Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Kathryn, Crouch"'
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-18 (2023)
Abstract Background Eukaryotes such as fungi and protists frequently accompany bacteria and archaea in microbial communities. Unfortunately, their presence is difficult to study with “shotgun” metagenomic sequencing since prokaryotic signals domi
Externí odkaz:
https://doaj.org/article/cb35a02735874a11a76deb3e5a7bf3b0
Autor:
Achchuthan Shanmugasundram, David Starns, Ulrike Böhme, Beatrice Amos, Paul A Wilkinson, Omar S Harb, Susanne Warrenfeltz, Jessica C Kissinger, Mary Ann McDowell, David S Roos, Kathryn Crouch, Andrew R Jones
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011058 (2023)
Parasitic diseases caused by kinetoplastid parasites are a burden to public health throughout tropical and subtropical regions of the world. TriTrypDB (https://tritrypdb.org) is a free online resource for data mining of genomic and functional data fr
Externí odkaz:
https://doaj.org/article/376d108ca2a94805950a5651f8c3e5c9
Autor:
Stevie A Bain, Heleen Plaisier, Felicity Anderson, Nicola Cook, Kathryn Crouch, Thomas R Meagher, Michael G Ritchie, Edward W J Wallace, Daniel Barker
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009705 (2022)
Over the last few decades, the nature of life sciences research has changed enormously, generating a need for a workforce with a variety of computational skills such as those required to store, manage, and analyse the large biological datasets produc
Externí odkaz:
https://doaj.org/article/798334d895124c8d80698c322e2a40b7
Autor:
Pieter C Steketee, Federica Giordani, Isabel M Vincent, Kathryn Crouch, Fiona Achcar, Nicholas J Dickens, Liam J Morrison, Annette MacLeod, Michael P Barrett
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the
Externí odkaz:
https://doaj.org/article/005c928361f64560b5b954accbc88a07
Autor:
Pieter C Steketee, Emily A Dickie, James Iremonger, Kathryn Crouch, Edith Paxton, Siddharth Jayaraman, Omar A Alfituri, Georgina Awuah-Mensah, Ryan Ritchie, Achim Schnaufer, Tim Rowan, Harry P de Koning, Catarina Gadelha, Bill Wickstead, Michael P Barrett, Liam J Morrison
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009734 (2021)
Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit
Externí odkaz:
https://doaj.org/article/d876db67785745d3836a0959a9e3e077
Autor:
Jeziel Dener Damasceno, Catarina A Marques, Dario Beraldi, Kathryn Crouch, Craig Lapsley, Ricardo Obonaga, Luiz RO Tosi, Richard McCulloch
Publikováno v:
eLife, Vol 9 (2020)
DNA replication is needed to duplicate a cell’s genome in S phase and segregate it during cell division. Previous work in Leishmania detected DNA replication initiation at just a single region in each chromosome, an organisation predicted to be ins
Externí odkaz:
https://doaj.org/article/4001a244fbe04e1ca359036aba6df1ad
Autor:
Jeziel D Damasceno, João Reis-Cunha, Kathryn Crouch, Dario Beraldi, Craig Lapsley, Luiz R O Tosi, Daniella Bartholomeu, Richard McCulloch
Publikováno v:
PLoS Genetics, Vol 16, Iss 7, p e1008828 (2020)
Homologous recombination (HR) has an intimate relationship with genome replication, both during repair of DNA lesions that might prevent DNA synthesis and in tackling stalls to the replication fork. Recent studies led us to ask if HR might have a mor
Externí odkaz:
https://doaj.org/article/5b83c8d4ddcf4ebf9a2bea64dcca3889
Autor:
Jennifer Ann Black, Kathryn Crouch, Leandro Lemgruber, Craig Lapsley, Nicholas Dickens, Luiz R.O. Tosi, Jeremy C. Mottram, Richard McCulloch
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 836-851.e5 (2020)
Summary: Trypanosoma brucei evades mammalian immunity by using recombination to switch its surface-expressed variant surface glycoprotein (VSG), while ensuring that only one of many subtelomeric multigene VSG expression sites are transcribed at a tim
Externí odkaz:
https://doaj.org/article/e8ce131731db410ba63d97f8d0b4fded
Autor:
Juliana B.T. Carnielli, Kathryn Crouch, Sarah Forrester, Vladimir Costa Silva, Sílvio F.G. Carvalho, Jeziel D. Damasceno, Elaine Brown, Nicholas J. Dickens, Dorcas L. Costa, Carlos H.N. Costa, Reynaldo Dietze, Daniel C. Jeffares, Jeremy C. Mottram
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 83-91 (2018)
Background: Miltefosine has been used successfully to treat visceral leishmaniasis (VL) in India, but it was unsuccessful for VL in a clinical trial in Brazil. Methods: To identify molecular markers that predict VL treatment failure whole genome sequ
Externí odkaz:
https://doaj.org/article/145ad3033b9640be9b25964b8bb852ab
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007729 (2018)
Switching of the Variant Surface Glycoprotein (VSG) in Trypanosoma brucei provides a crucial host immune evasion strategy that is catalysed both by transcription and recombination reactions, each operating within specialised telomeric VSG expression
Externí odkaz:
https://doaj.org/article/1f0645da46734f4fafaf0802bcbb1916