The Multicomponent Medicinal Product Hepar Compositum Reduces Hepatic Inflammation and Fibrosis in a Streptozotocin- and High-Fat Diet-Induced Model of Metabolic Dysfunction-Associated Steatotic Liver Disease/Metabolic Dysfunction-Associated Steatohepatitis

Autor: Yvonne Burmeister, Kathrin Weyer, Achim Dörre, Bernd Seilheimer

Publikováno v: Biomedicines, Vol 11, Iss 12, p 3216 (2023)

Metabolic dysfunction-associated steatotic liver disease (MASLD)—formerly known as non-alcoholic fatty liver disease (NAFLD)—is the most common chronic liver disease worldwide. Since there is currently no approved pharmacotherapy for MASLD, there

Externí odkaz: https://doaj.org/article/a4e56f1d3a234288a5f46ccba90895bb

The extrafollicular response is sufficient to drive initiation of autoimmunity and early disease hallmarks of lupus

Autor: Lasse F. Voss, Amanda J. Howarth, Thomas R. Wittenborn, Sandra Hummelgaard, Kristian Juul-Madsen, Kristian S. Kastberg, Mathias K. Pedersen, Lisbeth Jensen, Anastasios D. Papanastasiou, Thomas Vorup-Jensen, Kathrin Weyer, Søren E. Degn

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionMany autoimmune diseases are characterized by germinal center (GC)-derived, affinity-matured, class-switched autoantibodies, and strategies to block GC formation and progression are currently being explored clinically. However, extrafolli

Externí odkaz: https://doaj.org/article/46d5f2474f894fdb93f2952297ceffaf

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

Autor: Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. Pharmacological i

Externí odkaz: https://doaj.org/article/e6df4a8d335842ca8793c25354c164bc

Megalin-Mediated Endocytosis in the Kidney Proximal Tubule: Relevance to Regulation of the Renal Renin-Angiotensin System

Autor: Kathrin Weyer, Sandra Hummelgaard

Publikováno v: Hummelgaard, S & Weyer, K 2023, ' Megalin-Mediated Endocytosis in the Kidney Proximal Tubule : Relevance to Regulation of the Renal Renin-Angiotensin System ', Nephron, vol. 147, no. 3-4, pp. 244–249 . https://doi.org/10.1159/000526369

The kidney proximal tubule is a major target tissue of the renin-angiotensin system (RAS). Megalin is an endocytic multiligand receptor abundantly expressed in the proximal tubule where it drives reabsorption of peptides and proteins from the glomeru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffffea820a3ea8fd1b3c6f1f2b2dcdb
https://doi.org/10.1159/000526369

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

Autor: Simon Glerup, Yu Yamazaki, Melissa E. Murray, Yuka A. Martens, Marie Louise Holm, Takahisa Kanekiyo, Dennis W. Dickson, Mitsuru Shinohara, Kathrin Weyer, Patrick Sullivan, Masaya Tachibana, Tomonori Aikawa, Guojun Bu, Chia Chen Liu, Hiroshi Oue

Publikováno v: Tachibana, M, Holm, M-L, Liu, C-C, Shinohara, M, Aikawa, T, Oue, H, Yamazaki, Y, Martens, Y A, Murray, M E, Sullivan, P M, Weyer, K, Glerup, S, Dickson, D W, Bu, G & Kanekiyo, T 2019, ' APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1 ', Journal of Clinical Investigation, vol. 129, no. 3, pp. 1272-1277 . https://doi.org/10.1172/JCI124853

Carrying the ε4 allele of the APOE gene encoding apolipoprotein E (APOE4) markedly increases the risk for late-onset Alzheimer's disease (AD), in which APOE4 exacerbates the brain accumulation and subsequent deposition of amyloid-β (Aβ) peptides.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aca59f9df01c440c5ee696c3fdfb7a6
https://doi.org/10.1172/jci124853