Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kathrin T. Doepfner"'
Autor:
Alexandre Arcaro, Michael A. Grotzer, Angelika Eggert, André O. von Bueren, Tarek Shalaby, Kathrin T. Doepfner, Alexander Schramm, Danielle Boller
Purpose: The phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in human cancer and plays a crucial role in neuroblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K/Akt signaling as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac2f9ff324535073242c6d2cffd8558
https://doi.org/10.1158/1078-0432.c.6517042.v1
https://doi.org/10.1158/1078-0432.c.6517042.v1
Autor:
Alexandre Arcaro, Michael A. Grotzer, Angelika Eggert, André O. von Bueren, Tarek Shalaby, Kathrin T. Doepfner, Alexander Schramm, Danielle Boller
Supplementary Figures S1-S2 from Targeting the Phosphoinositide 3-Kinase Isoform p110δ Impairs Growth and Survival in Neuroblastoma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1f567caf1a5c642f9915cbe257437a
https://doi.org/10.1158/1078-0432.22439602.v1
https://doi.org/10.1158/1078-0432.22439602.v1
Autor:
André O. von Bueren, Tarek Shalaby, Danielle Boller, Angelika Eggert, Alexandre Arcaro, Alexander Schramm, Kathrin T. Doepfner, Michael A. Grotzer
Publikováno v:
Clinical Cancer Research. 14:1172-1181
Purpose: The phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in human cancer and plays a crucial role in neuroblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K/Akt signaling as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1690b513732630c12e6fa65e823e7f
https://doi.org/10.1158/1078-0432.ccr-07-0737
https://doi.org/10.1158/1078-0432.ccr-07-0737
Publikováno v:
Critical Reviews in Oncology/Hematology. 63:215-230
Acute myeloid leukemia (AML) is a quickly progressing, heterogeneous clonal disorder of hematopoietic progenitor cells. Significant progress in understanding the pathogenesis of AML has been achieved in the past few years. Two major types of genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df980858a5471007d0e8acac96b2d2e
https://doi.org/10.1016/j.critrevonc.2007.05.005
https://doi.org/10.1016/j.critrevonc.2007.05.005
Autor:
Barbara M. Fischer, Kathrin T. Doepfner, Olivier Delattre, Tarek Shalaby, Shaun P. Jackson, Danielle Boller, Ana S Guerreiro, Simone M. Schoenwaelder, Alexandre Arcaro, Michael A. Grotzer
Publikováno v:
Biochemical Journal. 406:57-66
AT/RTs (atypical teratoid/rhabdoid tumours) of the CNS (central nervous system) are childhood malignancies associated with poor survival rates due to resistance to conventional treatments such as chemotherapy. We characterized a panel of human AT/RT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbc7ae3322b71d151b15f563f24573d
https://doi.org/10.1042/bj20070309
https://doi.org/10.1042/bj20070309
Publikováno v:
Leukemia. 21:1921-1930
Insulin-like growth factor (IGF) signaling plays an important role in various human cancers. Therefore, the role of insulin-like growth factor I (IGF-I) signaling in growth and survival of acute myeloid leukemia (AML) cells was investigated. Expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97d280808f631e5f3d5d02a53f44c0b
https://doi.org/10.1038/sj.leu.2404813
https://doi.org/10.1038/sj.leu.2404813
Autor:
Kathrin T. Doepfner, Danielle Boller, Marin Marinov, Angela De Laurentiis, Ana S Guerreiro, Alexandre Arcaro
Publikováno v:
Scopus-Elsevier
Phosphoinositide 3-kinases (PI3Ks) play an essential role in the signal transduction events initiated by the binding of extracellular signals to their cell surface receptors. There are eight known PI3Ks in humans, which have been subdivided into thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d46edc72088ad683a26613049fd685
https://pubmed.ncbi.nlm.nih.gov/19075915
https://pubmed.ncbi.nlm.nih.gov/19075915
Publikováno v:
Current Biology. 15(13)
The control of cellular growth is tightly linked to the regulation of protein synthesis. A key function in translation initiation is fulfilled by the 5′ cap binding eukaryotic initiation factor 4E (eIF4E), and dysregulation of eIF4E is associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89d80b39a7b5ea5fc67dc8d0c864c0c