odkaz:
https://doaj.org/article/6a7cc55cbb8244a38e205d980fe5ec6a
Autor:
Kathryn A. Wierenga, Josephine Wee, Kristen N. Gilley, Lichchavi D. Rajasinghe, Melissa A. Bates, Mikhail A. Gavrilin, Andrij Holian, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Occupational exposure to respirable crystalline silica (cSiO2) has been etiologically linked to human autoimmunity. Intranasal instillation with cSiO2 triggers profuse inflammation in the lung and onset of autoimmunity in lupus-prone mice; however, d
Externí odkaz:
https://doaj.org/article/1943c79994934e2fac188c8732bd0b4b
Publikováno v:
ImmunoHorizons. 6:156-169
Alveolar macrophages (AMs) are tissue-resident cells in the lungs derived from the fetal liver that maintain lung homeostasis and respond to inhaled stimuli. Although the importance of AMs is undisputed, they remain refractory to standard experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaa171859a6b4b67ff6b067e51ba75d1
https://doi.org/10.4049/immunohorizons.2200011
https://doi.org/10.4049/immunohorizons.2200011
Autor:
Melissa A. Bates, Peyman Akbari, Kristen N. Gilley, James G. Wagner, Ning Li, Anna K. Kopec, Kathryn A. Wierenga, Daven Jackson-Humbles, Christina Brandenberger, Andrij Holian, Abby D. Benninghoff, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Ectopic lymphoid structures (ELS) consist of B-cell and T-cell aggregates that are initiated de novo in inflamed tissues outside of secondary lymphoid organs. When organized within follicular dendritic cell (FDC) networks, ELS contain functional germ
Externí odkaz:
https://doaj.org/article/b4642ab0353c4492b537d870d8e55c4f
Autor:
Lichchavi D. Rajasinghe, Melissa A. Bates, Abby D. Benninghoff, Kathryn A. Wierenga, Jack R. Harkema, James J. Pestka
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Frontiers in Immunology
Frontiers in Immunology
Repeated short-term intranasal instillation of lupus-prone mice with crystalline silica (cSiO2) induces inflammatory gene expression and ectopic lymphoid neogenesis in the lung, leading to early onset of systemic autoimmunity and rapid progression to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd05c9ca258c2979c3e425a4d209adc
https://doi.org/10.3389/fimmu.2021.781446
https://doi.org/10.3389/fimmu.2021.781446