Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kathryn, Wolhuter"'
Autor:
Raphael F. Queiroz, Christopher P. Stanley, Kathryn Wolhuter, Stephanie M. Y. Kong, Ragul Rajivan, Naomi McKinnon, Giang T. H. Nguyen, Antonella Roveri, Sebastian Guttzeit, Philip Eaton, William A. Donald, Fulvio Ursini, Christine C. Winterbourn, Anita Ayer, Roland Stocker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
A major question in redox signaling is how H2O2 oxidizes target protein thiols in the presence of glutathione peroxidases and peroxiredoxins. We reveal signaling by H2O2 via its enzymatic conversion to an alkyl hydroperoxide that stereo-specifically
Externí odkaz:
https://doaj.org/article/16b1acb3e2684793a89d03d6d3dc92b4
Autor:
Lijiang Ma, Nicole S Bryce, Adam W Turner, Antonio F Di Narzo, Karishma Rahman, Yang Xu, Raili Ermel, Katyayani Sukhavasi, Valentina d'Escamard, Nirupama Chandel, Bhargavi V'Gangula, Kathryn Wolhuter, Daniella Kadian-Dodov, Oscar Franzen, Arno Ruusalepp, Ke Hao, Clint L Miller, Johan L M Björkegren, Jason C Kovacic
Publikováno v:
PLoS Genetics, Vol 18, Iss 6, p e1010261 (2022)
Genome wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of common disorders. However, since the large majority of these risk SNPs reside outside gene-coding regions, GWAS gen
Externí odkaz:
https://doaj.org/article/8f50972152a349d08f4369b9b5980542
Publikováno v:
Antioxidants & Redox Signaling. 38:1022-1040
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc525ca07d6491fe4cb8475ec10936f
https://doi.org/10.1089/ars.2022.0204
https://doi.org/10.1089/ars.2022.0204
Autor:
Anita Ayer, Giang T H Nguyen, Christopher P. Stanley, Naomi McKinnon, Ragul Rajivan, Roland Stocker, Antonella Roveri, Sebastian Guttzeit, William A. Donald, Kathryn Wolhuter, Philip Eaton, Raphael F Queiroz, Fulvio Ursini, Christine C. Winterbourn, Stephanie M Y Kong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
During systemic inflammation, indoleamine 2,3-dioxygenase 1 (IDO1) becomes expressed in endothelial cells where it uses hydrogen peroxide (H2O2) to oxidize L-tryptophan to the tricyclic hydroperoxide, cis-WOOH, that then relaxes arteries via oxidatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcdda4e1336420a954edd905fcd5ccd
https://doaj.org/article/16b1acb3e2684793a89d03d6d3dc92b4
https://doaj.org/article/16b1acb3e2684793a89d03d6d3dc92b4
Autor:
Ke Hao, Raili Ermel, Katyayani Sukhavasi, Haoxiang Cheng, Lijiang Ma, Ling Li, Letizia Amadori, Simon Koplev, Oscar Franzén, Valentina d’Escamard, Nirupama Chandel, Kathryn Wolhuter, Nicole S. Bryce, Vamsidhar R.M. Venkata, Clint L. Miller, Arno Ruusalepp, Heribert Schunkert, Johan L.M. Björkegren, Jason C. Kovacic
Publikováno v:
Circ Genom Precis Med
Background: Hundreds of candidate genes have been associated with coronary artery disease (CAD) through genome-wide association studies. However, a systematic way to understand the causal mechanism(s) of these genes, and a means to prioritize them fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fa346728c1c64736287de11f8b0eec
https://doi.org/10.1161/circgen.121.003365
https://doi.org/10.1161/circgen.121.003365
Autor:
Oleksandra, Prysyazhna, Kathryn, Wolhuter, Christopher, Switzer, Celio, Santos, Xiaoping, Yang, Steven, Lynham, Ajay M, Shah, Philip, Eaton, Joseph R, Burgoyne
Publikováno v:
Circulation
Prysyazhna, O, Wolhuter, K, Switzer, C H, Santos, C, Yang, X, Lynham, S, Shah, A M, Eaton, P & Burgoyne, J 2019, ' Blood pressure-lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase ', Circulation, vol. 140, no. 2, pp. 126–137 . https://doi.org/10.1161/CIRCULATIONAHA.118.037398
Prysyazhna, O, Wolhuter, K, Switzer, C H, Santos, C, Yang, X, Lynham, S, Shah, A M, Eaton, P & Burgoyne, J 2019, ' Blood pressure-lowering by the antioxidant resveratrol is counterintuitively mediated by oxidation of cGMP-dependent protein kinase ', Circulation, vol. 140, no. 2, pp. 126–137 . https://doi.org/10.1161/CIRCULATIONAHA.118.037398
Supplemental Digital Content is available in the text.
Background: The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the mechanisms of its therapeutic acti
Background: The health-promoting and disease-limiting abilities of resveratrol, a natural polyphenol, has led to considerable interest in understanding the mechanisms of its therapeutic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::822b5cae90c65dc55eb80b7a3dd491d6
http://europepmc.org/articles/PMC6635045
http://europepmc.org/articles/PMC6635045
Publikováno v:
Bioessays
Air pollution is a major global challenge for a multitude of reasons. As a specific concern, there is now compelling evidence demonstrating a causal relationship between exposure to airborne pollutants and the onset of cardiovascular disease (CVD). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef398ce5752b5f19d39bcda1c59b9075
http://europepmc.org/articles/PMC8209912
http://europepmc.org/articles/PMC8209912
Autor:
Oleksandra Prysyazhna, Joseph R. Burgoyne, Christopher H. Switzer, Steven Lynham, Xiaoping Yang, Ajay M. Shah, Kathryn Wolhuter, Celio X.C. Santos, Philip Eaton
Publikováno v:
Circulation. 140(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08130e75eddf7193f738a781b1936bd
https://pubmed.ncbi.nlm.nih.gov/31765253
https://pubmed.ncbi.nlm.nih.gov/31765253
Autor:
Sudhir Shengule, Anita Ayer, Philip Eaton, Christopher P. Stanley, Oleksandra Prysyazhna, Kathryn Wolhuter, Louise L. Dunn, Yorihiro Yamamoto, Ghassan J. Maghzal, Cacang Suarna, Richard J. Payne, Jihan Talib, Preet S. Chadha, Jenna Scotcher, Paolo Di Mascio, Yutang Wang, Roland Stocker, Nghi H. Nguyen, Andrew M. Giltrap, Jonathan B. Baell, Jephthah O. Odiba, Johannes-Peter Stasch, Fernanda M. Prado
Publikováno v:
Stanley, C P, Maghzal, G J, Ayer, A, Talib, J, Giltrap, A M, Shengule, S, Wolhuter, K, Wang, Y, Chadha, P, Suarna, C, Prysyazhna, O, Scotcher, J, Dunn, L L, Prado, F M, Nguyen, N, Odiba, J O, Baell, J B, Stasch, J P, Yamamoto, Y, Di Mascio, P, Eaton, P, Payne, R J & Stocker, R 2019, ' Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation ', Nature, vol. 566, no. 7745, pp. 548-552 . https://doi.org/10.1038/s41586-019-0947-3
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Singlet molecular oxygen ( 1 O 2 ) has well-established roles in photosynthetic plants, bacteria and fungi 1–3 , but not in mammals. Chemically generated 1 O 2 oxidizes the amino acid tryptophan to precursors of a key metabolite called N-formylkynu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e9b33be3bb7ffa4340248ba2f051f8
https://pubmed.ncbi.nlm.nih.gov/30809049
https://pubmed.ncbi.nlm.nih.gov/30809049
Autor:
Philip Eaton, Kathryn Wolhuter
Publikováno v:
Wolhuter, K & Eaton, P 2017, ' How widespread is stable protein S-nitrosylation as an end-effector of protein regulation? ', Free Radical Biology and Medicine . https://doi.org/10.1016/j.freeradbiomed.2017.02.013
Over the last 25 years protein S-nitrosylation, also known more correctly as S-nitrosation, has been progressively implicated in virtually every nitric oxide-regulated process within the cardiovascular system. The current, widely-held paradigm is tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514d3cd1c1ee630bc59300a9d481a9d2
https://kclpure.kcl.ac.uk/en/publications/73984081-a906-4939-af4a-3667730d9761
https://kclpure.kcl.ac.uk/en/publications/73984081-a906-4939-af4a-3667730d9761
