Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kathrina L. Marcelo"'
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Pp 121-127 (2020)
A major breakthrough in cancer treatment was ushered in by the development of immune checkpoint blockade therapy such as anti-CTLA4 antibody and anti-PD-1 and anti-programmed cell death-ligand 1 antibodies that are now approved for use in an increasi
Externí odkaz:
https://doaj.org/article/f841a1c624b247069822f5d967960744
Autor:
Niamh Coleman, Kathrina L. Marcelo, Julia F. Hopkins, Nusrat Israr Khan, Robyn Du, Lingzhi Hong, Edward Park, Binaifer Balsara, Mollie Leoni, Curtis Pickering, Jeffrey Myers, John Heymach, Lee A. Albacker, David Hong, Maura Gillison, Xiuning Le
Publikováno v:
JCO Precision Oncology.
PURPOSE In head and neck squamous cell carcinoma (HNSCC), HRAS mutation is a new actionable oncogene driver. We aimed to evaluate HRAS mutational variants, comutation profile, and survival outcomes of this molecularly defined population. METHODS We l
Autor:
Xiuning Le, Minghao Dang, Venkatesh L. Hegde, Bo Jiang, Ravaen Slay, Weihong Xiao, Keiko Akagi, Joseph Fresquez, Kathrina L. Marcelo, Qianyun Luo, Pragya Sinha, Ananta V. Yanamandra, Joe Dan Dunn, Diana Bell, Michelle Williams, Edwin Parra, Ryan Goepfert, Stephen H. Lai, Neil Gross, Amit Agrawal, Alexandre Reuben, Jeffrey Myers, Michael A. Curran, K. Jagannadha Sastry, Linghua Wang, Maura L. Gillison
The authors have withdrawn their manuscript because a major revision is in progress to incorporate additional data. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef65d3876e88b562fd9139ddc404a426
https://doi.org/10.1101/2021.12.02.21266776
https://doi.org/10.1101/2021.12.02.21266776
Autor:
Sean Khozin, Johnique T. Atkins, Patricia LoRusso, David S. Hong, Goldy C. George, Gautam Borthakur, Kathrina L. Marcelo-Lewis, Ying Yuan, Kenneth R. Hess
Publikováno v:
British Journal of Cancer
Background Our objective was to determine the correlation between preclinical toxicity found in animal models (mouse, rat, dog and monkey) and clinical toxicity reported in patients participating in Phase 1 oncology clinical trials. Methods We obtain
Publikováno v:
Phase I Oncology Drug Development ISBN: 9783030476816
Over 1100 cancer drugs are in development representing an increase in effort and progress in cancer drug discovery. The starting point of clinical development is Phase 1 clinical trials and the need for dedicated Phase I units have emerged as forefro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b4e343883efd165d6f0733dfdc826ea
https://doi.org/10.1007/978-3-030-47682-3_4
https://doi.org/10.1007/978-3-030-47682-3_4
Autor:
Kathrina L. Marcelo, Suman Maity, Jianqiang Mao, Nagireddy Putluri, Fumin Lin, Feng Li, Adam Dean, Naomi Gonzales, David M. Gooden, Brian York, Anthony R. Means, Cristian Coarfa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Binding of calcium to its intracellular receptor calmodulin (CaM) activates a family of Ca2+/CaM-dependent protein kinases. CaMKK2 (Ca2+/CaM-dependent protein kinase kinase 2) is a central member of this kinase family as it controls the actions of a
Autor:
Christopher B. Newgard, Anna Tsimelzon, Susan G. Hilsenbeck, Robert Stevens, Olga Ilkayeva, James R. Bain, Anthony R. Means, Thomas J. Ribar, Brian York, Christopher R. Means, Kathrina L. Marcelo
Publikováno v:
Molecular Endocrinology. 30:557-572
A number of epidemiological studies have implicated calcium (Ca(2+)) signaling as a major factor in obesity that contributes to aberrant systems metabolism. Somewhat paradoxically, obesity correlates with decreased circulating Ca(2+) levels, leading
Autor:
Cristian Coarfa, Fumin Lin, Kimal Rajapakshe, Holly Robinson, Anthony R. Means, Lauren C. Goldie, Eva M. Sevick, Adam Dean, Kathrina L. Marcelo, Karl-Dimiter Bissig, Brian York, Nathaniel Wilganowski
Publikováno v:
Hepatology. 62:505-520
Hepatic cancer is one of the most lethal cancers worldwide. Here, we report that the expression of Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is significantly up-regulated in hepatocellular carcinoma (HCC) and negatively correlated wi
Autor:
Kathrina L. Marcelo, Erin Stashi, Kimal Rajapakshe, Loning Fu, Bokai Zhu, Blythe Gorman, Tiffany Fleet, Bert W. O'Malley, Brian York, Nicole M. Kettner, Cristian Coarfa
Circadian rhythmicity is a fundamental process that synchronizes behavioral cues with metabolic homeostasis. Disruption of daily cycles due to jet lag or shift work results in severe physiological consequences including advanced aging, metabolic synd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8f0f1abac602abcf50270026e29d21
https://europepmc.org/articles/PMC5248931/
https://europepmc.org/articles/PMC5248931/
Publikováno v:
Journal of Visualized Experiments : JoVE
The specification of hemogenic endothelial cells from embryonic vascular endothelium occurs during brief developmental periods within distinct tissues, and is necessary for the emergence of definitive HSPC from the murine extra embryonic yolk sac, pl